A5079137532- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- HIV Research and Treatment
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Agriculture and Rural Development Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Education, sociology, and vocational training
- Latin American Cultural Politics
- Neurofibromatosis and Schwannoma Cases
- Monoclonal and Polyclonal Antibodies Research
- Science Education and Pedagogy
- French Language Learning Methods
- Neuroscience and Neural Engineering
- Urological Disorders and Treatments
- RNA Interference and Gene Delivery
- French Urban and Social Studies
- Ureteral procedures and complications
- Chemokine receptors and signaling
- Urinary and Genital Oncology Studies
Université d'Évry Val-d'Essonne
2021-2025
L’Institut du Cancer Courlancy Reims
2013-2024
Université Paris-Saclay
2020-2024
Laboratoire Francis Perrin
2024
Servier (France)
2024
Cégep de Lévis
2024
Peuplements végétaux et bioagresseurs en milieu tropical
2024
Hospices Civils de Lyon
2024
Inserm
1999-2023
Université de Toulouse
2021-2023
In metastatic colorectal cancer, phase III studies have demonstrated the superiority of fluorouracil (FU) with leucovorin (LV) in combination irinotecan or oxaliplatin over FU + LV alone. This study investigated two sequences: folinic acid, FU, and (FOLFIRI) followed by (FOLFOX6; arm A), FOLFOX6 FOLFIRI (arm B).
There is no community standard for the treatment of glioblastoma in patients 70 years age or older. We conducted a randomized trial that compared radiotherapy and supportive care with alone such patients.Patients older newly diagnosed anaplastic astrocytoma Karnofsky performance score higher were randomly assigned to receive only plus (focal radiation daily fractions 1.8 Gy given 5 days per week, total dose 50 Gy). The primary end point was overall survival; secondary points progression-free...
The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because actual amount has seldom been assessed.Cases GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 prospectively 1996. Inclusion criteria patient age ≥ 18 years at diagnosis, histological diagnosis GIIG, MRI...
Purpose This study compared chemotherapy discontinuation with maintenance therapy leucovorin and fluorouracil after six cycles of folinic acid, fluorouracil, oxaliplatin (FOLFOX) in the first-line treatment metastatic colorectal cancer. Patients Methods Two hundred two patients untreated cancer were randomly assigned to receive modified FOLFOX7 (mFOLFOX7) followed by simplified plus bolus infusional until progression (arm 1 or arm, n = 98) mFOLFOX7 before a complete stop 2 chemotherapy-free...
Real-life studies on patients with primary CNS lymphoma (PCNSL) are scarce. Our objective was to analyze, in a nationwide population-based study, the current medical practice management of PCNSL.The French oculo-cerebral network (LOC) database prospectively records all newly diagnosed PCNSL cases from 32 centers. Data between 2011 and 2016 were retrospectively analyzed.We identified 1,002 immunocompetent (43% aged >70 years, median Karnofsky Performance Status [KPS] 60). First-line treatment...
In metastatic colorectal cancer, phase III studies have demonstrated the superiority of fluorouracil (FU) with leucovorin (LV) in combination irinotecan or oxaliplatin over FU + LV alone. This study investigated two sequences: folinic acid, FU, and (FOLFIRI) followed by (FOLFOX6; arm A), FOLFOX6 FOLFIRI (arm B).
Treatment of relapsed/refractory (R/R) primary CNS lymphoma (PCNSL) is poorly defined, because randomized trials and large studies are lacking. The aim this study was to analyze the characteristics, management, outcome R/R PCNSL patients after first-line therapy in a nationwide cohort.We analyzed following treatment who had been prospectively registered database French network for oculocerebral (LOC) between 2011 2014.Among 563 treated with therapy, we identified 256 relapsed (n = 93, 16.5%)...
This randomized, 2 x factorial study compared a semimonthly (LVFU2) with monthly (FULV) regimen of fluorouracil and leucovorin 24 versus 36 weeks each as adjuvant treatment patients stage II (Dukes' B2) III C) colon cancer.LVFU2 was administered semi-monthly for consecutive days dl- or l-leucovorin (200 100 mg/m2, respectively) 2-hour infusion, followed by 400 mg/m2 FU bolus 600 22-hour continuous infusion. FULV 5 15-minute infusion l-leucovorin, infusion.A total 905 were randomly assigned....
Supratentorial diffuse low-grade gliomas present a slow macroscopic tumor growth that can be quantified through the measurement of their velocity diametric expansion. We assessed whether spontaneous expansion predict long-term outcomes as categorical variable and continuous predictor.A total 407 adult patients with newly diagnosed supratentorial in adults were studied.The mean before first-line treatment was 5.8 ± 6.3 mm/year. During follow-up (mean, 86.5 59.4 months), 209 presented...
DIRECT intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding β-galactosidase. To explore the potential of for therapy neurological disease we constructed a tyrosine hydroxylase, and optimized injection express in striatum unilaterally denervated rats. These animals have dopamine depletion their lesioned striatum, causing rotation asymmetry induced by apomorphine. One, two weeks after this sensorimotor was decreased not control Histological...
The goal of this experiment was to determine the electrical properties tissue reaction implanted microelectrode arrays. We describe a new method analyzing impedance spectroscopy data complex as function postimplantation time. A model is used extract parameters electrode-tissue interface, and isolate immediately surrounding microelectrode. arrays consist microfabricated polyimide probes, incorporating four 50- mum-diameter platinum microelectrodes. devices were in primary motor cortex adult...
Abstract BACKGROUND: O 6 ‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation status was proposed as a prognostic biomarker for patients with glioblastoma. However, the impact of MGMT in newly diagnosed glioblastoma who receive carmustine‐releasing wafers (Gliadel) along temozolomide (TMZ) is still unknown. METHODS: and protein expression were analyzed formalin‐fixed, paraffin‐embedded tumor specimens obtained from 111 French Patients received Gliadel followed by radiotherapy...
Abstract Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups currently distinguished on the basis IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis transcriptome, genome methylome 156 OT. Not only does our multi-omics classification match current but also reveals three within co-deleted tumours, associated with specific expression patterns nervous system cell types: oligodendrocyte, oligodendrocyte precursor (OPC) neuronal...
This paper focuses on difficulties students have in reading images, regarding the understanding of a particular domain, e.g. optics and colour. We concentrated upon what extent teachers were conscious such they suggested doing to avoid possible pitfalls this respect. A list expected obstacles, set up initiate study, was shown be appropriate. It shows that, when predicted or observed misunderstanding, consulted tended add some elements misleading image rather than discussing symbols that...
Abstract BACKGROUND. Patients older than 75 years of age are usually excluded from metastatic colorectal cancer randomized studies. The OPTIMOX1 study evaluated FOLFOX7, a simplified (s) leucovorin (LV) and 5‐fluorouracil (5FU) regimen (sLV5FU2) with high‐dose oxaliplatin, in new oxaliplatin stop‐and‐go strategy. An exploratory cohort patients aged 76 to 80 was included the study. METHODS. In all, 620 previously untreated were between FOLFOX4 until progression (arm A), or FOLFOX7 for 6...
CC chemokine receptor 5 (CCR5) is a for chemokines and the coreceptor R5 HIV-1 entry into CD4(+) T lymphocytes. Chemokines exert anti-HIV-1 activity in vitro, both by displacing viral envelope glycoprotein gp120 from binding to CCR5 promoting endocytosis, suggesting that they play protective role HIV infection. However, we showed here different conformations at cell surface are differentially engaged gp120, making weaker inhibitors of infection than would be expected their affinity constants...