Clovis Adam
A5000224482- Glioma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neuroblastoma Research and Treatments
- Cellular transport and secretion
- Hereditary Neurological Disorders
- Brain Metastases and Treatment
- Vasculitis and related conditions
- Myasthenia Gravis and Thymoma
- Meningioma and schwannoma management
- Salivary Gland Disorders and Functions
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- Ocular Oncology and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Thermal Regulation in Medicine
- Autoimmune Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroendocrine Tumor Research Advances
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Adrenal and Paraganglionic Tumors
Bicêtre Hospital
2016-2025
Université Paris-Saclay
2020-2025
Inserm
2011-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Centre de Recherche en Cancérologie de Lyon
2024
Université Claude Bernard Lyon 1
2012-2024
Centre National de la Recherche Scientifique
2012-2024
Centre Hospitalier Régional et Universitaire de Nancy
2024
Hospices Civils de Lyon
2014-2024
Hôpital Nord
2024
Abstract Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. Experimental Design: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients using high-resolution single-nucleotide polymorphism (SNP) arrays (n = 29) whole-exome sequencing 4) approaches. Recurrent homozygous deletions somatic gene mutations found were validated by quantitative real-time PCR...
// Aurélie Bruno 1,2,3,4 , Blandine Boisselier 1,2,3,4,5 Karim Labreche Yannick Marie 5,6 Marc Polivka 7 Anne Jouvet 8 Clovis Adam 9 Dominique Figarella-Branger 10 Catherine Miquel 11 Sandrine Eimer 12 Caroline Houillier 13 Carole Soussain 14 Karima Mokhtari 1,2,3,4,6 Romain Daveau 15 and Khê Hoang-Xuan 1,2,3,4,13 1 Sorbonne Universités, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France 2 Institut National de la Santé et Recherche Médicale, U1127, 3...
Objective To compare the natural history of familial transthyretin amyloid polyneuropathies (FAP) due to Val30Met, Ser77Tyr, and Ile107Val mutations in France with classical Portuguese Val30Met FAP. Methods We compared 84 French patients a control group 110 carrying mutation also living France, all referred followed at National FAP Reference Center from 1988 2010. Clinical examination, functional walking disability scores, nerve conduction studies, muscle biopsies are reported. conducted...
In this study, biologically synthesized iron oxide nanoparticles, called magnetosomes, are made fully biocompatible by removing potentially toxic organic bacterial residues such as endotoxins at magnetosome mineral core surfaces and coating surface with poly-L-lysine, leading to magnetosomes-poly-L-lysine (M-PLL). M-PLL antitumor efficacy is compared that of chemically nanoparticles (IONPs) currently used for magnetic hyperthermia. IONPs tested the treatment glioblastoma, a dreadful cancer,...
OBJECTIVE The main limitation to the efficacy of chemotherapy for brain tumors is restricted access because limited permeability blood-brain barrier (BBB). Previous animal studies have shown that application pulsed ultrasound (US), in combination with intravenous injection microbubbles, can temporarily disrupt BBB deliver drugs normally cannot reach tissue. Although many previous been performed external focused US transducers, device described current work emits energy using an unfocused...
Primary central nervous system lymphoma (PCNSL) is a rare and distinct entity within diffuse large B-cell presenting with variable response rates probably to underlying molecular heterogeneity.To identify characterize PCNSL heterogeneity facilitate clinical translation, we carried out comprehensive multi-omic analysis [whole-exome sequencing, RNA sequencing (RNA-seq), methylation features] in discovery cohort of 147 fresh-frozen (FF) immunocompetent PCNSLs validation formalin-fixed,...
Abstract Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups currently distinguished on the basis IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis transcriptome, genome methylome 156 OT. Not only does our multi-omics classification match current but also reveals three within co-deleted tumours, associated with specific expression patterns nervous system cell types: oligodendrocyte, oligodendrocyte precursor (OPC) neuronal...
To clearly define transthyretin familial amyloid polyneuropathies (TTR-FAPs) fulfilling definite clinical and electrophysiologic European Federation of Neurological Societies/Peripheral Nerve Society criteria for chronic inflammatory demyelinating polyneuropathy (CIDP).From a cohort 194 patients with FAP, 13 84 (15%) French ancestry had late-onset TTR-FAP. We compared presentation electrophysiology to CIDP POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes)...
Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study was to define landscape HGGs in adolescents and young adults (AYAs).We performed a multicentric retrospective 112 AYAs Ile-de-France neurosurgical units, treated between 1998 2013 analyze clinicoradiological histomolecular profiles. The inclusion criteria were age 15 25 years, histopathological HGG diagnosis, available clinical data, preoperative follow-up...
