A5066910788- Functional Brain Connectivity Studies
- Morphological variations and asymmetry
- EEG and Brain-Computer Interfaces
- Medical Image Segmentation Techniques
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Image Retrieval and Classification Techniques
- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Hemispheric Asymmetry in Neuroscience
- Neural Networks and Applications
- Genetic Associations and Epidemiology
- Tissue Engineering and Regenerative Medicine
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Muscle Physiology and Disorders
- Treatment of Major Depression
- Neurobiology of Language and Bilingualism
- Genomic variations and chromosomal abnormalities
- Neural and Behavioral Psychology Studies
- Health, Environment, Cognitive Aging
Inserm
2013-2024
Centre National de la Recherche Scientifique
2013-2024
Institut de Recherche en Informatique et Systèmes Aléatoires
2018-2024
Université de Rennes
2018-2024
Institut des Sciences Cognitives Marc Jeannerod
2021
Institut du Cerveau
2012-2020
University College London
2016-2020
Institut national de recherche en informatique et en automatique
2013-2020
Université Rennes 2
2019
Sorbonne Université
2011-2018
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects different studies. However, extensive characterization IHI a large sample not yet performed. Furthermore, it unclear whether are restricted to medial-temporal lobe or associated with more changes. Here, we studied characteristics community-based 2008 IMAGEN database and their association extra-hippocampal variations. presence...
Abstract Combining EEG and fMRI allows for integration of fine spatial accurate temporal resolution yet presents numerous challenges, noticeably if performed in real-time to implement a Neurofeedback (NF) loop. Here we describe multimodal dataset acquired simultaneously during motor imagery NF task, supplemented with MRI structural data. The study involved 30 healthy volunteers undergoing five training sessions. We showed the potential merit simultaneous EEG-fMRI previous work. illustrate...
Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common temporal lobe epilepsy (TLE), but little is known about the relationship of morphology with memory. We aimed to relate surface-shape patterns verbal visual learning.We analyzed surface shapes on high-resolution magnetic resonance images Adult Memory Information Processing Battery 145 unilateral refractory TLE patients undergoing surgery, a validation set 55 patients, 39 age- sex-matched...
Measures of brain activity through functional magnetic resonance imaging (fMRI) or electroencephalography (EEG), two complementary modalities, are ground solutions in the context neurofeedback (NF) mechanisms for rehabilitation protocols. While NF-EEG (in which real-time scores computed from EEG signals) has been explored a very long time, NF-fMRI fMRI appeared more recently and provides robust results specific training. Using simultaneously bi-modal sessions (NF-EEG-fMRI, EEG) is promising...
Abstract Auditory hallucinations (AHs) are certainly the most emblematic experiences in schizophrenia, but visual (VHs) also commonly observed this developmental psychiatric disorder. Notably, several studies have suggested a possible relationship between clinical variability hallucinations′ phenomenology and differences brain development/maturation. In impairments of hippocampus, medial temporal structure involved mnesic neuroplastic processes, been repeatedly associated with...
Incomplete hippocampal inversion (IHI), also called malrotation, is a frequent atypical anatomical pattern of the hippocampus. Because crucial implication hippocampus in Major Depressive Disorder (MDD) and neurodevelopmental hypothesis MDD, we aimed to assess prevalence IHI patients with link volume (HV) impact on predictive value HV for response remission after antidepressant treatment. (right left, partial total scores) were assessed 60 current Episode (MDE) context MDD matched controls....
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such frontotemporal dementia or Alzheimer's disease, can be observed in key brain structures years before any clinical symptoms are present. Atrophy most commonly captured volume change and shape changes these typically not analysed despite being potentially more sensitive than summary statistics over entire structure. this paper we...
ABSTRACT Neurofeedback (NF) allows to exert self-regulation over specific aspects of one’s own brain activity by returning information extracted in real-time from measures. These measures are usually acquired a single modality, most commonly electroencephalography (EEG) or functional magnetic resonance imaging (fMRI). EEG-fMRI-neurofeedback (EEG-fMRI-NF) is new approach that consists providing NF based simultaneously on EEG and fMRI signals. By exploiting the complementarity these two...
Incomplete hippocampal inversion (IHI), also called malrotation, is an atypical presentation of the hippocampus present in about 20% healthy individuals. Here we conducted first genome-wide association study (GWAS) IHI to elucidate genetic underpinnings that may contribute incomplete during brain development. A total 1381 subjects contributed discovery cohort obtained from IMAGEN database. The incidence rate was 26.1%. Loci with P<1e-5 were followed up a validation comprising 161 PING study....
Abstract Combining EEG and fMRI allows for integration of fine spatial accurate temporal resolution yet presents numerous challenges, noticeably if performed in real-time to implement a Neurofeedback (NF) loop. Here we describe multimodal dataset acquired simultaneously during motor imagery NF task, supplemented with MRI structural data. The study involved 30 healthy volunteers undergoing five training sessions. We showed the potential merit simultaneous EEG-fMRI previous work. illustrate...
This article presents a new approach for template-based analysis of anatomical variability in populations, the framework Large Deformation Diffeomorphic Metric Mappings and mathematical currents. We propose fast which template is computed using diffeomorphic iterative centroid method. Statistical then performed on initial momenta that define deformations between each individual subject. applied to study hippocampus 134 patients with Alzheimer's disease (AD) 160 elderly control subjects. show...
In this paper, we propose an approach for template-based shape analysis of large datasets, using diffeomorphic centroids as atlas shapes. Diffeomorphic centroid methods fit in the Large Deformation Metric Mapping (LDDMM) framework and use kernel metrics on currents to quantify surface dissimilarities. The statistical is based a Kernel Principal Component Analysis (Kernel PCA) performed set initial momentum vectors which parametrize deformations. We tested different datasets hippocampal...
Brainhack is an innovative meeting format that promotes scientific collaboration and education in open inclusive environment. Departing from the formats of typical workshops, these events are based on grassroots projects training, foster reproducible practices. We describe here multifaceted, lasting benefits Brainhacks for individual participants, particularly early career researchers. further highlight unique contributions can make to research community, contributing progress by...
The incomplete hippocampal inversion (IHI) is an atypical anatomical pattern of the hippocampus. However, hippocampus not a homogeneous structure, as it consists segregated subfields with specific characteristics. While IHI related to whole volume, higher scores have been associated smaller CA1 in aging. Although segmentation challenging due their small size, there are algorithms allowing automatic segmentation. By using Human Connectome Project dataset healthy young adults, we first tested...
Abstract Developmental topographical disorientation (DTD) refers to the lifelong inability orient by means of cognitive maps in familiar surroundings despite otherwise well‐preserved general functions, and absence any acquired brain injury or neurological condition. While reduced functional connectivity between hippocampus other regions has been reported DTD individuals, no structural differences gray matter tissue for whole neither were detected. Considering that human is main structure...
Incomplete Hippocampal Inversion (IHI), sometimes called hippocampal malrotation, is an atypical anatomical pattern of the hippocampus found in about 20% general population. IHI can be visually assessed on coronal slices T1 weighted MR images, using a composite score that combines four criteria. has been associated with several brain disorders (epilepsy, schizophrenia). However, these studies were based small samples. Furthermore, factors (genetic or environmental) contribute to genesis are...