A5052156750- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Amyotrophic Lateral Sclerosis Research
- Intracranial Aneurysms: Treatment and Complications
- Migraine and Headache Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Folate and B Vitamins Research
- Asthma and respiratory diseases
- Bioinformatics and Genomic Networks
- Neurological Complications and Syndromes
- Mental Health Research Topics
- Respiratory Support and Mechanisms
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transcranial Magnetic Stimulation Studies
- Neonatal Respiratory Health Research
- Gene Regulatory Network Analysis
- Body Composition Measurement Techniques
- Intensive Care Unit Cognitive Disorders
- Prion Diseases and Protein Misfolding
University of Pavia
2016-2025
University of Brescia
2005-2024
Université de Tours
2024
Inserm
2024
Centre Hospitalier Universitaire Amiens-Picardie
2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Cognitive Neuroimaging Lab
2023
Azienda Ospedaliera Sant'Andrea
2009-2016
Objective: Compared with standard medical therapy (SMT), noninvasive ventilation (NIV) does not reduce the need for reintubation in unselected patients who develop respiratory failure after extubation. The goal of this study was to assess whether early application NIV, immediately extubation, is effective preventing postextubation an at-risk population. Design: Multiple-center, randomized controlled study. Setting: Multiple hospitals. Patients: Ninety-seven consecutive similar baseline...
This study aimed to assess whether non-invasive brain stimulation with transcranial alternating current at gamma-frequency (γ-tACS) applied over the precuneus can improve episodic memory and modulate cholinergic transmission by modulating cerebral rhythms in early Alzheimer's disease (AD).In this randomized, double-blind, sham controlled, crossover study, 60 AD patients underwent a clinical neurophysiological evaluation including assessment of pre post minutes treatment γ-tACS targeting or...
Background and Purpose — The role of mild hyperhomocysteinemia as a risk factor for cerebral ischemia may depend on stroke subtype. To test this hypothesis, we undertook prospective case-control study group patients with spontaneous cervical artery dissection (sCAD), atherothrombotic (non-CAD), control subjects. Methods Fasting total plasma homocysteine (tHcy) concentration, C677T MTHFR genotype, 844ins68bp CBS genotype were determined in 25 sCAD, 31 <45 years age non-CAD ischemic stroke,...
The pathogenic link between patent foramen ovale (PFO) and stroke remains unknown in most cases. We investigated the association inherited thrombophilic disorders PFO-related strokes a series of young adults setting case-control study.We 125 consecutive subjects (age, 34.7+/-7.3 years) with ischemic 149 age- sex-matched control subjects. PFO was assessed all patients transcranial Doppler sonography intravenous injection agitated saline according to standardized protocol. Genetic analyses for...
The aim of our study was to measure values maximal inspiratory (MIP) and expiratory (MEP) mouth pressures in 625 (266 male, 359 female) clinically functionally normal subjects drawn out a sample representative the general population. MEP (near TLC FRC) found be significantly higher when compared with MIP RV FRC), male were than those female subjects. at FRC closely related, as near FRC. Among tested body-size variables, body surface area (BSA) for all parameters had highest degree...
Objective: older patients usually receive less invasive and costly hospital care, even if they meet the criteria for Intensive Care Unit admission or have a 'do not intubate'(DNI) order. The aim of this randomised, controlled trial was to assess effectiveness non-invasive mechanical ventilation (NIV) versus standard medical therapy (SMT) in reducing need intubation, improving survival respiratory distress very old with acute hypercapnic failure (AHRF). Participants design: eighty-two aged...
Background— Data on long-term risk and predictors of recurrent thrombotic events after ischemic stroke at a young age are limited. Methods Results— We followed 1867 patients with first-ever who were 18 to 45 years (mean age, 36.8±7.1 years; women, 49.0%), as part the Italian Project Stroke in Young Adults (IPSYS). Median follow-up was 40 months (25th 75th percentile, 53). The primary end point composite stroke, transient attack, myocardial infarction, or other arterial events. One hundred...
Transcranial magnetic stimulation (TMS) has been suggested as a reliable, noninvasive, and inexpensive tool for the diagnosis of neurodegenerative dementias. In this study, we assessed classification performance TMS parameters in differential common disorders, including Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal (FTD).We performed multicenter study enrolling patients referred to 4 centers Italy, accordance Standards Reporting Diagnostic Accuracy. All underwent...
Abstract Background The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral motor impairment (MCBMI). objective study was to validate research MCBMI-FTD in a cohort genetically confirmed FTD cases against healthy controls. Methods A total 398 participants were enrolled, 117 whom carriers an pathogenic variant with symptoms, while 281 non-carrier family members...
The lack of available reference values arterial PO2, particularly for elderly persons, led us to study a sample 194 normal nonsmoking subjects, equally distributed over all age ranges from 40 90 yr. radial artery was punctured and blood samples were taken analyzed on an automated, computerized gas-analyzer. trend the mean PaO2 in 5-yr class intervals showed clear decline up 70- 74-yr class, then inversion. two regression lines intersecting at this point provided better fit data than did...
