A5073003396- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microtubule and mitosis dynamics
- Viral gastroenteritis research and epidemiology
- Cell Image Analysis Techniques
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
Inserm
2017-2021
Ollscoil na Gaillimhe – University of Galway
2017-2021
Université de Rennes
2017-2021
Centre Eugène Marquis
2021
Oncogenesis Stress Signaling
2017-2021
Research Article8 January 2018Open Access Transparent process Dual IRE1 RNase functions dictate glioblastoma development Stéphanie Lhomond Université de Bordeaux, France Search for more papers by this author Tony Avril INSERM U1242, "Chemistry, Oncogenesis, Stress, Signaling", Rennes 1, Rennes, Centre Lutte Contre le Cancer Eugène Marquis, Nicolas Dejeans Konstantinos Voutetakis Institute of Biology, Medicinal Chemistry & Biotechnology, NHRF, Athens, Greece Department Biochemistry University...
The unfolded protein response (UPR) is an adaptive signaling pathway activated in to endoplasmic reticulum (ER) stress. effectors of the UPR are potent transcription activators; however, some genes suppressed by ER stress at mRNA level. mechanisms underlying UPR-mediated gene suppression less known. Exploration effect on NK cells ligand expression found that group 2 member D (NKG2D) major histocompatibility complex class I polypeptide-related sequence A/B (MICA/B) inositol-requiring enzyme 1...
Abstract Raman spectroscopy is an imaging technique that has been applied to assess molecular compositions of living cells characterize cell types and states. However, owing the diverse species in challenges assigning peaks specific molecules, it not clear how interpret cellular spectra. Here, we provide firm evidence spectra (RS) transcriptomic profiles glioblastoma can be computationally connected thus interpreted. We find dimensions high‐dimensional RS transcriptomes reduced linearly...
Abstract Endoplasmic Reticulum (ER) proteostasis control and the Unfolded Protein Response (UPR ER ) have been shown to contribute tumor development aggressiveness. As such, UPR sensor IRE1α (referred as IRE1 hereafter) is a major regulator of glioblastoma (GBM) an appealing therapeutic target. To document suitability antineoplastic pharmacological target, we investigated how this protein contributed GBM cell reprogramming, property involved in treatment resistance disease recurrence....