Patrick Beauchesne
A5090901098- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Forensic Anthropology and Bioarchaeology Studies
- Neuroblastoma Research and Treatments
- Paleopathology and ancient diseases
- Medical Imaging Techniques and Applications
- Ocular Oncology and Treatments
- Nanoplatforms for cancer theranostics
- Neurofibromatosis and Schwannoma Cases
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Medicine and Dermatology Studies History
- History of Medicine Studies
- Drug Transport and Resistance Mechanisms
- Fire effects on ecosystems
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Medical Imaging and Pathology Studies
- Ecology and Vegetation Dynamics Studies
- Lung Cancer Research Studies
- Hydrology and Sediment Transport Processes
- Forest Management and Policy
University of Michigan–Dearborn
2017-2023
University of California, Berkeley
2011-2020
Centre Hospitalier Régional et Universitaire de Nancy
2010-2019
Institut du Cerveau
2011-2018
Institut de Neurophysiopathologie
2018
Inserm
2003-2011
Western University
2006-2011
Assistance Publique – Hôpitaux de Paris
2011
Centre National pour la Recherche Scientifique et Technique (CNRST)
2011
Sorbonne Université
2011
The management of glioblastoma multiforme (GBM) in elderly patients with poor performance status is not well established. A trial evaluating the efficacy and safety temozolomide alone this population was undertaken.Patients age 70 years or older newly diagnosed GBM postoperative Karnofsky score (KPS) less than were eligible for nonrandomized phase II trial. Treatment consisted 150 to 200 mg/m(2)/d 5 days every 4 weeks until disease progression. Radiotherapy administered. primary end point...
Riparian forest strips are usually protected from logging for their buffer effect on aquatic habitats. However, value to terrestrial wildlife is unknown. From 1989 1992, we compared bird abundance and species composition in 5 experimental riparian (20-m, 40-m, 60-m, control [>300 m wide], intact strips, 20-m-wide thinned strips), boreal balsam fir (Abies balsamea) stands, 3 years following clear-cutting. Bird densities increased 30-70% (P 0.05) thereafter approximately pretreatment levels....
Malignant gliomas account for approximately 60% of all primary brain tumors in adults. Prognosis these patients has not significantly changed recent years-despite debulking surgery, radiotherapy and cytotoxic chemotherapy-with a median survival 9-12 months. Virtually no are cured their illness. usually locally invasive tumors, though extra-neural metastases can sometimes occur late the course disease (median two years). They generally appear after craniotomy although spontaneous have also...
Abstract Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups currently distinguished on the basis IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis transcriptome, genome methylome 156 OT. Not only does our multi-omics classification match current but also reveals three within co-deleted tumours, associated with specific expression patterns nervous system cell types: oligodendrocyte, oligodendrocyte precursor (OPC) neuronal...
The aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs). 50 AO patients enrolled the French national network for high-grade oligodendroglial tumors were analyzed. genomic profiles IDH mutational statuses assessed using high-resolution single-nucleotide polymorphism arrays direct sequencing, respectively. gene expression 25 1p/19q-codeleted AOs studied on Affymetrix arrays. Most cases frontal lobe contrast-enhanced (52%), but...
We assessed the efficacy and safety of bevacizumab (BEV) through multiple lines in patients with recurrent glioblastoma who had progressed after first-line treatment radiotherapy, temozolomide, BEV. TAMIGA (NCT01860638) was a phase II, randomized, double-blind, placebo-controlled, multicenter trial adult glioblastoma. Following surgery, newly diagnosed received consisting radiotherapy plus temozolomide BEV, followed by six cycles then BEV monotherapy until disease progression (PD1)....
The aim of this study was to correlate histological features and molecular characteristics in anaplastic oligodendrogliomas (AOs). 203 AO patients, enrolled the French national network POLA, were analyzed. genomic profiles 191 cases studied using arrays. IDH mutational status assessed by immunohistochemistry direct sequencing. 1p/19q codeletion present 79% associated with alpha-internexin expression (P < 10−4), IDH1/2 mutation chromosome 4 loss 10−3), better overall survival 10−4). Based on...
