A5074346275- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Sleep and related disorders
- Aging, Elder Care, and Social Issues
- Health, Medicine and Society
- Stroke Rehabilitation and Recovery
- Sleep and Wakefulness Research
- Hearing Loss and Rehabilitation
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Neurological Disorders and Treatments
- Psychoanalysis and Psychopathology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Schizophrenia research and treatment
- Congenital Heart Disease Studies
- Advanced Chemical Sensor Technologies
- Neurological disorders and treatments
- Healthcare Systems and Practices
- Restless Legs Syndrome Research
- Health disparities and outcomes
Centre Hospitalier Universitaire de Nice
2016-2025
Rady Children's Hospital-San Diego
2025
Universidad Europea Miguel de Cervantes
2023-2025
Université Paris Cité
2024-2025
Sorbonne Paris Cité
2024-2025
Université Côte d'Azur
2014-2024
Université de Rennes
2023-2024
Centre de Recherche en Archéologie, Archéosciences, Histoire
2024
Foundation for Polish Science
2023-2024
Cognition Behaviour Technology
2013-2023
To evaluate the interest of using automatic speech analyses for assessment mild cognitive impairment (MCI) and early-stage Alzheimer's disease (AD).Healthy elderly control (HC) subjects patients with MCI or AD were recorded while performing several short vocal tasks. The voice recordings processed, first markers extracted signal processing techniques. Second, tested to assess their "power" distinguish among HC, MCI, AD. second step included training classifiers detecting AD, machine learning...
Abstract Background: Apathy is a very common behavioural and psychological symptom across brain disorders. In the last decade, there have been considerable advances in research on apathy motivation. It thus important to revise diagnostic criteria published 2009. The main objectives were to: a) definition of apathy; b) update list dimensions; c) operationalise criteria; d) suggest appropriate assessment tools including new technologies. Methods: expert panel (N = 23) included researchers...
Virtual Reality (VR) has emerged as a promising tool in many domains of therapy and rehabilitation, recently attracted the attention researchers clinicians working with elderly people MCI, Alzheimer’s disease related disorders. Here we present study testing feasibility using highly realistic image-based rendered VR patients MCI dementia. We designed an attentional task to train selective sustained attention, tested paper version this single-session within-subjects design. Results showed that...
Gait disturbance is an early feature in Parkinson's disease. Its pathophysiology poorly understood; however, cholinergic dysfunction may be a non-dopaminergic contributor to gait. Short-latency afferent inhibition surrogate measure of activity, allowing the contribution gait evaluated. We hypothesized that short-latency would independent predictor Twenty-two participants with disease and 22 age-matched control subjects took part study. was measured objectively using instrumented walkway...
Recently there has been a growing interest in employing serious games (SGs) for the assessment and rehabilitation of elderly people with mild cognitive impairment (MCI), Alzheimer's disease (AD), related disorders. In present study we examined acceptability 'Kitchen cooking' - SG developed context EU project VERVE (http://www.verveconsortium.eu/) these populations. this game cooking plot is employed to assess stimulate executive functions (such as planning abilities) praxis. The installed on...
Various types of dementia and Mild Cognitive Impairment (MCI) are manifested as irregularities in human speech language, which have proven to be strong predictors for the disease presence progress ion. Therefore, automatic analytics provided by a mobile application may useful tool providing additional indicators assessment detection early stage MCI.165 participants (subjects with subjective cognitive impairment (SCI), MCI patients, Alzheimer's (AD) mixed (MD) patients) were recorded while...
Abstract In response to the COVID-19 pandemic, many governments have taken drastic measures avoid an overflow of intensive care units. Accurate metrics disease spread are critical for reopening strategies. Here, we show that self-reports smell/taste changes more closely associated with hospital overload and earlier markers infection SARS-CoV-2 than current governmental indicators. We also report a decrease in new onset as early 5 days after lockdown enforcement. Cross-country comparisons...
Hearing impairment is common among older adults and affects cognitive assessments for identification of dementia which rely on good hearing function. We developed validated a version the Montreal Cognitive Assessment (MoCA) people with impairment.We adapted existing MoCA 8.1 items by presenting instructions stimuli in written rather than spoken format. One Attention domain two Language required substitution alternative items. Three four candidate respectively were constructed field-tested...
