A5010282039- Dementia and Cognitive Impairment Research
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Neurobiology of Language and Bilingualism
- Meningioma and schwannoma management
- Alzheimer's disease research and treatments
- Cancer-related cognitive impairment studies
- CAR-T cell therapy research
- Ophthalmology and Eye Disorders
- Natural product bioactivities and synthesis
- Neuroscience and Music Perception
- Pituitary Gland Disorders and Treatments
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Multiple Sclerosis Research Studies
- Cancer Immunotherapy and Biomarkers
- Health disparities and outcomes
- Hormonal Regulation and Hypertension
- Migraine and Headache Studies
- Health, Medicine and Society
- Stroke Rehabilitation and Recovery
- Nanowire Synthesis and Applications
- Ginseng Biological Effects and Applications
- Radiopharmaceutical Chemistry and Applications
Hôpital Saint-Louis
2018-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris Cité
2000-2023
Université de Lille
2022
Hôpital Fernand-Widal
2021-2022
Université de Strasbourg
2022
Cognitive Neuroimaging Lab
2022
Hôpital Avicenne
2010-2021
Centre National de la Recherche Scientifique
2000-2021
Université Paris-Saclay
2021
Abstract Chimeric antigen receptor-modified T (CAR T) cell therapy is a highly promising treatment for haematological malignancies but frequently associated with cytokine release syndrome and neurotoxicity. Between July 2018 2019, all patients treated CD19-targeted CAR T-cell relapsing lymphoma were followed-up longitudinally to describe neurological symptoms their evolution over time. Four different French centres participated 84 (median age 59 years, 31% females) included. Neurotoxicity,...
Approximately 10% of patients with non-small cell lung cancer (NSCLC) have brain metastases at the time diagnosis. When surgical resection is not possible, whole radiotherapy standard care, a cerebral response rate approximately 30%. We report our experience an upfront association carboplatin and pemetrexed (areas under curve, 5 500 mg/m2, respectively), every 3 weeks, in 30 presenting newly diagnosed NSCLC. Cerebral MRIs were performed 6–9 weeks. The radiologic rates assessed according to...
Isolated subjective cognitive impairment (SCI) and mild (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study patients SCI MCI clinic, neuropsychology, biology, brain imaging data. We aimed to compare symptoms DLB others in this at baseline.Participants French cohort were recruited for either or MCI. Among them, 892 included sub-study, designed search specifically DLB. Probable diagnosis (pro-DLB group) was done using two-criteria cutoff score among...
PURPOSE: To document the changes observed at sequential magnetic resonance (MR) imaging of sarcoidosis lesions central nervous system (CNS) during treatment with corticosteroids. MATERIALS AND METHODS: The abnormalities detected in 24 patients (mean follow-up, 36 months) were compared before and after therapeutic periods (n = 75) that divided into attack (high-dose), upkeep (decreased-dose), minimal (low-dose) periods. Parenchymal classified as type 1 (enhanced gadolinium), 2...
Although previous studies suggest that music may facilitate verbal learning in a healthy population, such mnemonic effect has seldom been investigated Alzheimer's disease (AD). Moreover, memorization of texts was generally compared when either sung or spoken. In the present study, it examined whether benefit observed on specific to an associative context binding items together led similar benefits, regardless nature association.Twelve patients with mild AD and 15 controls learned presented...
The natural history and disease mechanisms of Alzheimer's related disorders (ADRD) are still poorly understood. Very few resources available to scrutinise patients as early needed use integrative approaches combining standardised, repeated clinical investigations cutting-edge biomarker measurements.In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics screened for either isolated subjective cognitive complaints (SCCs) or mild impairment (MCI; defined...
Objective To assess progression of semantic loss in early stages cognitive decline using and letter fluency performance, its relation with Alzheimer's disease (AD)-specific neurodegeneration longitudinal multimodal neuroimaging measures. Methods Change verbal was analyzed among 2261 non-demented individuals a follow-up diagnosis no mild impairment (MCI), amnestic MCI (aMCI), non-amnestic (naMCI), or incident dementia, linear mixed models across 4 years follow-up, relations magnetic resonance...
Chimeric antigen receptor-modified T (CAR T) cells are profoundly changing the standard of care in B-cell malignancies. This new therapeutic class induces a significant number acute neurotoxicity, but data regarding mid- and long-term neurological safety scarce. We evaluated mid-term safety, with special emphasis on cognitive functions, series adults treated CAR cells.Patients single center CD19-targeted for relapsing lymphoma were prospectively followed up by neurologists. Before T-cell...
