A5075973044- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Medical Image Segmentation Techniques
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- Neural and Behavioral Psychology Studies
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Advanced Radiotherapy Techniques
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Neuroscience and Neural Engineering
- Image Retrieval and Classification Techniques
- Sleep and Wakefulness Research
Pitié-Salpêtrière Hospital
2012-2023
Sorbonne Université
2012-2023
Institut du Cerveau
2010-2023
Assistance Publique – Hôpitaux de Paris
2009-2023
Centre National de la Recherche Scientifique
2007-2023
Inserm
2008-2023
Université Paris Cité
1998-2019
Allen Institute for Brain Science
2019
Hôpital Charles-Foix
2017
Institut national de recherche en informatique et en automatique
2014-2015
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious masked was observed multiple cortical areas, mostly within an early time window (<300 ms), accompanied by induced gamma-band activity, but without coherent long-distance neural suggesting quickly dissipating feedforward wave. In contrast, unmasked characterized the convergence four distinct...
Interictal high-frequency oscillations over 200 Hz have been recorded with microelectrodes in the seizure onset zone of epileptic patients suffering from mesial temporal lobe epilepsy. Recent work suggests that similar can be detected using standard diagnostic macroelectrodes. However, only a few channels were examined these studies, so little information is available on spatial extent oscillations. Here, we present data larger number intracerebral contacts (mean 38) 16 patients. Data...
A classical but still open issue in cognitive psychology concerns the depth of subliminal processing. Can meaning undetected words be accessed absence consciousness? Subliminal priming experiments normal subjects have revealed only small effects whose interpretation remains controversial. Here, we provide a direct demonstration semantic access for unseen masked words. In three epileptic patients with intracranial electrodes, recorded brain potentials from amygdala, neural structure that...
To define the prognostic factors for local control and overall survival among 100 consecutive patients with chordoma of base skull or upper cervical spine treated by fractionated irradiation combining proton photon beams. Between December 1993 August 2002, (median age: 53 years [8 - 85], M/F sex ratio: 3/2) were a combination high-energy photons protons. The component was delivered at Centre de Protonthérapie d'Orsay (CPO) 201 MeV beam. median total dose to tumor volume 67 GyECo. With...
Auditory novelty detection has been associated with different cognitive processes. Bekinschtein et al. (2009) developed an experimental paradigm to dissociate these processes, using local and global novelty, which were associated, respectively, automatic versus strategic perceptual processing. They have mostly studied event-related potentials (ERPs), but spiking activity as indexed by gamma (60–120 Hz) power interactions between brain regions modulations in beta-band (13–25 functional...
The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably right anterior insula (rAI). However, studies on consistently showed involvement midline default network (DN) nodes, without referring visceral monitoring. Here, we investigate this apparent discrepancy. We previously that responses heartbeats DN encode two different self-dimensions, agentive 'I' introspective 'Me', a whole-brain analysis...
Left medial temporal lobe epilepsy (MTLE) is associated with verbal memory impairment usually related to hippocampal damage. We used functional MRI (fMRI) investigate the patterns of activity in healthy volunteers and MTLE patients engaged episodic tasks look for evidence a reallocation epileptic patients. fMRI data were collected from seven left-sided sclerosis 10 right-handed control subjects on 3T scanner. Subjects instructed learn list 17 words (encoding) then recall them (retrieval)...
Abstract Developmental disorders of the hippocampal formation (HF) have been described in epileptic syndromes associated with lissencephaly, but HF malformations can be found without widespread cortical changes. We report 19 patients partial epilepsy and abonormal patterns on magnetic resonance imaging (MRI). The changes consisted incomplete folding abnormal medial location along choroid fissure, globular shape and/or verticalization, were observed following three contexts: (1) diffuse...
This paper studies gamma-band responses from two implanted epileptic patients during a simple visual discrimination task. Our main aim was to ascertain, in reliable manner, whether evoked (stimulus-locked) and induced (triggered by, but not locked to, stimuli) are present intracranial recordings. For this purpose, we introduce new methods adapted detect the presence of gamma at level recording, intermediary between EEG-scalp unicellular responses. The analysis relies on trial-by-trial...
The mechanism of interictal glucose hypometabolism remains unclear, but this abnormality occurs more frequently in temporal lobe epilepsy (TLE) than other types partial epilepsy. Therefore has been suggested to reflect mesial sclerosis (MTS). To investigate this, we selected 22 patients with refractory origin (MTLE) who had hippocampal atrophy based on magnetic resonance imaging (MRI) volumetric analysis. We then analyzed the metabolic correlates unilateral atrophy. Thirteen regions interest...
This study examined the contribution of medial temporal lobe (MTL) structures in autobiographical memory. While some investigators have reported a gradient memory performance, characterized by retrieval difficulties limited to recent periods life [Squire and Alvarez (Retrograde amnesia consolidation: neurobiological perspective. Curr Opin Neurobiol 1995; 5: 169–77)], others suggested that this impairment involves all life-time [Nadel Moscovitch (Memory consolidation, retrograde hippocampal...
Neocortical local field potentials have shown that gamma oscillations occur spontaneously during slow-wave sleep (SWS). At the macroscopic EEG level in human brain, no evidences were reported so far. In this study, by using simultaneous scalp and intracranial recordings 20 epileptic subjects, we examined cerebral cortex SWS. We report low (30–50 Hz) high (60–120 frequency bands recurrently emerged all investigated regions their amplitudes coincided with specific phases of cortical slow wave....
In Alzheimer's disease (AD), the hippocampus is an early site of tau pathology and neurodegeneration. Histological studies have shown that lesions are not uniformly distributed within hippocampus. Moreover, alterations different hippocampal layers may reflect distinct pathological processes. 7 T MRI dramatically improves visualization subregions layers. this study, we aimed to assess whether can detect volumetric changes in vivo patients with AD. We studied four AD seven control subjects. MR...
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects different studies. However, extensive characterization IHI a large sample not yet performed. Furthermore, it unclear whether are restricted to medial-temporal lobe or associated with more changes. Here, we studied characteristics community-based 2008 IMAGEN database and their association extra-hippocampal variations. presence...
Prediction is held to be a fundamental process underpinning perception, action, and cognition. To examine the time course of prediction error signaling, we recorded intracranial EEG activity from nine presurgical epileptic patients while they listened melodies whose information theoretical predictability had been characterized using computational model. We examined oscillatory in superior temporal gyrus (STG), middle (MTG), pars orbitalis inferior frontal gyrus, lateral cortical areas...