A5087578031- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Telemedicine and Telehealth Implementation
- Cholinesterase and Neurodegenerative Diseases
- Treatment of Major Depression
- Aging and Gerontology Research
- Geriatric Care and Nursing Homes
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Health and Well-being Studies
- COVID-19 and Mental Health
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Text Readability and Simplification
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological Disorders and Treatments
- Health disparities and outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Apelin-related biomedical research
- Digital Mental Health Interventions
- Health and Wellbeing Research
- Obsessive-Compulsive Spectrum Disorders
National and Kapodistrian University of Athens
2016-2025
Johns Hopkins University
2016-2025
Eginition Hospital
2016-2025
Johns Hopkins Medicine
2006-2025
Democritus University of Thrace
2023
Hippocration General Hospital
2022
University of Manchester
2021
King's College London
2017-2021
University of Plymouth
2021
Greater Manchester Mental Health NHS Foundation Trust
2021
Abstract Background Apathy is a common symptom in patients with dementia and has adverse consequences for caregivers. Most treatments apathy, particularly non‐pharmacologic interventions, have not been evaluated controlled trials. Objectives This study the efficacy of kit‐based activity intervention, compared to time attention control (one‐on‐one meetings an therapist) reducing apathy improving quality life 37 dementia. Methods The design was randomized, controlled, partially masked clinical...
The use of Serious Games (SG) in the health domain is expanding. In field neurodegenerative disorders (ND) such as Alzheimer's disease, SG are currently employed both to support and improve assessment different functional cognitive abilities, provide alternative solutions for patients' treatment, stimulation, rehabilitation. As quite young, recommendations on people with ND still rare. 2014 we proposed some initial (Robert et al., 2014). aim present work was update them, thanks opinions...
Background: The outbreak of the COVID-19 pandemic seems to have mental health implications for both people with neurocognitive disorder and their caregivers. Objective: study aimed shed light on relations between caregiver reaction distress related neuropsychiatric symptoms, memory impairment progression, functional during period confinement in Greece. Methods: included caregivers patients mild (N = 13) major 54) disorder. caregiver-based telephone interview was based items inventory...
Objectives High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has proven antidepressant effects, but the optimal frequency of sessions remains unclear. Methods We conducted a 3-week, sham-controlled trial to assess efficacy 1 active HF-rTMS session per day (A1 group) compared with 2 (A2 and equivalent sham (once day, S1 group; twice S2 in patients treatment-resistant major depression subsequent 2-week follow-up period. One hundred seventy-seven were screened, whom 105 met...
Abstract Depressive symptoms are common in mild cognitive impairment (MCI), dementia caused by Alzheimer’s disease (AD dementia) and cognitively unimpaired older adults. However, it is unclear whether they could contribute to the identification of ageing. To assess potential utility depressive distinguish between healthy ageing MCI AD dementia. The diagnostic workup function 1737 individuals, 334 people with 142 individuals relied on a comprehensive neuropsychiatric assessment, including...
Illness behavior is influenced by subjective, social, and cultural factors can vary from one person to another even internally within the same individual depending on situation type of illness he or she needs deal with. The Attitude Scales (IAS) were designed Robert Kellner assess fears, negative beliefs, attitudes related hypochondriasis abnormal in relation illness, it a reliable tool for detecting them as does not contain items symptoms that are characteristic other psychiatric symptoms....
Clinical and preclinical studies firmly support the involvement of inflammation in pathogenesis Alzheimer's disease (AD). Despite acetylcholinesterase inhibitors (AChEI) being widely used AD patients, there is no conclusive evidence about their impact on inflammatory response.This study investigates peripheral proinflammatory cytokines (interferon gamma [IFN-γ], tumor necrosis factor alpha [TNF-α], interleukins 1β [IL-1β] 6 [IL-6]) by firstly comparing blood mononuclear cell (PBMC)-derived...
Major depression affects about 25% of patients with Alzheimer's disease (AD) and has serious adverse consequences for as well caregivers. Studies treatments in AD, like most treatment studies, depend on the ability scales used to measure outcome detect a difference between effects control, particularly trials conducted over waves.To compare three scales, some their subscales, drug (treatment) placebo (control).Comparison terms percent variance explained indicated by adjusted or partial...
The objective of this 12-week open-label study was to evaluate the efficacy, safety, and tolerability pregabalin as an adjunctive treatment antidepressants in older patients suffering from depression comorbid generalized anxiety disorder (GAD).The initial sample consisted 94 fulfilling criteria for with GAD who were treated antidepressants. Twenty them had received antidepressant monotherapy adequate time shown partial response prescribed, terms either or depressive symptomatology, followed...
<b><i>Background/Aims:</i></b> The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) detecting Alzheimer’s disease (AD) is still elusive. <b><i>Methods:</i></b> BACE1 sAβPPβ concentration were measured patients with AD dementia (<i>n</i> = 56) mild cognitive impairment (MCI) due to 76) abnormal routine CSF markers, MCI normal...
Up to 90% of people with dementia in long term care (LTC) have hearing and/or vision impairment. Hearing/vision difficulties are frequently under-recognised or incompletely managed. The impacts hearing/vision impairment include more rapid cognitive decline, behavioural disturbances, reduced quality life, and greater burden. This research investigated LTC staff knowledge, attitudes practice regarding needs for residents dementia.A survey facilities England, South Korea, India, Greece,...
Abstract Background Detecting impaired naming capacity is valuable in diagnosing neurocognitive disorders (ND). A. clinical practice- oriented overview of tests validated ND not available yet. Here, features with utility which are open access or for purchase succinctly presented and compared. Methods Searches were carried out across Pubmed, Medline Google Scholar. Additional studies identified by searching reference lists. Only peer-reviewed journal articles eligible. A narrative- tabullar...
Electroconvulsive therapy (ECT) is an effective treatment and, with the proper risk-minimizing strategies, relatively safe even in depressed patients cardiovascular diseases. Specifically, cardiac rhythm management devices (CRMDs) require particular attention because no controlled trials exist to support current empirical recommendations. We present a patient pacemaker successfully treated ECT, and we critically review relevant literature. Pooled results from 63 821 ECT sessions showed that...