A5062246969- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- RNA regulation and disease
- Sarcoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Neurosurgical Procedures and Complications
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Nanoplatforms for cancer theranostics
- Neuroblastoma Research and Treatments
- Cervical and Thoracic Myelopathy
- Advanced Neuroimaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Peptidase Inhibition and Analysis
Centre Hospitalier Universitaire de Rennes
2015-2025
Université de Rennes
2015-2025
Inserm
2015-2024
Oncogenesis Stress Signaling
2016-2024
Hôpital Pontchaillou
2010-2023
Centre Eugène Marquis
2017-2023
Centre Hospitalier de Saint-Malo
2023
University of Thessaly
2019
Garvan Institute of Medical Research
2016
Macquarie University
2016
Research Article8 January 2018Open Access Transparent process Dual IRE1 RNase functions dictate glioblastoma development Stéphanie Lhomond Université de Bordeaux, France Search for more papers by this author Tony Avril INSERM U1242, "Chemistry, Oncogenesis, Stress, Signaling", Rennes 1, Rennes, Centre Lutte Contre le Cancer Eugène Marquis, Nicolas Dejeans Konstantinos Voutetakis Institute of Biology, Medicinal Chemistry & Biotechnology, NHRF, Athens, Greece Department Biochemistry University...
The standard of care for newly diagnosed glioblastoma is maximal safe surgical resection, followed by chemoradiation therapy. We assessed carmustine wafer implantation efficacy and safety when used in combination with care. Included were adult patients (n = 354, group) without 433, during first resection protocol. Multivariate case-matched analyses (controlled propensity-matched cohort, 262 pairs patients) conducted. median progression-free survival was 12.0 months (95% CI: 10.7–12.6) the...
OBJECTIVE Only one phase III prospective randomized study, published in 2006, has assessed the performance of 5-aminolevulinic acid (5-ALA) fluorescence–guided surgery (FGS) for glioblastoma resection. The aim RESECT study was to compare onco-functional results associated with 5-ALA fluorescence and white-light conventional microsurgery patients managed according current standards care. METHODS This a single-blinded involving 21 French neurosurgical centers, comparing FGS care, including...
Ventriculitis, a dreaded complication of brain abscess, meningitis, and various neurosurgical procedures, has attracted limited attention in the medical literature.This is retrospective, single-center study. We screened files all patients who had imaging report that included word "ventriculitis" during years 2005-2019. Only with clinical, microbiological, features ventriculitis were included. Data collected through standardized questionnaire.Ninety-eight fulfilled inclusion criteria: 42...
Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as surrogate marker for variety of stem cells, including glioblastoma (GBM) cells (GSC). However, the molecular and cellular functions remain unclear.Experimental Design: The function in GBM was addressed using models from immortalized primary lines, vivo orthotopic mouse models, specimens' transcriptome associated with MRI features patients. expression silenced U251 complemented CD90-negative U87...
Susceptibility-weighted imaging (SWI) of brain tumors provides information about neoplastic vasculature and intratumoral micro- macrobleedings. Low- high-grade gliomas can be distinguished by SWI due to their different vascular characteristics. Fractal analysis allows for quantification these radiological differences a computer-based morphological assessment patterns.To show the feasibility on 3-T magnetic resonance distinguish kinds tumors.Seventy-eight patients affected histopathology...
Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features identify prognostic factors. Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, outcome data collected retrospectively. Forty-three patients with GGG (median age,...
Article12 March 2021Open Access Transparent process Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors Daria Sicari orcid.org/0000-0003-3847-129X Inserm U1242, University Rennes, France Centre de lutte contre le cancer Eugène Marquis, Search for more papers by this author Federica G Centonze Raphael Pineau Pierre-Jean Le Reste Neurosurgery Department, Hospital Luc Negroni orcid.org/0000-0002-6204-3917 Institut Génétique et Biologie Moléculaire Cellulaire,...
Chronic subdural hematoma (CSDH) is a common neurological pathology, especially in older patients. The actual "gold standard" of treatment surgical evacuation, with various techniques used across neurosurgical teams. Over the years, there has been growing evidence that inflammatory processes play major role pathogenesis CSDH. In context, use corticosteroids proposed alone or as an adjuvant to surgery. However, this practice remains very empirical and need for high-quality-of-evidence studies...
Abstract Background Intrinsic or environmental stresses trigger the accumulation of improperly folded proteins in endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells have evolved an adaptive mechanism named unfolded protein response (UPR) which is hijacked by tumor develop malignant features. Glioblastoma (GB), most aggressive and lethal primary brain tumor, relies on UPR sustain growth. We recently showed that IRE1 alpha (referred hereafter), 1 transducers, promotes...