OBJECTIVE The goal of this study was to provide insight into the influence gliomas on gestational outcomes, impact pregnancy gliomas, and identification patients at risk. METHODS In multiinstitutional retrospective study, authors identified 52 pregnancies in 50 women diagnosed with a glioma. RESULTS For known prior (n = 24), we found following: 1) An increase quantified imaging growth rates occurred during 87% cases. 2) Clinical deterioration 38% cases, seizures alone resolving after...
Anaplastic oligodendroglioma (AO) are rare primary brain tumours that generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC FUBP1. We also identified recurrent TCF12 additional series of 83 AO. Overall, 7.5% mutated for TCF12, which encodes oligodendrocyte-related...
We aimed to study the potential clinical relevance of 9p allelic loss, with or without copy number variation, in 1p/19q codeleted anaplastic oligodendroglial tumors (AOTs).This enrolled 216 patients AOT. The prognostic value loss was investigated using a French nation-wide prospective registry, POLA (prise en charge des tumeurs oligodendrogliales anaplasiques) and high-density single nucleotide polymorphism arrays. validated our results Repository Molecular Brain Neoplasia Data (REMBRANDT)...
Abstract Lessons Learned Results suggest that the combination of bevacizumab plus temozolomide is active in terms response rate, survival, performance, quality life, and cognition elderly patients with glioblastoma multiforme poor performance status. Whether this superior to alone remains be demonstrated by a randomized study. Background The optimal treatment (GBM) aged ≥70 years Karnofsky status (KPS) &lt;70 not established. This clinical trial evaluated efficacy safety upfront (TMZ)...
Ultrafractionation of radiation therapy is a novel regimen consisting irradiating tumors several times daily, delivering low doses (<0.75 Gy) at which hyperradiosensitivity occurs. We recently demonstrated the high efficiency ultrafractionated radiotherapy (RT) on glioma xenografts and report here phase II clinical trial to determine safety, tolerability, efficacy an ultrafractionation in patients with newly inoperable glioblastoma (GBM). Thirty-one histologically proven, diagnosed,...
✓ The authors report on a case of right temporal glioblastoma multiforme (GBM) that metastasized to multiple bone regions (dorsolumbar vertebrae and iliac bone) 8 months after initial diagnosis, despite combined radio- chemotherapy. Results whole-bone single-photon emission computerized tomography (SPECT) study using the imaging agent Sestamibi (MIBI) revealed extracranial metastases from GBM. A magnetic resonance dorsolumbar spinal region completed radiological investigation. Cells...
Malignant gliomas display aggressive local behavior and are not cured by existing therapy. Some cell lines that considered radioresistant respond to low radiation doses (<1 Gy) with increased killing (low-dose hypersensitivity). In our study, 4 of 5 human glioma exhibited significant X-ray sensitivity at below 1 Gy. The surviving fractions (SFs) obtained 0.7 and/or 0.8 Gy were comparable those 1.5 Low-dose hypersensitivity was evident when irradiation combined etoposide treatment. Repeated...
This article explores age- and sex-related patterns of cortical bone loss, assessed by radiogrammetry the second metacarpal, from a skeletal sample excavated Imperial Roman port city Velia (1st 2nd century ad), to contribute our understanding health disease during period. Patterns loss at are also compared with other historical samples modern clinical data. It was hypothesised that in this well-represented (n = 71) would mirror those reported populations. Differences quantity between three...
Anaplastic oligodendrogliomas (AOD) are rare glial tumors in adults with relative homogeneous clinical, radiological and histological features at the time of diagnosis but dramatically various clinical courses. Studies have identified several molecular abnormalities or biological relevance to AOD (e.g. t(1;19)(q10;p10), IDH1, IDH2, CIC FUBP1 mutations).To better characterize behavior this tumor type, creation a national multicentric network, named "Prise en charge des OLigodendrogliomes...
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