Apathy and depression are the most frequent neuropsychiatric symptoms in Alzheimer's disease (AD). In a cross-sectional observational study of 734 subjects with probable mild AD, we evaluated prevalence apathy depression. After use
The use of Serious Games (SG) in the health domain is expanding. In field neurodegenerative disorders (ND) such as Alzheimer's disease, SG are currently employed both to support and improve assessment different functional cognitive abilities, provide alternative solutions for patients' treatment, stimulation, rehabilitation. As quite young, recommendations on people with ND still rare. 2014 we proposed some initial (Robert et al., 2014). aim present work was update them, thanks opinions...
Methods: The aim of the study is to propose a daily activity scenario (DAS) score that detects functional impairment using ICTs in AD and MCI compared with normal control group (NC). Sixty-four participants over 65 years old were included: 16 matched 10 NC for protocol 1 (P1) 19 2 (P2). Each participant was asked undertake set tasks setting "smart home" equipped two video cameras everyday objects use activities living (8 IADLs P1 11 P2, plus 4 temporal execution constraints). DAS then...
The natural history and disease mechanisms of Alzheimer's related disorders (ADRD) are still poorly understood. Very few resources available to scrutinise patients as early needed use integrative approaches combining standardised, repeated clinical investigations cutting-edge biomarker measurements.In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics screened for either isolated subjective cognitive complaints (SCCs) or mild impairment (MCI; defined...
Background: Neuropsychiatric symptoms, also known as behavioral and psychological symptoms of dementia (BPSD), affect the majority patients with dementia, result in a greater cognitive functional impairment. Objective: To investigate associations between BPSD amyloid cerebral deposition measured by 18F-Florbetapir-PET quantitative uptake elderly subjects without Methods: Participants impairment [mild (MCI) or Alzheimer’s disease (AD)] healthy controls (HC) from ADNI cohort (Alzheimer Disease...
Abstract Study Objectives Sleep changes have been associated with increased risks of developing cognitive disturbances and Alzheimer’s disease (AD). A bidirectional relation is underlined between amyloid-beta (Aß) sleep disruptions. The profile in participants at risk to develop AD not fully deciphered. We aim investigate sleep–wake objective measurements elderly without impairment depending on their brain amyloid status, positive (Aß+) or negative (Aß−) based standard absorption ratios...
To assess the role of biomarkers Alzheimer disease (AD), neurodegeneration, and small vessel (SVD) as mediators in association between diabetes mellitus cognition. The study sample was derived from MEMENTO, a cohort French adults recruited memory clinics screened for either isolated subjective cognitive complaints or mild impairment. Diabetes defined based on blood glucose assessment, use antidiabetic agent, self-report. We used structural equation modeling to whether latent variables AD...
Isolated subjective cognitive impairment (SCI) and mild (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study patients SCI MCI clinic, neuropsychology, biology, brain imaging data. We aimed to compare symptoms DLB others in this at baseline.Participants French cohort were recruited for either or MCI. Among them, 892 included sub-study, designed search specifically DLB. Probable diagnosis (pro-DLB group) was done using two-criteria cutoff score among...
Previous omics research in patients with complex congenital heart disease and single-ventricle circulation (irrespective of the stage palliative repair) revealed alterations cardiac systemic metabolism, inter alia abnormalities energy inflammation, oxidative stress or endothelial dysfunction. We employed an affinity-proteomics approach focused on cell surface markers, cytokines, chemokines serum 20 adult Fontan a good functioning left ventricle, we matched controls to reveal any specific...
Apathy is the most frequently reported neuropsychiatric symptom across all stages of Alzheimer's disease (AD). Both apathy and sleep disorders are known to have independent negative effects on quality life in individuals with AD. The aim th
Over the last few years, use of new technologies for support elderly people and in particular dementia patients received increasing interest. We investigated a video monitoring system automatic event recognition assessment instrumental activities daily living (IADL) patients. Participants (19 healthy subjects (HC) 19 mild cognitive impairment (MCI) patients) had to carry out standardized scenario consisting several IADLs such as making phone call while they were recorded by 2D cameras. After...
Objective This study aimed to evaluate the effectiveness of a nursing home (NH) staff education manage apathy in older individuals with diagnosis dementia. Methods Sixteen NHs agreed participate, and 230 demented apathetic residents were randomly assigned reference group (RG) or intervention (IG). IG received month weekly 4‐h training. Qualitative evaluation was performed through interviews questionnaires regarding work practices knowledge about Quantitative at baseline, end training program...