The objective was to investigate the role of C677T MTHFR polymorphism in migraine pathogenesis and migraine-ischemic stroke pathway.A first genotype-migraine association study conducted on 100 patients with aura (MA), 106 without (MO), 105 subjects migraine, which provided evidence favor TT677 genotype increased risk MA compared both control (OR, 2.48; 95% CI, 1.11 5.58) MO 2.21; 1.01 4.82). Based these findings, mediational models genotype-migraine-stroke pathway were fitted a group...
<b>Objective: </b> In CSF, extended (55 kDa) and truncated (33 tau forms have been previously recognized, the 33 kDa/55 kDa ratio has found significantly reduced in progressive supranuclear palsy (PSP) vs other neurodegenerative disorders. The aim of this study was to evaluate diagnostic value CSF form as a biomarker PSP correlate structural anatomic changes measured by means voxel-based morphometry (VBM) decrease. <b>Methods: A total 166 subjects were included (21 PSP, 20 corticobasal...
A potential role of perfusion CT (PCT) in selecting patients with stroke for reperfusion therapies has been recently advocated. The purpose the study was to assess reliability PCT predicting clinical outcome acute ischemic treated intra-arterial thrombolysis (IAT).
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
Cerebellar ataxias represent a heterogeneous group of disabling disorders characterized by motor and cognitive disturbances, for which no effective treatment is currently available. In this randomized, double-blind, sham-controlled trial, followed an open-label phase, we investigated whether with cerebello-spinal transcranial direct current stimulation (tDCS) could improve both symptoms in patients neurodegenerative ataxia at short long-term. Sixty-one were randomized two groups the first...
To evaluate the performance of a Random Forest (RF) classifier on Transcranial Magnetic Stimulation (TMS) measures in patients with Mild Cognitive Impairment (MCI).We applied RF TMS obtained from multicenter cohort MCI, including MCI-Alzheimer's Disease (MCI-AD), MCI-frontotemporal dementia (MCI-FTD), MCI-dementia Lewy bodies (MCI-DLB), and healthy controls (HC). All underwent assessment at recruitment (index test), application reference clinical criteria, to predict different...
Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of infection. A random cross sectional study was performed H infection in adult San Marino, a European country with high gastric cancer rate, to assess its prevalence and evaluate relations gastrointestinal disease. In 2237 subjects (77% initial sample) IgG antibodies were detected enzyme linked immunosorbent assay (ELISA) immunoblotting. questionnaire including questions about occupation,...
The pathophysiology of spontaneous cervical artery dissection (sCAD) is largely unknown. An association with migraine has been suggested, but not definitively proven. In the setting a hospital-based prospective case-control study we assessed personal and family history in 72 patients sCAD, cerebral infarct unrelated to CAD (non-CAD) control subjects. Personal was significantly associated sCAD compared non-CAD (59.7% vs. 30.6%; OR 3.14; 95% CI 1.41-7.01) controls (18.1%; 7.41; 3.11-17.64). As...
Frontotemporal dementia (FTD) is the second most prevalent form of early onset after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. identified 2 potential loci for FTD. Suggestive SNPs reached p-values ∼10(-7) odds ratio > 2.5 (2p16.3) 1.5 (17q25.3). alleles at 17q25.3 disease-associated haplotype causing decreased...
Seizures are common neurological consequences of stroke. Although a number factors including stroke severity on admission, cortical involvement, and subtype have been consistently associated with post-stroke seizures, the effect that medical complications stroke, occurring in very acute phase, might such risk has never adequately explored. In present study we aimed at determining extent to which within first week influence early seizures (ES).Data consecutive patients first-ever included...
Objective. Functional dyspepsia (FD) is a frequent clinical finding in western world. The aim of this study to compare the efficacy ginger and artichoke supplementation versus placebo treatment FD. Methods. A prospective multicentre, double blind, randomized, controlled, parallel-group comparison supplement over period 4 weeks was performed. Two capsules/day were supplied (before lunch dinner) 126 FD patients (supplementation/placebo: 65/61). Results . After 14 days treatment, only group...
Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around third of cases having autosomal dominant inheritance. There wide variability in phenotype even within affected families, raising questions about the determinants progression disease and age at onset. It has been recently demonstrated that cognitive reserve, as measured by years formal schooling, can counteract ongoing pathological process. The TMEM106B genotype also found to be modifier onset frontotemporal...
The choice of the interface for noninvasive ventilation (NIV) is a key factor in NIV success. We hypothesised that new helmet specifically design to improve performance hypercapnic patients would be clinically equivalent standard oronasal mask. In multicentre, short-term, physiological, randomised trial chronic obstructive pulmonary disease facing an acute respiratory failure episode, we compared changes arterial blood gases (ABGs) and tolerance score obtained using or mask, and, as...
Abstract INTRODUCTION Modeling the survival rate in syndromes associated with frontotemporal lobar degeneration (FTLD) is essential to assess disease trajectories. METHODS In 262 patients FTLD, we considered plasma neurofilament light chain (NfL), glial fibrillary acidic protein, brain‐derived tau, phosphorylated tau217 and amyloid beta (Aβ42/Aβ40). The FTLD Survival Score (FTLD‐SS) was calculated by β coefficients of variables independently rate. RESULTS Increased NfL levels ( p <...