Abstract Background and purpose This study was undertaken to assess skin biopsy as a marker of disease onset severity in hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN), treatable disease. Methods In this single center retrospective study, Congo red staining intraepidermal nerve fiber density (IENFD) were evaluated symptomatic ATTRv‐PN patients asymptomatic TTR gene mutation carriers between 2012 2019. Non‐ATTRv subjects suspected small neuropathy who underwent during the...
Background Hereditary transthyretin amyloidosis is a life-threatening autosomal dominant systemic disease due to pathogenic TTR variants (ATTRv), mostly affecting the peripheral nerves and heart. The characterised by combination of symptoms, organ involvement histological amyloid deposition. available disease-modifying ATTRv treatments (DMTs) are more effective if initiated early. Pathological nerve conduction studies (NCS) results cornerstone large-fibre polyneuropathy diagnosis, but this...
Familial amyloidosis with polyneuropathy (FAP) in France have a large genetic heterogeneity 29 transthyretin (TTR) gene mutations; Met30-TTR is the most frequent one (62%); followed by Tyr77-TTR (11.8%) and Phe77-TTR (6.2%). Analysis of 60 FAP patients diagnosed during period 2008-2010 showed amyloid was initially suspected only 38% patients. TTR Met30 Portuguese ancestry different from non other variants geographical distribution clinical presentation. There are three additional phenotypes...
In animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to rapidity decrease in body temperature after resuscitation. Because total liquid ventilation (TLV) with temperature-controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed determine whether this could limit post-cardiac arrest syndrome rabbit model. We especially focused on neurological, cardiac, pulmonary, liver kidney dysfunctions.Anesthetized rabbits were submitted either...
Object The blood-brain barrier (BBB) is a major impediment to the intracerebral diffusion of drugs used in treatment gliomas. Previous studies have demonstrated that pulsed focused ultrasound (US) conjunction with microbubble contrast agent can be open BBB. To apply US-induced opening BBB clinical practice, authors designed an innovative unfocused US device implanted skull and transiently repeatedly during standard chemotherapy protocol. goal this preliminary work was study induced by...
The aim of this study was to correlate histological features and molecular characteristics in anaplastic oligodendrogliomas (AOs). 203 AO patients, enrolled the French national network POLA, were analyzed. genomic profiles 191 cases studied using arrays. IDH mutational status assessed by immunohistochemistry direct sequencing. 1p/19q codeletion present 79% associated with alpha-internexin expression (P < 10−4), IDH1/2 mutation chromosome 4 loss 10−3), better overall survival 10−4). Based on...
Abstract Purpose The molecular pathogenesis of growth hormone-secreting pituitary adenomas is not fully understood. Cytogenetic alterations might serve as alternative driver events in GNAS mutation–negative somatotroph tumors. Experimental Design We performed cytogenetic profiling obtained from 39 patients with acromegaly and four sporadic gigantism by using array comparative genomic hybridization analysis. explored intratumor DNA copy-number heterogeneity two tumor samples fluorescence situ...
Anaplastic oligodendroglioma (AO) are rare primary brain tumours that generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC FUBP1. We also identified recurrent TCF12 additional series of 83 AO. Overall, 7.5% mutated for TCF12, which encodes oligodendrocyte-related...
PURPOSE Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3 IDHmt/Codel ) benefit from adding alkylating agent chemotherapy to radiotherapy (RT). However, the optimal regimen between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vincristine (PCV) temozolomide (TMZ) remains unclear given lack of randomized trial data comparing both regimens. METHODS The objective was assess overall survival (OS) progression-free (PFS) associated first-line PCV/RT...
GIP-dependent Cushing's syndrome is caused by ectopic expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) in cortisol-producing adrenal adenomas or bilateral macronodular hyperplasias. Molecular mechanisms leading to GIPR tissue are not known. Here we performed molecular analyses on adrenocortical and hyperplasias obtained from 14 patients with one patient aldosteronism. all adenoma hyperplasia samples occurred through transcriptional activation a single allele the...
Total liquid ventilation provides ultrafast and potently neuro- cardioprotective cooling after shockable cardiac arrest myocardial infarction in animals. Our goal was to decipher the effect of hypothermic total on systemic cerebral response asphyxial using an original pressure- volume-controlled strategy rabbits.Randomized animal study.Academic research laboratory.New Zealand Rabbits.Thirty-six rabbits were submitted 13 minutes asphyxia, leading arrest. After resumption spontaneous...
We aimed to study the potential clinical relevance of 9p allelic loss, with or without copy number variation, in 1p/19q codeleted anaplastic oligodendroglial tumors (AOTs).This enrolled 216 patients AOT. The prognostic value loss was investigated using a French nation-wide prospective registry, POLA (prise en charge des tumeurs oligodendrogliales anaplasiques) and high-density single nucleotide polymorphism arrays. validated our results Repository Molecular Brain Neoplasia Data (REMBRANDT)...