A5090544371- Amyotrophic Lateral Sclerosis Research
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Motor Control and Adaptation
- Cholinesterase and Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Action Observation and Synchronization
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Blind Source Separation Techniques
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Robotic Locomotion and Control
- Prion Diseases and Protein Misfolding
- Health, Environment, Cognitive Aging
- Intracerebral and Subarachnoid Hemorrhage Research
Trinity College Dublin
2016-2025
Royal College of Surgeons in Ireland
2023-2024
Children's National
2023
University of Strathclyde
2009-2015
Northeastern University
2013-2014
Sharif University of Technology
2008-2011
Central neuropathic pain (CNP) is believed to be accompanied by increased activation of the sensorimotor cortex. Our knowledge this interaction based mainly on functional magnetic resonance imaging studies, but there little direct evidence how these changes manifest in terms dynamic neuronal activity. This study reports presence transient electroencephalography (EEG)-based measures brain activity during motor imagery spinal cord-injured patients with CNP. We analyzed EEG responses imaginary...
Amyotrophic lateral sclerosis (ALS) is a terminal progressive adult-onset neurodegeneration of the motor system. Although originally considered pure degeneration, there increasing evidence disease heterogeneity with varying degrees extra-motor involvement. How combined and nonmotor degeneration occurs in context broader disruption neural communication across brain networks has not been well characterized. Here, we have performed high-density crossectional longitudinal resting-state...
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily affecting motor function, with additional evidence of extensive nonmotor involvement. Despite increasing recognition the as multisystem network disorder characterised by impaired connectivity, precise neuroelectric characteristics cortical communication remain to be fully elucidated. Here, we characterise changes in functional connectivity using beamformer source analysis on resting‐state...
Background Amyotrophic Lateral Sclerosis (ALS) is heterogeneous and overlaps with frontotemporal dementia. Spectral EEG can predict damage in structural functional networks dementia but has never been applied to ALS. Methods 18 incident ALS patients normal cognition 17 age matched controls underwent 128 channel neuropsychology assessment. The data was analyzed using FieldTrip software MATLAB calculate simple connectivity measures scalp network measures. sLORETA used nodal analysis for source...
Abstract Amyotrophic lateral sclerosis is a devastating disease characterized primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% cases. both clinically biologically heterogeneous. Subgrouping currently undertaken using parameters, such as site symptom onset (bulbar or spinal), burden (based on the modified El Escorial Research Criteria) genomics those familial disease. However, exception genomics, these subcategories do not take...
The study of object manipulation has been largely confined to discrete tasks, where accuracy, mechanical effort, or smoothness were examined explain subjects' preferred movements. This investigated a rhythmic task, which involved continuous interaction with nonlinear that led unpredictable behavior. Using simplified virtual version the task carrying cup coffee, we studied how this behavior affected selected strategies. experiment was conducted in set-up, subjects moved ball inside, modeled...
Non-invasive EEG-based Brain-Computer Interfaces (BCI) can be promising for the motor neuro-rehabilitation of paraplegic patients. However, this shall require detailed knowledge abnormalities in EEG signatures The association different subgroups patients and their relation to sensorimotor integration are relevant design, implementation use BCI systems patient populations. This study explores patterns movement related cortical potentials (MRCP) during imagery tasks feet right hand with...
Resting-state electroencephalography (EEG) holds promise for assessing brain networks in amyotrophic lateral sclerosis (ALS). We investigated whether neural β-band oscillations the sensorimotor network could serve as an objective quantitative measure of progressive motor impairment and functional disability ALS patients.
Objective: To evaluate the utility of Mismatch Negativity (MMN), a neurophysiologic marker non-motor cognitive processing, in amyotrophic lateral sclerosis (ALS). Methods: 89 patients, stratified into 4 different phenotypic presentations Amyotrophic Lateral Sclerosis (67 spinal-onset, 15 bulbar-onset, 7 ALS-FTD, C9ORF72 gene careers), and 19 matched controls underwent 128-channel EEG data recording. Subjects were presented with standard auditory tones interleaved pitch-deviant 3 recording...
To localise and characterise changes in cognitive networks Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. The MMN waveform has an increased average delay ALS. been attributed to change detection involuntary attention switching. This therefore indicates pathological impairment the neural network components which generate these functions. Source localisation can mitigate poor spatial resolution sensor-level EEG by associating signals...
Abstract Recent electroencephalography (EEG) studies have shown that patterns of brain activity can be used to differentiate amyotrophic lateral sclerosis (ALS) and control groups. These differences interrogated by examining EEG microstates, which are distinct, reoccurring topographies the scalp's electrical potentials. Quantifying temporal properties four canonical microstates elucidate how dynamics functional networks altered in neurological conditions. Here we analysed detect quantify...
