A5013902226- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer-related cognitive impairment studies
- Peripheral Neuropathies and Disorders
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Herpesvirus Infections and Treatments
- Epigenetics and DNA Methylation
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
Hôpital Saint-Louis
2018-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Université Paris Cité
2018-2024
Sorbonne Paris Cité
2018-2024
Paris Cardiovascular Research Center
2020-2022
Université de Lille
2022
Inserm
2020-2022
Hôpital Européen Georges-Pompidou
2020-2021
Hôpital Européen
2020-2021
Délégation Paris 7
2018-2019
TP53-mutated (TP53m) myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) have very poor outcome irrespective of the treatment received, including 40% responses (20% complete remission [CR]) with azacitidine (AZA) alone, short response duration, a median overall survival (OS) approximately 6 months. Eprenetapopt (APR-246), novel first-in-class drug, leads to p53 protein reconformation reactivates its proapoptotic cell-cycle arrest functions.This phase II study assessed safety...
In a two-stage phase II study, 24 patients with first diagnosis of glioblastoma (GBM) were treated dendritic cell (DC) immunotherapy associated to standard radiochemotherapy temozolomide (TMZ) followed by adjuvant TMZ. Three intradermal injections mature DC loaded autologous GBM lysate administered before TMZ, while 4 performed during According Simon design, proceed the second stage progression-free survival (PFS) 12 months after surgery was expected in at least 8 cases enrolled stage....
Chimeric antigen receptor-modified T (CAR T) cells are profoundly changing the standard of care in B-cell malignancies. This new therapeutic class induces a significant number acute neurotoxicity, but data regarding mid- and long-term neurological safety scarce. We evaluated mid-term safety, with special emphasis on cognitive functions, series adults treated CAR cells.Patients single center CD19-targeted for relapsing lymphoma were prospectively followed up by neurologists. Before T-cell...
Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a promising treatment in relapsing B-cell lymphoma but frequently associated with acute neurotoxicity. Neurologic long-term safety has not been thoroughly assessed.All patients consecutive refractory admitted our center for CAR underwent neurologic examination, extensive neuropsychological assessment, and brain MRI (except 1 patient) completed self-administrated questionnaires at baseline. The who remained disease-free 2 years were...
Immune-checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte-associated antigen-4 and programmed cell death ligand-1) are associated with several immune-related neurological disorders. Cases of meningitis related to ICIs poorly described in literature probably underestimated. Several guidelines available for the acute management these adverse events, but safety resuming patients remains unclear. We conducted a retrospective case series that occurred between October 1 2015 31 2019 two...
PURPOSE The Lynch syndrome (LS)-glioma association is poorly documented. As for mismatch repair deficiency (MMRd) in glioma, a hallmark of LS-associated tumors, there are only limited data available. We determined MMRd and LS prevalence large series unselected gliomas, explored the associated characteristics. Both have major implications terms treatment, screening, prevention. METHODS Somatic next-generation sequencing was performed on 1,225 treatment-naive adult gliomas referred between...
PURPOSE Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3 IDHmt/Codel ) benefit from adding alkylating agent chemotherapy to radiotherapy (RT). However, the optimal regimen between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vincristine (PCV) temozolomide (TMZ) remains unclear given lack of randomized trial data comparing both regimens. METHODS The objective was assess overall survival (OS) progression-free (PFS) associated first-line PCV/RT...
A.F. Carpentier has served as a consultant for BMS; C. Lebbe is BMS and MSD. The other authors have declared no conflict of interest.
2004 Background: Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3 IDHmt/Codel ) benefit from adding alkylating chemotherapy to radiotherapy (RT). However, the optimal regimen between Procarbazine, CCNU, and Vincristine (PCV) Temozolomide (TMZ) remains unclear given lack of randomized trial data comparing both regimens. Methods: The objective was assess overall (OS) progression-free (PFS) survival associated first-line PCV/RT versus TMZ/RT in patients diagnosed O3 . We...
2005 Background: TERT, a subunit of the telomerase complex, is largely expressed in almost all cancers. Among those cancers, glioblastomas (GBM) harbor highest incidence activating mutations within TERT promoter (over 85% patients). This high underlies potential role oncogenesis, and points out as highly relevant tumor target GBM. UCPvax therapeutic vaccine composed two CD4 helper peptides derived from combined with montanide adjuvant. We conducted phase IIa trial to test immunogenicity,...
Few data are available on patients with leptomeningeal disease (LM) from melanoma treated new systemic therapies. To gain a better understanding of patients, characteristics, and therapeutic interventions in LM the era treatment. Clinical treatments, survival diagnosed LM, isolated or associated brain metastases, were collected. The Cox regression model assessed influence patient characteristics survival. Monocentric, retrospective, real-life cohort melanoma. All followed up at Saint-Louis...