A5007435119- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Diabetes and associated disorders
- Nanoparticle-Based Drug Delivery
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Diabetes Management and Research
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Aortic Disease and Treatment Approaches
- Silk-based biomaterials and applications
- Hydrogels: synthesis, properties, applications
- Bone health and osteoporosis research
- Advanced Sensor and Energy Harvesting Materials
- Congenital heart defects research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polymer Surface Interaction Studies
- Cellular Mechanics and Interactions
- Cardiovascular Function and Risk Factors
Ollscoil na Gaillimhe – University of Galway
2016-2025
Trinity College Dublin
2016-2025
Royal College of Surgeons in Ireland
2015-2025
Advanced Materials and BioEngineering Research
2014-2024
Science Foundation Ireland
2019-2024
University Hospital Galway
2023-2024
Regenerative Medicine Institute
2023
Aga Khan University
2016
National Institute for Bioprocessing Research and Training
2010-2015
Georgia Institute of Technology
2009-2010
The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA are combined with collagen yield bioactive, biodegradable (coll-nHA) scaffolds. Their gene-activated matrices for BMP2 demonstrated successful transfection mesenchymal stem cells (MSCs) resulting in high calcium production.
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic osteogenic gene. Stem cell-mediated osteogenesis in vitro, addition to increased vascularization host cells vivo, is enhanced using all systems while the use nanohydroxyapatite vector deliver genes markedly enhances healing.
Bone marrow–derived mesenchymal stem cells (MSCs) have received much attention as a potential treatment for myocardial infarction because of their to integrate into the host myocardium and repair injured heart. The mode action cell–mediated cardiac is still somewhat unclear, including role MSCs in neovascularization. objective this study was determine vitro effect on angiogenesis-related endothelial cell (EC) behavior, migration, monolayer permeability, vessel formation stabilization. In...
Novel block copolymers comprising poly(ethylene glycol) (PEG) and an oligo(tyrosine) were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr(6) undergoes thermoresponsive hydrogelation at a low concentration range of 0.25-3.0 wt % within temperature 25-50 °C. Cryogenic transmission electron microscopy (Cryo-TEM) revealed continuous network fibers throughout the hydrogel sample, even concentrations as 0.25 %. Circular dichroism (CD)...
The increasing prevalence of diabetes, its heterogeneity, and the limited number treatment options drive need for physiologically relevant assay platforms with human genetic background that have potential to improve mechanistic understanding e\xpedite diabetes-related research treatment. In this study, we developed an endocrine pancreas-on-a-chip model based on a tailored microfluidic platform, which enables self-guided trapping single pseudo-islets. Continuous, low-shear perfusion provides...
We have previously examined osteoblast behavior on porous collagen-glycosaminoglycan (CG) scaffolds with a range of mean pore sizes demonstrating superior cell attachment and migration in the largest pores (325 μm). Scaffolds provide framework for construct development; therefore, it is crucial to identify optimal size augmented tissue formation. Utilizing same (85 μm - 325 μm), this study aimed examine effects subsequent differentiation matrix mineralization, understand mechanism by which...
Abstract Bone grafts are the second most transplanted materials worldwide at a global cost to healthcare systems valued over $30 billion every year. The influence of microRNAs in regenerative capacity stem cells offers vast therapeutic potential towards bone grafting; however their efficient delivery target site remains major challenge. This study describes how functionalisation porous collagen-nanohydroxyapatite (nHA) scaffolds with miR-133a inhibiting complexes, delivered using non-viral...
A novel drug delivery system, enabling an in situ, thermally triggered release is described, consisting of injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and assessment vitro bioactivity this formulation detailed. Combining on-demand with situ gelation results a promising candidate for local chemotherapy. As service to our authors readers, journal provides supporting information supplied by the...
The foreign body response is modulated by a dynamic soft reservoir altering the biomechanics of peri-implant tissue.
The foreign body response impedes the function and longevity of implantable drug delivery devices. As a dense fibrotic capsule forms, integration device with host tissue becomes compromised, ultimately resulting in seclusion treatment failure. We present FibroSensing Dynamic Soft Reservoir (FSDSR), an capable monitoring formation overcoming its effects via soft robotic actuations. Occlusion FSDSR porous membrane was monitored over 7 days rodent model using electrochemical impedance...
Fibrosis is a consequence of the pathological remodeling extracellular matrix (ECM) structures in connective tissue an organ. It often caused by chronic inflammation, which over time, progressively leads to excess deposition collagen type I (COL I) that replaces healthy structures, many cases leaving stiff scar. Increasing fibrosis can lead organ failure and death; therefore, developing methods potentially allow real-time monitoring early onset or progression are highly valuable. In this...
Collagen-glycosaminoglycan scaffolds that have been used clinically for skin regeneration also shown significant promise other applications in tissue engineering. However, of thicker tissues with the aid implanted biomaterials is likely to depend on, or be accelerated by, ability establish rapid vascularisation implant. The present study aims a nascent vascular network vitro within CG scaffold as first step towards goal. Mesenchymal stem cells (MSCs) were chosen primary vasculogenic...