To establish if induced current direction across the motor cortex alters sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker. Threshold tracking-TMS was undertaken in 35 people with and 39 controls. Using a coil orientation which induces posterior-anterior (PA)-directed cortex, SICI (1ms 3ms interstimulus intervals) facilitation (ICF, 10ms interval) were recorded. SICI3ms also recorded using anterior-posterior...
The lack of sensitive objective outcome measures for hand dexterity is a barrier clinical assessment neurological conditions and has negatively affected trials. Here, we clinically validate new method measuring dexterity, novel worn sensor that digitises the Finger Tapping Test. device was assessed in cohort 180 healthy controls 51 people with Amyotrophic Lateral Sclerosis (ALS) compared against rating scales traditional (Nine Hole Peg test grip dynamometry). 14 features were extracted from...
The aim of this study was to test how the presence central neuropathic pain (CNP) influences performance a motor imagery based Brain Computer Interface (BCI). In electroencephalography (EEG) study, we tested BCI classification accuracy and analysed event related desynchronisation (ERD) in 3 groups volunteers during imagined movements their arms legs. comprised nine able-bodied people, ten paraplegic patients with CNP (lower abdomen legs) without CNP. We two types classifiers: channel bipolar...
Abstract Treadmill training (TT) has been extensively used as an intervention to improve gait and mobility in patients with Parkinson’s disease (PD). Regional global effects on brain activity could be induced through TT. Training can lead a beneficial shift of interregional connectivity towards physiological range. The current work investigates the TT during walking at rest by using both functional near-infrared spectroscopy magnetic resonance imaging. Nineteen PD (74.0 ± 6.59 years, 13...
The human motor system is organized for execution of various tasks in a different and flexible manner. kinetic redundancy the musculoskeletal significant property by which central nervous achieves many complementary goals. An equilibrium-based biomechanical model isometric three-dimensional exertions trunk muscles has been developed. Following definition role uncontrolled manifold, concept explored mathematical terms. null space kinetically redundant when certain joint moment and/or...
Coherence is a mathematical measure of correlation in the frequency domain, commonly used to quantify oscillatory synchrony bio-signals such as electroencephalogram (EEG). In biomedical applications, assessment functional connectivity, reliable estimation coherence paramount importance for studying function complex brain networks, well their disruption neurological disorders. A major challenge robust measures presence artefacts. Here, we propose an alternative method finding by estimating...
We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an electrophysiological index of attention switching. measured MMN 128-channel EEG longitudinally (2-5 timepoints) 60 ALS patients and cross-sectionally 62 healthy controls. Using dipole fitting linearly constrained minimum variance beamforming we investigated cortical source activity changes over time. In ALS, inferior...
Objective.To characterize the cortical oscillations associated with performance of sustained attention to response task (SART) and their disruptions in neurodegenerative condition amyotrophic lateral sclerosis (ALS).Approach.A randomised SART was undertaken by 24 ALS patients 33 healthy controls during 128-channel electroencephalography (EEG). Complex Morlet wavelet transform used quantify non-phase-locked oscillatory activity event-related spectral perturbations performing SART. We...
The execution of voluntary movements is primarily governed by the cerebral hemisphere contralateral to moving limb. Previous research indicates that ipsilateral motor network, comprising primary cortex (M1), supplementary area (SMA), and premotor (PM), plays a crucial role in planning limb movements. However, precise functions this network its interplay different task contexts have yet be fully understood. Twenty healthy right-handed participants (10 females, mean age 26.1 ± 4.6 years)...
To identify cortical regions engaged during the sustained attention to response task (SART) and characterize changes in their activity associated with neurodegenerative condition amyotrophic lateral sclerosis (ALS).High-density electroencephalography (EEG) was recorded from 33 controls 23 ALS patients a SART paradigm. Differences event-related potential peaks were measured for Go NoGo trials. Sources active these localized, ALS-associated differences quantified.Go N2 P3 peak sources...
Abstract Primary lateral sclerosis (PLS) is a slowly progressing disorder, which characterized primarily by the degeneration of upper motor neurons (UMNs) in primary area (M1). It not yet clear how function sensorimotor networks beyond M1 are affected PLS. The aim this study was to use cortico-muscular coherence (CMC) characterize oscillatory drives between cortical regions and muscles during task PLS examine relationship CMC level clinical impairment. We recorded EEG EMG from hand 16...