A5000497722- Acute Ischemic Stroke Management
- Multiple Sclerosis Research Studies
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Peripheral Neuropathies and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Polyomavirus and related diseases
- Neurological Complications and Syndromes
- Parkinson's Disease Mechanisms and Treatments
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Amyotrophic Lateral Sclerosis Research
- Intracranial Aneurysms: Treatment and Complications
- Hereditary Neurological Disorders
- Adenosine and Purinergic Signaling
- Neonatal and fetal brain pathology
- Myasthenia Gravis and Thymoma
- Neurological disorders and treatments
- Migraine and Headache Studies
- Prion Diseases and Protein Misfolding
University of Ferrara
2016-2025
IRCCS San Camillo Hospital
2024-2025
Arcispedale Sant'Anna
2012-2025
Policlinico Umberto I
2024
Sapienza University of Rome
2024
University of Florence
2024
Humboldt-Universität zu Berlin
2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2023
Centre Hospitalier Universitaire de Tours
2023
<b><i>Objective:</i></b> To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy the puerperium. <b><i>Methods:</i></b> A structured clinical interview, assessing symptoms since beginning of pregnancy, was performed to population 642 pregnant women at time delivery follow-up evaluation (1, 3, 6 months after delivery). Main hematologic tests were also evaluated. woman considered affected if she met International RLS Study Group criteria for...
Background: Obesity may be a risk factor for developing multiple sclerosis (MS). Objective: We examined if body size influences the of MS in population-based, case control study. Methods: A total 953 cases and 1717 controls from Norway 707 1333 Italy reported their by choosing silhouette 1 to 9 (largest) every fifth year age 5 30 at time The size-related was defined odds ratios (ORs) logistic regression analyses adjusting age, smoking outdoor activity. Results: In large (silhouettes 6–9)...
Objectives: The objective of this paper is to estimate the association between multiple sclerosis (MS) and measures sun exposure in specific age periods Norway Italy. Methods: A total 1660 MS patients 3050 controls from Italy who participated a multinational case-control study (EnvIMS) reported habits during childhood adolescence. Results: significant infrequent summer outdoor activity increased risk was found strongest ages 16 18 years (odds ratio (OR) 1.83, 95% confidence interval (CI)...
In this study, we employed a sensitive activity assay system to measure cerebrospinal fluid (CSF) and serum levels of active matrix metalloproteinase-9 (MMP-9) in 37 relapsing-remitting (RR), 15 secondary progressive (SP) nine primary (PP) multiple sclerosis (MS) patients, grouped according clinical magnetic resonance imaging (MRI) evidence disease activity. We also studied, as neurological controls, 48 patients with other inflammatory disorders (OIND) non-inflammatory (NIND). To assess...
<h3>Background</h3> Studies have reported circadian variation in the onset of ischemic stroke, which may carry important pathophysiological implications. However, there is no detailed information about variations among subtypes stroke. <h3>Objective</h3> To determine whether subgroups patients with stroke specific clinical characteristics would exhibit different patterns, to more systematically examine role possible triggering or precipitating factors. <h3>Design and Setting</h3> Analysis...
We sought to register the incidence rate, risk factors, and case-fatality rate of all new cases first-ever-in-a-lifetime stroke in province Beluno, Italy. This study aimed provide an epidemiological survey cerebrovascular disease that could supply investigative objectives support information for regional healthcare facilities planning.We undertook a prospective population-based territory 1st, 2nd, 3rd, 4th local health units Belluno, area located northeast Italy (population, 211 389).In...
The antagonistic interaction between adenosine and dopamine receptors could have important pathophysiological therapeutic implications in Parkinson's disease (PD). primary aim of this study was to investigate the expression, affinity, density A1, A2A, A2B, A3 (ARs) D2 (D2Rs) PD. An increase A2AAR putamen found. presence functionality ARs human lymphocyte neutrophil membranes from patients with PD revealed a specific alteration compared healthy subjects. A statistically significant linear...
