Alyssa James
A5019653039- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Legal Systems and Judicial Processes
- Helicobacter pylori-related gastroenterology studies
- Allergic Rhinitis and Sensitization
- Congenital Ear and Nasal Anomalies
- Food Allergy and Anaphylaxis Research
- Eosinophilic Disorders and Syndromes
- Blood disorders and treatments
- Diabetes and associated disorders
- Global Public Health Policies and Epidemiology
- Immune Cell Function and Interaction
- Reproductive Health and Technologies
- Food Security and Health in Diverse Populations
- Parasitic Infections and Diagnostics
- T-cell and B-cell Immunology
- Metabolism and Genetic Disorders
- Adrenal Hormones and Disorders
- Pediatric health and respiratory diseases
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Workplace Health and Well-being
- Genetic Neurodegenerative Diseases
National Institute of Allergy and Infectious Diseases
2021-2024
National Institutes of Health
2021-2024
Children's National
2020-2021
Indiana University
2012
Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These were recently reported to account for at least 10% cases life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients 21 kindreds seven countries, aged between 8 48 yr infected SARS-CoV-2 since February 2020. The...
STAT6 (signal transducer and activator of transcription 6) is a factor that plays central role in the pathophysiology allergic inflammation. We have identified 16 patients from 10 families spanning three continents with profound phenotype early-life onset immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, anaphylaxis. The cases were either sporadic (seven...
Ass'N, http://www.americanpregnancy.org/main/statistics.html (last visited Aug. 17, 2012) (There are sixty million women of child bearing age (15-44) in the United States; six these deal with infertility.).