Abstract Objective Emotion recognition tests are essential for differential diagnostics when assessing patients with Alzheimer’s disease (AD) dementia. However, there remains a lack of emotion appropriate culturally and educationally diverse populations. The aim this study was to develop an test (the TIE-93) these We then examined whether the TIE-93 could reduce performance differences between populations native French versus background (participants who had immigrated France). This assessed...
Importance Blood phosphorylated tau 217 (p-tau217) showed good performance in predicting brain amyloidosis. However, the importance of detailed cognitive phenotyping patients without dementia when interpreting p-tau217 results remains unclear. Objective To assess whether accuracy, negative predictive value (NPV), and positive (PPV) amyloidosis using varies across clinical presentations dementia. Design, Setting, Participants The study design included 2 observational, prospective cohort...
To assess the role of biomarkers Alzheimer disease (AD), neurodegeneration, and small vessel (SVD) as mediators in association between diabetes mellitus cognition. The study sample was derived from MEMENTO, a cohort French adults recruited memory clinics screened for either isolated subjective cognitive complaints or mild impairment. Diabetes defined based on blood glucose assessment, use antidiabetic agent, self-report. We used structural equation modeling to whether latent variables AD...
To assess subclinical central nervous system (CNS) involvement in primary Sjögren syndrome (pSS), by comparing standard brain MRI, in-depth neuropsychological testing and (99m)Tc-ECD single-photon emission computed tomography (SPECT) of patients with pSS matched controls.10 women (<55 years old), defined using European-American criteria, presence anti-SSA and/or anti-SSB antibodies no history neurological were prospectively investigated, compared 10 age- sex-matched controls. All subjects...
Despite surgery, radiotherapy (RT) and temozolomide (TMZ), the prognosis of glioblastoma (GBM) patients remains dismal. Normally prescribed with aim to lower blood pressure, angiotensin-II (Ang-II) inhibitors were reported reduce angiogenesis tumour growth in several models including one glioma. Thus whether treatment Ang-II could be associated a better clinical outcome GBM was investigated.A series 81 consecutive patients, homogeneously treated RT TMZ for newly diagnosed, supratentorial...
To validate the TNI-93 test in illiterate and low-educated subjects by setting cutoff scores to discriminate non-demented demented a clinical (CESILL) verifying adequacy of these population-based study (AMI cohort).We used two samples. First, comprising normal elderly participants patients, mostly multicultural, low educated, or illiterate, was compute for detection dementia. Second, AMI cohort, cohort retired farmers living rural setting, as replication study, assess properties different...
Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a promising treatment in relapsing B-cell lymphoma but frequently associated with acute neurotoxicity. Neurologic long-term safety has not been thoroughly assessed.All patients consecutive refractory admitted our center for CAR underwent neurologic examination, extensive neuropsychological assessment, and brain MRI (except 1 patient) completed self-administrated questionnaires at baseline. The who remained disease-free 2 years were...
The standard of care in patients with glioblastoma (GBM) relies on surgical resection, radiation therapy (RT), and temozolomide. Steroids are required almost all to reduce peritumoral edema, but associated numerous side effects. Vascular endothelial growth factor (VEGF) is a key driver edema angiogenesis human GBM. Recently, angiotensin-II inhibitors were reported VEGF secretion tumor some animal models.To investigate whether might have similar effect humans before undertaking prospective...
TLR-9 agonists are immunostimulating agents that have antitumor effects in animal models. A phase I trial was conducted to define the safety profile of subcutaneous injections, combined with intrathecally administration CpG-28, a TRL 9 agonist, patients neoplastic meningitis (NM). Cohorts 3-6 NM were treated for 5 weeks escalating doses CpG-28. The primary endpoint tolerance. Secondary endpoints progression free survival (PFS) and overall (OS). Twenty-nine cancers malignant glioma, lung...
Immune-checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte-associated antigen-4 and programmed cell death ligand-1) are associated with several immune-related neurological disorders. Cases of meningitis related to ICIs poorly described in literature probably underestimated. Several guidelines available for the acute management these adverse events, but safety resuming patients remains unclear. We conducted a retrospective case series that occurred between October 1 2015 31 2019 two...
To compare the administration of neuropsychological tests by teleneuropsychology (TeleNP) and face to (F-F) in order determine feasibility reliability TeleNP. At inclusion visit, all participants underwent a traditional F-F assessment as part their standard care. Four months after inclusion, they were randomized undergo an additional either or A total 150 adults with cognitive complaints, but no major sensorial impairment included. 4 months, 69 arm 71 TeleNP (10 lost follow-up). The overall...