A5044218016- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sleep and related disorders
- Cerebral Palsy and Movement Disorders
- Advanced MRI Techniques and Applications
- Sleep and Wakefulness Research
- Genetic Associations and Epidemiology
- Posttraumatic Stress Disorder Research
- Musculoskeletal pain and rehabilitation
- Veterinary Equine Medical Research
- Brain Tumor Detection and Classification
- Veterinary Orthopedics and Neurology
- Trace Elements in Health
- Cardiac Arrest and Resuscitation
- Health, Environment, Cognitive Aging
- Prion Diseases and Protein Misfolding
- Bioinformatics and Genomic Networks
- EEG and Brain-Computer Interfaces
- Machine Learning in Bioinformatics
Stanford University
2016-2025
VA Palo Alto Health Care System
2015-2024
Arizona State University
2023
Mayo Clinic in Florida
2023
Palo Alto Veterans Institute for Research
2021-2022
Palo Alto University
2019
JDSU (United States)
2018
Brigham Young University
2016
University of California, San Francisco
2010-2011
University of California, Berkeley
2006-2011
Abstract Objective Alzheimer's disease (AD) is found at autopsy in up to one third of patients with primary progressive aphasia (PPA), but clinical features that predict AD pathology PPA are not well defined. We studied the relationships between language presentation, Aβ amyloidosis, and glucose metabolism three variants using [ 11 C]‐Pittsburgh compound B ([ C]PIB) 18 F]‐labeled fluorodeoxyglucose positron emission tomography F]FDG‐PET). Methods Patients meeting criteria (N = 15) were...
The PET tracer (11)C-labeled Pittsburgh Compound-B ((11)C-PIB) specifically binds fibrillar amyloid-beta (Abeta) plaques and can be detected in Alzheimer disease (AD). We hypothesized that imaging with (11)C-PIB would discriminate AD from frontotemporal lobar degeneration (FTLD), a non-Abeta dementia.Patients meeting research criteria for (n = 7) or FTLD 12) cognitively normal controls 8) underwent (patients controls) (18)F-fluorodeoxyglucose ((18)F-FDG) only). whole brain region of interest...
We use a novel balanced experimental design to specifically investigate brain mechanisms underlying the modulating effect of expected pain intensity on afferent nociceptive processing and perception. used two visual cues, each conditioned one noxious thermal stimuli [∼48°C (high) or 47°C (low)]. The cues were presented just before during application stimulus. Subjects reported significantly higher when stimulus was preceded by high-intensity cue. To control for expectancy effects, one-half...
To compare the diagnostic performance of PET with amyloid ligand Pittsburgh compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD).Patients meeting clinical criteria for AD (n = 62) FTLD 45) underwent PiB FDG-PET. scans were classified as positive or negative by 2 visual raters blinded diagnosis, using a quantitative threshold derived from controls 25). FDG visually rated consistent FTLD,...
Patients with early age-of-onset Alzheimer's disease show more rapid progression, generalized cognitive deficits and greater cortical atrophy hypometabolism compared to late-onset patients at a similar stage. The biological mechanisms that underlie these differences are not well understood. purpose of this study was examine in vivo whether metabolic between early-onset associated the distribution burden fibrillar amyloid-beta. meeting criteria for probable (National Institute Neurological...
Background: Neuropsychiatric symptoms, also known as behavioral and psychological symptoms of dementia (BPSD), affect the majority patients with dementia, result in a greater cognitive functional impairment. Objective: To investigate associations between BPSD amyloid cerebral deposition measured by 18F-Florbetapir-PET quantitative uptake elderly subjects without Methods: Participants impairment [mild (MCI) or Alzheimer’s disease (AD)] healthy controls (HC) from ADNI cohort (Alzheimer Disease...
To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, human subjects with a prion protein (PrP) gene (PRNP) mutation that produces clinical syndrome similar to Alzheimer disease (AD).Amyloid imaging specific ligands offers great promise for early detection differential diagnosis AD. Genetic forms can present features resemble AD, at autopsy may show deposition mutant PrP-amyloid. FDDNP binds PrP-amyloid postmortem specimens, but has not been reported disease. The...
Evaluation of brainstem pathways with diffusion tensor imaging (DTI) and tractography may provide insights into pathophysiologies associated dysfunction key circuits. However, identification these tracts has been elusive, relatively few in vivo human studies to date. In this paper we proposed an automated approach for reconstructing nine fiber trajectories that might be involved pain modulation. We first performed native-space manual a small normative cohort participants confirmed the...
Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts most pertinent to diagnosis. This study ranked fiber on their ability discriminate patients with and without TBI. We acquired data from military veterans admitted a polytrauma clinic (Overall n = 109; Age: M 47.2, SD 11.3; Male: 88%; TBI: 67%)....
Understanding the pathophysiology of traumatic brain injury (TBI) is crucial for effectively managing care. Diffusion tensor imaging (DTI) an MRI technology that evaluates TBI pathology in white matter. However, DTI analysis generates numerous measures. Choosing between them remains obstacle to clinical translation. In this study, we leveraged iterative receiver operating characteristic (ROC) examine matter tracts a group 380 Veterans, consisting (n = 243) and non-TBI patients 137). For each...
Abstract Introduction Recent meta-analyses show that 30-70% of individuals with a history traumatic brain injury (TBI) suffer from persistent sleep disturbances. Further, more than 80% all TBI cases are mild (mTBI) and report insomnia those moderate-to-severe TBI. Given the positive track record Cognitive Behavioral Therapy for Insomnia (CBT-I) in other conditions, CBT-I could also be an effective treatment mTBI, despite common comorbidities. Methods In this RCT (NCT03261674) veterans...
This study used PET with the amyloid-β (Aβ) imaging agent 11 C Pittsburgh Compound-B (PIB) and glucose metabolic tracer 18F-fluorodeoxyglucose (FDG) to map relationship of Aβ deposition regional metabolism in Alzheimer's disease (AD). Comparison 13 AD patients' FDG scans healthy controls confirmed a typical temporo-parietal hypometabolic pattern AD. In contrast, PIB distribution-volume-ratios showed distinct specific retention fronto-temporo-parietal regions striatum peaks left frontal...
Abstract Objectives: We examined florbetapir positron emission tomography (PET) amyloid scans across stages of preclinical Alzheimer’s disease (AD) in cortical, allocortical, and subcortical regions. Stages were characterized using empirically defined methods. Methods: A total 312 cognitively normal Disease Neuroimaging Initiative participants completed a neuropsychological assessment PET scan. Participants classified into AD (1) novel approach based on the number abnormal...
Objective Given the high prevalence and comorbidity of combat-related PTSD TBI in Veterans, it is often difficult to disentangle contributions each disorder. Examining these pathologies separately may help understand neurobiological basis memory impairment independently other. Thus, we investigated whether a) are characterized by subcortical structural abnormalities examining diffusion tensor imaging (DTI) metrics volume b) if were specific versus TBI. Method We individuals with or display...
This supplement to the Journal of Alzheimer's Disease contains more than half chapters from The Handbook Imaging Alzheimer Brain, which was first presented at International Conference on in Paris, July, 2011.
Comparisons of white matter (WM) fractional anisotropy (FA) values between mild traumatic brain injury (mTBI) patients and controls have revealed inconsistencies in the directions resulting FA changes. To address these discrepancies, we examined hemispheric symmetry levels across WM tracts 150 mTBI relative to 96 military controls. Automated fiber quantification was used extract 18 with 100 values, which were compute correlation strengths nine bilateral tract pairs. The Fisher z-transformed...