A5101665805- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Phonocardiography and Auscultation Techniques
- Prion Diseases and Protein Misfolding
- Data Management and Algorithms
- Renal and Vascular Pathologies
- ECG Monitoring and Analysis
- Esophageal and GI Pathology
- Advanced Database Systems and Queries
- Colorectal Cancer Screening and Detection
- Data Stream Mining Techniques
- Tendon Structure and Treatment
- Colorectal Cancer Surgical Treatments
- Neurogenetic and Muscular Disorders Research
- Thyroid and Parathyroid Surgery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Transplantation Outcomes and Treatments
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Minimally Invasive Surgical Techniques
- Vascular Tumors and Angiosarcomas
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Imbalanced Data Classification Techniques
Hospital de Santo António
2024
Hospital de Santa Maria
2013-2024
University of Lisbon
2024
Instituto Politécnico de Leiria
2024
Centre Orthopédique Santy
2024
Générale de Santé
2024
Hôpital Privé Jean Mermo
2024
INESC TEC
2021-2022
National Human Genome Research Institute
2022
National Institutes of Health
2022
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin (GRN), microtubule-associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9orf72) genes. Previous small studies have reported presence of cerebral white matter hyperintensities (WMH) genetic FTD but this has not been systematically studied across different mutations. In study WMH were assessed 180 participants from Initiative (GENFI) with 3D T1- T2-weighed magnetic resonance images: 43...
Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around third of cases having autosomal dominant inheritance. There wide variability in phenotype even within affected families, raising questions about the determinants progression disease and age at onset. It has been recently demonstrated that cognitive reserve, as measured by years formal schooling, can counteract ongoing pathological process. The TMEM106B genotype also found to be modifier onset frontotemporal...
We investigated whether progranulin plasma levels are predictors of the presence gene (GRN) null mutations or development symptoms in asymptomatic at risk members participating Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 carriers, and 77 noncarriers. In addition, we evaluated a possible role TMEM106B rs1990622 as genetic modifier correlated gray-matter atrophy. Plasma mean ± SD patients carriers were significantly decreased compared with noncarriers (30.5 13.0 27.7...
Background: Open reduction and internal fixation (ORIF) with a locking plate is popular surgical treatment for proximal humeral fractures (PHF). This study aimed to assess the occurrence of complications in elderly patients PHF treated surgically using ORIF investigate potential differences between by “shoulder surgeons” “non-shoulder surgeons.”Methods: A retrospective was conducted single-center database identify aged ≥70 years who underwent January 1, 2011, December 31, 2021. Data on Neer...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such frontotemporal dementia or Alzheimer's disease, can be observed in key brain structures years before any clinical symptoms are present. Atrophy most commonly captured volume change and shape changes these typically not analysed despite being potentially more sensitive than summary statistics over entire structure. this paper we...
The bone–patellar tendon–bone (BPTB) autograft or allograft is a well-established option for primary revision anterior cruciate ligament (ACL) reconstruction. However, although the length and width of graft are relatively consistent, its thickness unpredictable can impact biomechanical properties ACL graft. This technical note describes technique arthroscopic reconstruction called "BPTB-plus" technique, which consists BPTB augmented by gracilis tendon.
Cardiac auscultation is the key exam to screen cardiac diseases both in developed and developing countries. A heart sound procedure can detect presence of murmurs point a diagnosis, thus it an important first-line assessment also cost-effective tool. The design automatic recommendation systems based on play role boosting accuracy pervasiveness screening tools. One such as step, consists detecting fundamental states, process known segmentation. faulty segmentation or wrong estimation rate...
Cardiac auscultation is the key screening procedure to detect and identify cardiovascular diseases (CVDs). One of many steps automatically CVDs using auscultation, concerns detection delimitation heart sound boundaries, a process known as segmentation. Whether include or not segmentation step in signal classification pipeline nowadays topic discussion. Up our knowledge, outcome algorithm has been used almost exclusively align different segments according heartbeat. In this paper, need for...
Laparoscopic sleeve gastrectomy (LSG)-related fistulas are important and potentially fatal complications. We aimed at determining the incidence, predictive factors, management of recurrence post-LSG fistulas.This is a retrospective cohort study 12 consecutive patients with LSG managed endoscopically between 2008 2013. analyzed factors associated efficacy primarily endoscopic approach to manage fistula recurrence.The average age detection after was 43.3 ± 10.9 years, 10 (83%) were female. The...
Acute lower gastrointestinal bleeding is one of the most common causes hospital admission. However, massive uncommon and mainly due to hemorrhoidal in elderly patients receiving anticoagulant therapy. We present a rare case rectal haemorrhage with an cause.
Aim Debridement, antibiotics and implant retention (DAIR) is recommended for acute postoperative late prosthetic joint infection (PJI). There are two recommend scores to predict its outcome, KLIC CRIME 80 respectively. They have not been widely adopted decision making. We aim evaluate them in predicting DAIR failure our cohort. Method All patients submitted after total hip or knee PJI, between 2010 2021, with a minimum one-year follow-up, were retrospectively evaluated. excluded tumoral...
Recently, soft attention mechanisms have been successfully used in a wide variety of applications such as the generation image captions, text translation, etc. This mechanism attempts to mimic visual cortex human brain by not analyzing all objects scene equally, but looking for clues (or salient features) which might give more compact representation environment. In doing so, can process information quickly and without overloading. Having learned this lesson, paper, we try make bridge from...
Introduction: Shortage of high quality donors led to an increasing need compatible organs: grafts with multiple renal arteries (MRA) are one the solutions, although being a potential risk factor that can impair outcomes. The aim this study is provide view our experience in transplantation and compare outcome between single artery (SRA) groups.
 Material Methods: A retrospective 2989 kidney transplants was performed department January 1980 February 2017: demographic characteristics...
The rapid growth in data science and technology, particular the complexity volume of Big Data, has introduced new challenges for research community. Several these are related to nature generation, since most sources produce continuously. Examples include sensor wireless networks, radio frequency identification, customer click streams, telephone records, multimedia scientific data, sets retail chain transactions, among others. These called ordered sequences instances that can typically be...
The rapid growth in data science and technology, particular the complexity volume of Big Data, has introduced new challenges for research community. Several these are related to nature generation, since most sources produce continuously. Examples include sensor wireless networks, radio frequency identification, customer click streams, telephone records, multimedia scientific data, sets retail chain transactions, among others. These called ordered sequences instances that can typically be...