Romuald Seizeur
A5041697969- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Peripheral Nerve Disorders
- Advanced Neuroimaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Nerve Injury and Rehabilitation
- Neuroblastoma Research and Treatments
- Orthopedic Surgery and Rehabilitation
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Anatomy and Medical Technology
- Advanced MRI Techniques and Applications
- Reconstructive Surgery and Microvascular Techniques
- Bone Tumor Diagnosis and Treatments
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Surgical Simulation and Training
- Spine and Intervertebral Disc Pathology
- Ophthalmology and Eye Disorders
- Fetal and Pediatric Neurological Disorders
- Health, Medicine and Society
Laboratoire de Traitement de l'Information Médicale
2012-2024
Université de Bretagne Occidentale
2013-2024
Centre Hospitalier Régional Universitaire de Brest
2015-2024
Inserm
2010-2024
Hôpital Maison Blanche
2008-2024
Hospices Civils de Lyon
2024
Hôpital Nord
2024
Peuplements végétaux et bioagresseurs en milieu tropical
2024
Centre Hospitalier Universitaire Amiens-Picardie
2024
Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique
2006-2022
PURPOSE Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3 IDHmt/Codel ) benefit from adding alkylating agent chemotherapy to radiotherapy (RT). However, the optimal regimen between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vincristine (PCV) temozolomide (TMZ) remains unclear given lack of randomized trial data comparing both regimens. METHODS The objective was assess overall survival (OS) progression-free (PFS) associated first-line PCV/RT...
The authors report on 2 cases of delayed compression the cervical spinal cord by dense scar tissue forming around epidural electrodes implanted for stimulation (SCS). This complication has not been previously reported. Myelopathy developed in patients 5 and 16 years after surgical placement a electrode. Prior to myelopathy, both experienced tolerance phenomenon. Magnetic resonance imaging showed severe At surgery, thick surrounding electrode compressing posterior aspect was discovered. Both...
<div>AbstractPurpose:<p>Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There limited data on the clinical course affected patients.</p>Experimental Design:<p>We conducted an international retrospective cohort study patients with TRK fusion–driven tumors.</p>Results:<p>A total 119 were identified. The median age at time diagnosis was 4.5 years. majority reported to have a histology consistent...
<p>Supplementary Figure S1. Diagram of population patients.</p>
<p>Supplementary Figure S2. A) Hazard ratio for progression or death according to clinical characteristics. B) LGG: Low-grade glioma, HGG: High-grade glioma</p>
<p>Supplementary Data S1. Definition of response, Description response criteria used by sites to evaluate tumor extend resection, resection sites.</p>
Abstract Background In the POLA cohort, 3 pathological groups of CNS WHO grade oligodendroglioma IDH-mutant and 1p/19q co-deleted have been described: group 1 (high mitotic count only), 2 (microvascular proliferation MVP no necrosis), (MVP necrosis). Methods 494 patients from with a median follow-up 96 months were included. To identify impact contrast enhancement (CE) in on overall survival (OS) or progression-free (PFS), curves obtained (Kaplan–Meier method) compared (log-rank test). The...
Recent studies highlight the contribution of antiplatelet therapy to clinical severity and increased mortality intracerebral hemorrhage (ICH) but results are discrepant. The aim this report was evaluate association between drug use preceding onset ICH mortality, assessed at regular intervals, among patients with acute ICH. We analyzed data from a randomized study which enrolled consecutive documented efficacy intermittent pneumatic compression legs in venous thrombosis prevention. Clinical...
Animal studies have shown that Listeria monocytogenes can probably access the brain through a peripheral intraneural route, and it has been suggested similar process may occur in humans. However, thus far, its spreading central nervous system (CNS) not completely elucidated. The authors present case of multiple L. cerebral abscesses characterized by pattern distribution spread along white matter fiber tracts reviewed literature to identify other cases for analysis. They elected include only...
Abstract Background Based on preclinical studies showing that IDH-mutant (IDHm) gliomas could be vulnerable to PARP inhibition we launched a multicenter phase 2 study test the efficacy of olaparib monotherapy in this population. Methods Adults with recurrent IDHm high-grade (HGGs) after radiotherapy and at least one line alkylating chemotherapy were enrolled. The primary endpoint was 6-month progression-free survival rate (PFS-6) according response assessment neuro-oncology criteria....
Objective: Chronic subdural haematomas (CSDH) is a common pathology that usually affects the elderly population. The incidence of CSDH has recently been increasing with expansion aging objective our study was to evaluate outcome following surgical drainage in patients.Materials and methods: We performed retrospective analysis 455 consecutive patients CSDHs over 5-year period. Among them, all 121 older than 80-year old were included study. Clinical status, comorbidities, type technique...