A5071467065- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Neuroendocrine Tumor Research Advances
- Head and Neck Surgical Oncology
- CNS Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Ocular Oncology and Treatments
- Spinal Fractures and Fixation Techniques
- Cancer Treatment and Pharmacology
- Epilepsy research and treatment
- MRI in cancer diagnosis
- Cancer-related Molecular Pathways
- Cerebrospinal fluid and hydrocephalus
- Lymphoma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Inserm
1999-2024
Université de Bordeaux
2013-2024
Centre National de la Recherche Scientifique
2006-2024
Sorbonne Université
2014-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Hôpital Pellegrin
2010-2021
Centre Hospitalier Universitaire de Nice
2021
Bordeaux Population Health
2011-2019
Service de la Santé Publique
2019
There is no community standard for the treatment of glioblastoma in patients 70 years age or older. We conducted a randomized trial that compared radiotherapy and supportive care with alone such patients.Patients older newly diagnosed anaplastic astrocytoma Karnofsky performance score higher were randomly assigned to receive only plus (focal radiation daily fractions 1.8 Gy given 5 days per week, total dose 50 Gy). The primary end point was overall survival; secondary points progression-free...
This report, an audit requested by the French government, describes oncological patterns of care, prognostic factors, and survival for patients with newly diagnosed histologically confirmed glioblastoma multiforme (GBM) in France. The Brain Tumor DataBase, which is a national multidisciplinary (neurosurgeons, neuropathologists, radiotherapists, neurooncologists, epidemiologists, biostatisticians) network, prospectively collected initial data cases GBM 2004, specific card was used to...
<h3></h3> The carcinogenic effect of radiofrequency electromagnetic fields in humans remains controversial. However, it has been suggested that they could be involved the aetiology some types brain tumours. <h3>Objectives</h3> objective was to analyse association between mobile phone exposure and primary central nervous system tumours (gliomas meningiomas) adults. <h3>Methods</h3> CERENAT is a multicenter case-control study carried out four areas France 2004–2006. Data about use were...
Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis; however, precise molecular mechanisms underlying this phenomenon remain elusive. Herein, we identified circadian clock PER1 mRNA as novel substrate of endoribonuclease activity UPR sensor IRE1α. Analysis mechanism shows that IRE1α decreased tumor cells without affecting gene transcription. Inhibition signaling using either siRNA-mediated silencing or dominant-negative strategy prevented decay, reduced...
Context: Neither precise evaluation of pertinent thresholds nor comparison the diagnostic performance late-night salivary cortisol (NSC) between inpatient and outpatient settings has been conducted. The usefulness NSC for screening "subclinical" Cushing's syndrome is still unknown. Objectives: aim study was to compare influence on assess its as a test subclinical syndrome. Design: Consecutive patients were investigated prospectively with two collections, first inpatients then outpatients....
INTRACRANIAL MENINGIOMA SURGERY IN THE NINTH DECADE OF LIFE Get access Oumar Sacko, M.D., M.D. 1Department of Neurosurgery, Pellegrin University Hospital, Bordeaux, France *Reprint requests: Department Place Amélie Raba Léon, 33076 France. Email: oumarsacko36@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar Musa Sesay, 2Department Anesthesiology, Franck-Emmanuel Roux, Ph.D., Ph.D. 3Department Hôpital Purpan, Toulouse, Tanguy Riem, Bruno Grenier, 4Department...
Abstract Vascular endothelial growth factor (VEGF) inhibitors are the most promising anti‐angiogenic agents used increasingly in clinic. However, to be efficient, anti‐VEGF need associated with classic chemotherapy. Exploring gene regulation tumor cells during anti‐angiogenesis might help comprehend molecular basis of response treatment. To generate a defined condition vivo , we transfected human glioma short‐interfering RNAs against VEGF‐A and implanted them on chick chorio‐allantoic...
Brain tumours are often disabling and rapidly lethal; their aetiology is largely unknown. Among potential risk factors, pesticides suspected.To examine the relationship between exposure to brain in adults a population-based case-control study southwestern France.Between May 1999 April 2001, 221 incident cases of 442 individually matched controls selected from general population were enrolled. Histories occupational environmental exposures, medical lifestyle information collected. A...
An increase in the incidence of CNS tumors has been observed many countries last decades. The reality this trend much debated, as it happened during a period when computer-assisted tomography and MRI have dramatically improved detection these tumors. Gironde Tumor Registry provides here first data on tumor trends France for all histological types, including benign malignant tumors, 2000–2007. Incidence rates were calculated globally each subtype. For trends, piecewise log-linear model was...
Abstract Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups currently distinguished on the basis IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis transcriptome, genome methylome 156 OT. Not only does our multi-omics classification match current but also reveals three within co-deleted tumours, associated with specific expression patterns nervous system cell types: oligodendrocyte, oligodendrocyte precursor (OPC) neuronal...
Brain metastases (BM) from differentiated thyroid carcinoma (DTC) are uncommon, and many questions about their management remain unsolved. The objective of this retrospective study was to analyze the characteristics, treatments, outcomes patients with BM DTC.Among 1523 a DTC prospectively recorded in institutional databases between 1989 2012, 21 (1.4%) were retrospectively retrieved. Patient histological findings on initial thyroidectomy specimen, time death reviewed. Overall survival (OS)...
Following recent studies underlining the differences between de novo and secondary anaplastic meningiomas prognostic value of telomerase reverse transcriptase (TERT) promoter mutation, we decided to conduct a multicenter retrospective study address these questions determine specific factors in each 2 meningioma subgroups.Among 68 cases initially selected, only 57 were confirmed as after centralized pathological review. TERT mutation analysis was performed all cases.Median overall survival...
The diagnosis of anaplastic meningioma (AM) (WHO grade III) is based on the presence a high mitotic index (MI) and/or overt anaplasia. Only few data exist about reproducibility and prognostic value Additionally, H3K27me3 loss in AM has not yet been demonstrated. Our objectives were to evaluate WHO criteria multicenter series 66 AM. Interobserver was good for determination (Kappa = 0.671) MI (intraclass correlation coefficient [ICC] 0.649), fair assessment anaplasia 0.366). Patients with...
OBJECTIVE Only one phase III prospective randomized study, published in 2006, has assessed the performance of 5-aminolevulinic acid (5-ALA) fluorescence–guided surgery (FGS) for glioblastoma resection. The aim RESECT study was to compare onco-functional results associated with 5-ALA fluorescence and white-light conventional microsurgery patients managed according current standards care. METHODS This a single-blinded involving 21 French neurosurgical centers, comparing FGS care, including...
Gliomas are the most common malignant primary brain tumors in adults. The median survival never exceeds 12 months, owing to inherent resistance both radio and chemotherapies. Epidermal Growth Factor Receptor (EGFR) is amplified, overexpressed, and/or mutated glioblastomas (GBM), making it a rational for therapy. Erlotinib, an EGFR kinase inhibitor strongly associated with clinical response several cancers. Inhibition of cell proliferation induction apoptosis by erlotinib were investigated...
The aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs). 50 AO patients enrolled the French national network for high-grade oligodendroglial tumors were analyzed. genomic profiles IDH mutational statuses assessed using high-resolution single-nucleotide polymorphism arrays direct sequencing, respectively. gene expression 25 1p/19q-codeleted AOs studied on Affymetrix arrays. Most cases frontal lobe contrast-enhanced (52%), but...