Pregnancy is a risk factor for transient restless legs syndrome, which usually recovers during the postdelivery period. The goal of present survey to investigate whether syndrome pregnancy represents later development syndrome.A long-term follow-up study, planned as an extension previous on pregnancy, was carried out. After mean interval 6.5 years, 207 parous women were contacted again compare incidence among subjects who never experienced symptoms with those reported previously investigated...
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
Background and Purpose: As numerous questions remain about the best anesthetic strategy during thrombectomy, we assessed functional radiological outcomes in stroke patients treated with thrombectomy presence of general anesthesia (GA) versus conscious sedation (CS) local (LA). Methods: We conducted a cohort study on prospectively collected data from 4429 enrolled Italian Registry Endovascular Treatment Acute Stroke. Results: GA was used 2013 patients, CS 1285 LA 1131 patients. The rates...
Abstract Background The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for evaluation blood–cerebrospinal barrier (B-CSF-B) permeability. For years QAlb was considered only as an age-related parameter but recently it has also been associated to sex. aim present study explore impact sex in determination B-CSF-B dysfunction. Methods analysis retrospectively conducted on subjects consecutively admitted neurological ward. CSF and serum levels were measured...
Background and Purpose: To evaluate outcome safety of endovascular treatment beyond 6 hours onset ischemic stroke due to large vessel occlusion in the anterior circulation, routine clinical practice. Methods: From Italian Registry Endovascular Thrombectomy, we extracted data patients treated for known hours. Additional inclusion criteria were prestroke modified Rankin Scale score ≤2 ASPECTS ≥6. Patients selected on individual basis by a combination CT perfusion mismatch (difference between...
Severe hematoma expansion (sHE) has the strongest impact on intracerebral hemorrhage (ICH) outcome. We investigated predictors of sHE.
<b><i>Objective:</i></b> To verify incidence rates and their temporal trend in a homogeneous, ethnically, genetically distinct population of central Sardinia (the Nuoro province). <b><i>Background:</i></b> Intensive epidemiologic studies carried out since the 1970s have suggested that prevalence MS are much higher this Mediterranean island compared with those found on mainland Italy. <b><i>Methods:</i></b> The study area had approximately 274,000 people 1991 census. authors adopted complete...
Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin was measured cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 other inflammatory neurological diseases 18 non-inflammatory liquid chromatography-mass spectrometry. There were no significant differences concentrations of 25-hydroxyvitamin D, the fluid:serum ratio significantly lower MS compared (p=0.0012) (p=0.041) patients. The serum...
Women have about twice the risk of developing multiple sclerosis (MS) compared with men, a ratio that seems to be increasing. Most studies show female patients seem more favourable outcome disease. We studied gender-specific impact MS on health-related quality life. surveyed population prevalence in Ferrara, Italy. Data were extracted from registry study area. Health-related life was assessed using MSQOL54 questionnaire. analysed 370 (105 men and 265 women). They had worse scores than...
The aim of this study was to estimate the prevalence temporomandibular disorders (TMD) symptoms in an Italian population sample, focusing on gender and age differences. We selected 2005 individuals by telephone survey asked them about TMD like difficulty jaw movement, pain joint sounds. Also, tooth-clenching and/or tooth-grinding habits were investigated. Of population, 8·1% reported limitations movements, 5·1% 33·3% Furthermore, 37·3% tooth-clenching/tooth-grinding. Confidence intervals...
Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed nomogram predicting in patients with large vessel occlusion anterior circulation who received bridging intravenous thrombolysis (training set), validate model by using cohort treated direct (test set). Methods— We conducted study on prospectively collected data from 3714 enrolled IER (Italian Registry...
The objective of this paper was to explore the utility time maximum concentration (Tmax )-based target mismatch on computed tomography perfusion (CTP) in predicting radiological and clinical outcomes patients with acute ischemic stroke (AIS) anterior circulation large vessel occlusion (LVO) selected for endovascular treatment (EVT).Patients AIS underwent CTP within 24 hours from onset followed by EVT. Critically hypoperfused tissue core volumes were automatically calculated using Tmax...