A5064274245- Pleistocene-Era Hominins and Archaeology
- Evolution and Paleontology Studies
- Pluripotent Stem Cells Research
- Multiple Myeloma Research and Treatments
- Pacific and Southeast Asian Studies
- Reproductive Biology and Fertility
- Neonatal Respiratory Health Research
- CRISPR and Genetic Engineering
- Forensic Anthropology and Bioarchaeology Studies
- Renal and related cancers
- Primate Behavior and Ecology
- Biomedical Ethics and Regulation
- Wildlife Ecology and Conservation
- Glycosylation and Glycoproteins Research
- Tryptophan and brain disorders
- Geology and Paleoclimatology Research
- Tissue Engineering and Regenerative Medicine
- Reproductive System and Pregnancy
- Gene expression and cancer classification
- Paleontology and Evolutionary Biology
- Acute Myeloid Leukemia Research
- 3D Printing in Biomedical Research
- Ovarian function and disorders
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
Inserm
2016-2025
Université de Montpellier
2016-2025
Institute for Regenerative Medicine & Biotherapy
2015-2025
Centre Hospitalier Universitaire de Montpellier
2011-2025
Naturalis Biodiversity Center
2014-2024
Hôpital Saint Eloi
2013-2024
Laboratoire de Génétique Cellulaire
2024
Royal Surrey County Hospital
2024
Australian National University
2024
Institut du Thorax
2020
The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories myeloid and lymphoid malignancies.The investigation was performed 11 laboratories across three continents included 3,334 patients. An exploratory retrospective stage I designed for biomarker discovery generated whole-genome profiles from 2,143 patients with myelodysplastic syndromes. profiling-based diagnostic accuracy...
Direct reprogramming of somatic cells into induced pluripotent stem (iPSCs) provides a unique opportunity to derive patient-specific with potential applications in tissue replacement therapies and without the ethical concerns human embryonic (hESCs). However, cellular senescence, which contributes aging restricted longevity, has been described as barrier derivation iPSCs. Here we demonstrate, using an optimized protocol, that senescence is not limit age-related physiology reversible. Thus,...
BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially expressed between immature and mature oocytes cumulus cells. METHODS: Using oligonucleotide microarrays, genome-wide gene expression was studied in pooled or cells from patients who underwent IVF. RESULTS: In addition to known genes, such as DAZL, BMP15 GDF9, up-regulated 1514 genes. show that PTTG3 AURKC are respectively securin Aurora kinase...
BACKGROUNDThe adjunction of exogenous hormones for controlled ovarian stimulation (COS) may alter endometrial receptiveness. In order to identify the genes misregulated under COS, we compared endometrium gene expression profiles, from same patients, in a natural cycle and subsequent COS cycle.
Identification of new criteria for embryo quality is required to improve the clinical outcome in vitro fertilization. The aim this study was determine gene expression profile cumulus cells (CC) surrounding oocyte as biomarkers potential and identify genes be used prognostic indicators successful pregnancy. CC from single oocytes were analysed using DNA microarrays. Gene profiles associated with good embryonic pregnancy computed. We observed that issued developed into embryos a morphology had...
Summary Gene expression profiling has the potential to enhance current methods for diagnosis of haematological malignancies. Here, we present data on 204 analyses from an international standardization programme that was conducted in 11 laboratories as a prephase Microarray Innovations LEukemia (MILE) study. Each laboratory prepared two cell line samples, together with three replicate leukaemia patient lysates distinct stages: (i) 5‐d course protocol training, and (ii) independent proficiency...
Identification of new markers assessing endometrial receptivity may help in improving the clinical outcome IVF. This study aimed at identifying genes expressed human endometrium during implantation window that could be used as such markers.A series normoresponder patients (n = 31) underwent biopsies 62, 2 per patient) early secretory phase, days after LH surge (LH + 2) and mid-secretory phase 7) same natural cycle preceded a ICSI attempt for male infertility factor. Samples were analyzed...
Abstract Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in rodent pluripotent stem cells (PSCs), whereas fibroblast growth (FGF)-2 and activin/nodal required to sustain self-renewal human PSCs condition referred as the primed state. It unknown why LIF/STAT3 alone fails PSCs. Here we show that forced expression hormone-dependent STAT3-ER (ER, ligand-binding domain oestrogen receptor) combination with 2i/LIF tamoxifen allows escape from state enter...
The early steps of differentiation human B cells into plasma are poorly known. We report a transitional population CD20(low/-)CD38(-) preplasmablasts along memory in vitro. Preplasmablasts lack documented cell or (CD20, CD38, and CD138) markers, express CD30 IL-6R, secrete Igs at weaker level than do plasmablasts cells. These further differentiate CD20(-)CD38(high)CD138(-) then CD20(-)CD38(high)CD138(+) were fully characterized terms whole genome transcriptome profiling phenotype. coexpress...