A5063384332- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Trace Elements in Health
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Heavy Metal Exposure and Toxicity
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Intensive Care Unit Cognitive Disorders
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Fetal and Pediatric Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Schizophrenia research and treatment
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Diet and metabolism studies
Sorbonne Université
2017-2025
Pitié-Salpêtrière Hospital
2017-2025
Assistance Publique – Hôpitaux de Paris
2018-2025
Institut du Cerveau
2017-2025
Inserm
2017-2024
Centre National de la Recherche Scientifique
2017-2024
Hôpital Charles-Foix
2017-2022
Institut de Psychiatrie et Neurosciences de Paris
2021-2022
Gènes, synapses et cognition
2022
University of Chieti-Pescara
2006-2021
Background The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports idea that beside classic hallmarks disease, namely accumulation amyloid-β (Aβ) and neurofibrillary tangles, other factors significantly contribute initiation progression disease. Among them, mitochondria failure, an unbalanced neuronal redox state, dyshomeostasis endogenous metals like copper, iron, zinc have all been...
Altered neuronal excitability is emerging as an important feature in Alzheimer's disease (AD). Kv2.1 potassium channels are modulators of and synaptic activity. We investigated currents its relation to the intrinsic activity hippocampal neurons from 3xTg-AD (triple transgenic mouse model disease) mice, a widely employed preclinical AD model. Synaptic was also by analyzing spontaneous [Ca(2+)]i spikes. Compared with wild-type (Non-Tg (non-transgenic model)) cultures, showed enhanced spike...
Background Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of aging brain. In this study, we evaluated effects set structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness group healthy elderly individuals. CT lasted six months. Methodology Neuropsychological occupational performances were before at end training period. fMRI was...
<h3>Importance</h3> There is evidence of central nervous system impairments associated with coronavirus disease 2019 (COVID-19) infection, including encephalopathy. Multimodal monitoring patients COVID-19 may delineate the specific features COVID-19–related encephalopathy and guide clinical management. <h3>Objectives</h3> To investigate clinical, biological, brain magnetic resonance imaging (MRI) findings in association electroencephalographic (EEG) for COVID-19, to better refine <h3>Design,...
Epilepsy surgery, particularly for temporal lobe epilepsy (TLE), remains a vital treatment option patients with drug-resistant seizures. However, accurately predicting surgical outcomes significant challenge. This study introduces novel biomarker derived from brain connectivity changes caused by TLE analyzed using hyperbolic graph embeddings, to predict success. Using structural and diffusion magnetic resonance imaging (MRI) data 51 patients, we examined differences in networks associated...
Abstract Zinc (Zn 2+ ) is a pleiotropic modulator of the neuronal and brain activity. The disruption intraneuronal Zn levels triggers neurotoxic processes affects functioning. In this study, we investigated how pharmacological modulation synaptic plasticity cognition in wild-type mice. To manipulate levels, employed (and copper) chelator 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ). CQ was administered for two weeks to 2.5-month-old (m.o.) mice, effects studied on BDNF-related...
Purpose: The temporal lobe, a critical hub for cognition, also plays central role in the regulation of autonomic cardiovascular functions. Lesions this area are usually associated with abnormalities heart rate (HR) and blood pressure (BP). analysis variability (HRV) is useful to evaluate cardiac parasympathetic nervous system activity. This study aims at comparing HRV changes occurring two groups patients suffering from Temporal Lobe Epilepsy (TLE). To that aim, we evaluated differentiated...
Human neuronal activity, recorded in vivo from microelectrodes, may offer valuable insights into physiological mechanisms underlying human cognition and pathophysiological of brain diseases, particular epilepsy. Continuous long-term recordings are necessary to monitor non predictable pathological activities like seizures or sleep. Because their high impedance, microelectrodes more sensitive noise than macroelectrodes. Low levels crucial detect action potentials background noise, further...
Focal seizures are assumed to arise from a hypersynchronous activity affecting circumscribed brain region. Using microelectrodes in seizure-generating deep mesial regions of 9 patients, we investigated the firing hundreds single neurons before, during, and after ictal electroencephalogram (EEG) discharges. Neuronal spiking at seizure initiation was highly heterogeneous not hypersynchronous. Furthermore, groups showed significant changes minutes before with no concomitant corresponding...
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is major importance. Changes brain cholesterol homeostasis an emerging candidate for excitotoxicity. We conducted overall analysis both (i) in fluids and tissues from patients SE: blood (n = 63, n 87 controls), CSF 32, 60 post-mortem 8, 8 controls) (ii) mouse model SE induced by intrahippocampal injection kainic acid. 24-hydroxycholesterol levels were decreased acid hippocampus human plasma when...
Metal dyshomeostasis plays a crucial role in promoting several neurodegenerative diseases including Alzheimer's disease (AD), condition that has been linked to deregulation of brain levels Al, Fe, Mn, Cu, and Zn. Thus, quantitative multi-element profiling tissues from AD models can be great value assessing the pathogenic metals as well therapeutic interventions aimed at restoring metal homeostasis brain. In this study, we employed low resolution inductively coupled plasma mass spectrometry...
<h3>Background and purpose</h3> Dementia with Lewy bodies (DLB) is characterised by neuroleptic hypersensitivity. It unclear, however, whether the hypersensitivity implies an increased incidence of malignant syndrome (NMS) or akinetic crisis (AC), which are expressions same possibly lethal clinical event, AC in DLB can appear independently treatment. In our prospective study, we assessed a cohort as compared that patients Parkinson disease (PD). <h3>Methods</h3> total, 614 PD 236 were...
Abstract Volitional respiratory manoeuvres such as sniffing and apnoea play a key role in the active olfactory exploration of environment. Their impairment by neurodegenerative processes could thus impair abilities with ensuing impact on quality life. Functional brain imaging studies have identified networks engaged voluntary apnoea, comprising primary motor somatosensory cortices, insula, anterior cingulate cortex amygdala. The temporal organization oscillatory activities these are not...