A5035842600- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Total Knee Arthroplasty Outcomes
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Orthopedic Infections and Treatments
- Cardiac Structural Anomalies and Repair
- Abdominal Trauma and Injuries
- Corrosion Behavior and Inhibition
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Vascular Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Elasticity and Material Modeling
- 3D Printing in Biomedical Research
- Aortic Disease and Treatment Approaches
- Cellular Mechanics and Interactions
- Cardiac and Coronary Surgery Techniques
- Parkinson's Disease Mechanisms and Treatments
- Dental Implant Techniques and Outcomes
- Aortic aneurysm repair treatments
Trinity College Dublin
2015-2025
Advanced Materials and BioEngineering Research
2014-2023
Royal College of Surgeons in Ireland
2020-2021
Ollscoil na Gaillimhe – University of Galway
1987-2019
National University of Ireland
2006
Arizona Heart Institute
2002
University Hospital Galway
1984
The lack of sensitive objective outcome measures for hand dexterity is a barrier clinical assessment neurological conditions and has negatively affected trials. Here, we clinically validate new method measuring dexterity, novel worn sensor that digitises the Finger Tapping Test. device was assessed in cohort 180 healthy controls 51 people with Amyotrophic Lateral Sclerosis (ALS) compared against rating scales traditional (Nine Hole Peg test grip dynamometry). 14 features were extracted from...
Abstract The long‐term survival of cemented hip replacements depends on the ability fixation to resist fatigue damage. Damage has been assumed accumulate linearly (Miner's law) even though it is unlikely be case in such a porous brittle material. This study addresses nonlinear stress‐dependent nature damage accumulation acrylic bone cement. Specimens were subjected zero‐to‐tension load water at 37°C. A total 15 specimens tested, i.e., five each three stress levels. cyclically loaded certain...
Decellularized arterial scaffolds have achieved success in advancing toward clinical use as vascular grafts. However, concerns remain regarding long-term preservation and sterilization of these scaffolds. Freeze drying offers a means overcoming concerns. In this study, we investigated the effects various freeze-drying protocols on decellularized porcine carotid arteries consequently, determined optimum parameters to fabricate stable, preserved scaffold with unaltered mechanical properties....
Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall restore cardiac function or deliver stem cells in regenerative therapy have shown promising data. However, clinical translation of hydrogel-based therapies has been limited due difficulties injecting them through catheters. We engineered a novel catheter, Advanced Materials Catheter (AMCath), overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid...
Abstract Decellularized arterial scaffolds have achieved success in advancing towards clinical use for small diameter vascular graft applications. Issues remain with effectively cell seeding these scaffolds, which may result slow remodeling vivo and reduced patency rates. This study aims to efficiently bulk load decellularized cells and/or growth factors promote migration within the scaffold. A chitosan/β‐glycerophosphate (β‐GP) hydrogel was used as a delivery vehicle scaffold repopulation...
BackgroundAnimal-derived pericardium is a key material that enables the successful clinical use of bioprosthetic heart valves. Recently, transcatheter valves have placed more emphasis on enhancement this tissue, especially in terms producing uniform, thin, durable tissue. In study, we provide new method to achieve thinner tissue and insights into how consistent which potentially may lead valves.MethodsWe compared four groups tissue: porcine pericardium, bovine pericardium; delaminated serous...
Compression bandaging is the most common therapy used to treat venous ulceration. The bandages must be applied so that they generate a specific pressure profile in order for treatment effective. No method currently exists monitor by bandage over number of days outside laboratory setting. A portable device was developed capable monitoring sub-bandage as user goes about their daily routine. consists four Tekscan FlexiForce A401-series force sensors connected an excitation circuit and PIC...