A5073727976- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Neuroblastoma Research and Treatments
- Brain Tumor Detection and Classification
- Vascular Malformations Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Melanoma and MAPK Pathways
- Neuroscience and Neuropharmacology Research
- Neurological Complications and Syndromes
- Metabolomics and Mass Spectrometry Studies
- Head and Neck Surgical Oncology
- Drug Transport and Resistance Mechanisms
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
Sorbonne Université
2019-2025
Pitié-Salpêtrière Hospital
2021-2025
Assistance Publique – Hôpitaux de Paris
2019-2025
Inserm
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Institut du Cerveau
2019-2025
Allen Institute for Brain Science
2024-2025
NeurON : Interface Neuro-machine
2024
University of Modena and Reggio Emilia
2019-2024
Hôpitaux Universitaires Paris-Ouest
2023-2024
Primary central nervous system lymphoma (PCNSL) is a rare and distinct entity within diffuse large B-cell presenting with variable response rates probably to underlying molecular heterogeneity.To identify characterize PCNSL heterogeneity facilitate clinical translation, we carried out comprehensive multi-omic analysis [whole-exome sequencing, RNA sequencing (RNA-seq), methylation features] in discovery cohort of 147 fresh-frozen (FF) immunocompetent PCNSLs validation formalin-fixed,...
OBJECTIVE There is a lack of data regarding the benefit-risk ratio and therapeutic value brain biopsy in very elderly patients with tumors. This study aimed to evaluate safety stereotactic aged ≥ 80 years assess impact procedure on subsequent management overall survival (OS). METHODS The authors retrospectively analyzed medical records all who underwent for newly diagnosed intracerebral tumor during 15-year period at single institution. RESULTS During period, 2350 biopsies were performed,...
BackgroundGlioblastoma (GBM) is the most common devastating primary brain cancer in adults. In our clinical practice, median overall survival (mOS) of GBM patients seems increasing over time.MethodsTo address this observation, we have retrospectively analyzed prognosis 722 newly diagnosed patients, aged below 70, good conditions (i.e. Karnofsky Performance Status –KPS- above 70%) and treated department according to standard care (SOC) between 2005 2018. Patients were divided into two groups...
Primary central nervous system lymphoma (PCNSL) treatment relies on a high-dose methotrexate based chemotherapy (HD-MTX-based CT) regimen; however, whether there is specific microbiota composition association with response and clinical outcomes remains incompletely understood. We conducted prospective study of PCNSL patients, included in the trial NCT02313389 ancillary NCT04253496 from 2020 to 2023, where patients were treated first line HD-MTX-based polychemotherapy without consolidation...
Background: Differentiating brain radionecrosis (RN) from tumor progression (TP) is a persistent clinical difficulty. Here, we compared the diagnostic accuracy of leakage-corrected relative cerebral blood volume (rCBV) and fluid-suppressed amide proton transfer-weighted (APTw) imaging in distinguishing between RN TP metastases. Methods: Subjects with enlarging lesions after stereotactic radiosurgery were prospectively examined at 3T. APTw data acquired 3D snapshot-gradient echo sequence. B0...
The optimal consolidation strategy for primary central nervous system lymphoma (PCNSL) remains controversial. Preventing radio-induced neurotoxicity of treatment through reduced-dose whole-brain radiotherapy (rdWBRT) at a dose 23.4 Gy is an interesting alternative to conventional WBRT in patients aged <60 years. From the LOC Network (Network Oculo-cerebral Lymphomas) database, we retrospectively selected with PCNSL years who showed complete (CR) or unconfirmed CR after high-dose...
D-2-hydroxyglutarate (2HG) characterizes
Abstract A novel methylation class, “neuroepithelial tumor, with PLAGL1 fusion” (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor recurrent histopathological features suggesting an ependymal differentiation . Because of the recent identification this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present detailed series nine cases -fused tumors, reclassified from ependymomas,...
Background Noninvasive identification of glioma subtypes is important for optimizing treatment strategies. Purpose To compare the in vivo neurochemical profiles between isocitrate dehydrogenase (IDH) 1–mutant 1p/19q codeleted gliomas and their noncodeleted counterparts measured by MR spectroscopy at 3.0 T with a point-resolved (PRESS) sequence optimized D-2-hydroxyglutarate (2HG) detection. Materials Methods Adults IDH1-mutant were retrospectively included this study from two university...
Abstract Purpose Amide proton transfer‐weighted (APTw) MRI at 3T provides a unique contrast for brain tumor imaging. However, APTw imaging suffers from hyperintensities in liquid compartments such as cystic or necrotic structures and distorted signal intensity. Recently, it has been shown that heuristically motivated fluid suppression can remove artifacts significantly improve the readability of Theory Methods In this work, we show actually be understood by known concept spillover dilution,...
PURPOSE Patients with IDH-mutant 1p/19q-codeleted grade 3 oligodendroglioma (O3 IDHmt/Codel ) benefit from adding alkylating agent chemotherapy to radiotherapy (RT). However, the optimal regimen between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vincristine (PCV) temozolomide (TMZ) remains unclear given lack of randomized trial data comparing both regimens. METHODS The objective was assess overall survival (OS) progression-free (PFS) associated first-line PCV/RT...
Craniopharyngioma (CP) in adults is a rare benign tumor associated with many morbidities, limited contemporary studies to define treatment, and follow-up guidelines.A single-center retrospective study was conducted on patients aged ≥ 18 years from 2006-2018 CP who were treated proton therapy (PT). Late toxicity defined as minimum of months diagnosis. Overall survival (OS), local recurrence-free (LRFS), characterized using Kaplan-Meier Cox regression analyses.Ninety-one met the criteria,...
Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during period active maturation the human brain. Whereas adaptive mechanisms seem take place in POMS brain short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at significantly younger age than adult-onset MS (AOMS) patients. We tested for first time whether significant alterations already occurred their early...
Despite a high response rate at the first evaluation during induction chemotherapy, risk of early relapse remains and unpredictable in primary CNS lymphomas (PCSNLs). We aimed to assess prognostic value IL-10 levels CSF (e-IL-10) after 2 months chemotherapy.
Epilepsy is a common comorbidity of brain tumors; however, little known about the prevalence, onset time, semiology, and risk factors seizures in primary CNS lymphoma (PCNSL). Our objectives were to determine prevalence epilepsy PCNSL, identify associated with epilepsy, investigate prognostic significance PCNSL.