A5033637668- Multiple Sclerosis Research Studies
- Sleep and Wakefulness Research
- Sleep and related disorders
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Polyomavirus and related diseases
- COVID-19 and Mental Health
- Systemic Sclerosis and Related Diseases
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Long-Term Effects of COVID-19
- Circadian rhythm and melatonin
- Carcinogens and Genotoxicity Assessment
- Reproductive System and Pregnancy
- Social and Educational Sciences
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
Linköping University
2016-2025
Uppsala University
2016-2025
Uppsala University Hospital
2014-2024
Linköping University Hospital
2005-2023
Lasarettet i Motala
2004-2022
Örebro County Council
2014
Karolinska Institutet
1998-2006
Sudden onset headache is a common condition that sometimes indicates life- threatening subarachnoid haemorrhage (SAH) but mostly harmless. We have performed prospective study of 137 consecutive patients with this kind (thunderclap = TCH). The examination included CT scan, CSF and follow-up no SAH during the period between 2 days 12 months after attack. incidence was 43 per 100 000 inhabitants > 18 years age year; 11.3% TCH had SAH. Findings in other indicated cerebral infarction (five),...
Objective: Physical disability explains only part of the reduced quality life found among multiple sclerosis (MS) patients. Bladder dysfunction and sexual disturbance are frequent distressing problems for MS We therefore estimated relationship between presence degree disturbance/bladder patients' as measured by SF-36 Health Survey. Methods: performed a cross-sectional study all individuals with onset 1976 1986 in Hordaland County, Norway. The disease duration at examination was 9-19 years;...
Conventional magnetic resonance imaging (MRI) has relatively long scan times for routine examinations, and the signal intensity of images is related to specific MR scanner settings. Due imperfections automatic optimizations, it impossible compare in terms absolute image intensity. Synthetic MRI, a method generate conventional based on quantification, potentially both decreases examination time enables quantitative measurements.To evaluate synthetic MRI brain clinical setting by assessment...
Background: Obesity may be a risk factor for developing multiple sclerosis (MS). Objective: We examined if body size influences the of MS in population-based, case control study. Methods: A total 953 cases and 1717 controls from Norway 707 1333 Italy reported their by choosing silhouette 1 to 9 (largest) every fifth year age 5 30 at time The size-related was defined odds ratios (ORs) logistic regression analyses adjusting age, smoking outdoor activity. Results: In large (silhouettes 6–9)...
Objectives: The objective of this paper is to estimate the association between multiple sclerosis (MS) and measures sun exposure in specific age periods Norway Italy. Methods: A total 1660 MS patients 3050 controls from Italy who participated a multinational case-control study (EnvIMS) reported habits during childhood adolescence. Results: significant infrequent summer outdoor activity increased risk was found strongest ages 16 18 years (odds ratio (OR) 1.83, 95% confidence interval (CI)...
Summary Many people report suffering from post‐acute sequelae of COVID‐19 or “long‐COVID”, but there are still open questions on what actually constitutes long‐COVID and how prevalent it is. The current definition is based voting using the Delphi‐method by WHO post‐COVID‐19 working group. It emphasizes long‐lasting fatigue, shortness breath cognitive dysfunction as core symptoms COVID‐19. In this international survey study consisting 13,628 subjects aged 18–99 years 16 countries Asia,...
Despite the interest in neuroimaging of working memory, little is still known about neurobiology complex memory tasks that require simultaneous manipulation and storage information. In addition to central executive network, we assumed recently described salience network (involving anterior insular cortex cingulate cortex) might be particular importance complex, effortful processing. Method: Healthy participants (n=26) suffering from problems related Kleine-Levin syndrome (a specific form...
Among individuals diagnosed with the chronic neurologic disease, multiple sclerosis (MS), a majority suffers from fatigue, which strongly influences their every-day-life. The aim of this study was to investigate work capacity and health-related quality life (HRQoL) in group MS patients also if HRQoL could be predicted by background factors, heat sensitivity, cognitive dysfunction, emotional distress or degree disability. A descriptive, cross-sectional, designed survey undertaken...
Background: It is currently unknown whether early immunomodulatory treatment in relapsing–remitting MS (RRMS) can delay the transition to secondary progression (SP). Objective: To compare time interval from onset SP patients with RRMS between a contemporary cohort, treated first generation disease modifying drugs (DMDs), and historical control cohort. Methods: We included cohort of DMDs, obtained Swedish National Registry (disease 1995–2004, n = 730) population-based incidence (onset...
The aim was to explore the thalamo-striato-cortical theory of central fatigue in multiple sclerosis (MS) patients with self-reported fatigue. If correctly predicted based on disruptions network, we expected altered brain activation this network MS participants while performing a complex cognitive task that challenged fatigue.MS were examined by functional magnetic resonance imaging (fMRI) during performance working memory task. In task, effort parametric design, which modeled cerebral...
OBJECTIVE Magnetic resonance imaging tends to underestimate the extent of diffuse low-grade gliomas (DLGGs). With aim studying presence tumor cells outside radiological border, authors developed a method correlating MRI findings with histological data in patients suspected DLGGs whom en bloc resections were performed. METHODS Five DLGG suitable for resection recruited from an ongoing prospective study. Sections entire immunostained antibodies against mutated IDH1 protein (IDH1-R132H). images...
Narcolepsy is a chronic sleep disorder caused by loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function narcolepsy during rest using positron emission tomography (PET) and single photon computed (SPECT). In addition to hypothalamic thalamic dysfunction they showed aberrant prefrontal perfusion glucose metabolism narcolepsy. Given these findings structure narcolepsy, we anticipated that changes functional magnetic resonance...
Background: The lifestyle factors smoking and obesity have been associated with the risk of multiple sclerosis (MS). Physical activity (PA) may also be importance. Objective: To examine association between PA MS in Italy, Norway, Sweden to evaluate possible influence by established factors. Methods: In this case–control study, 1904 cases 3694 controls were asked report their average weekly amounts light vigorous during adolescence on a scale ranging from none more than 3 hours activity. We...
Short nighttime sleep duration impairs the immune response to virus vaccination, and long is associated with poor health status. Thus, we hypothesized that short (<6 h) (>9 sleepers have a higher post-COVID risk than normal sleepers, despite two doses of mRNA vaccine (which has previously been linked lower odds long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core symptom for three months (e.g., shortness breath). Multivariate logistic regression adjusting...
Poststroke depression is a frequent condition and important to treat. The aim of this trial was study the efficacy tolerability sertraline.In 4 Swedish stroke centers, 123 patients (aged 70.7 +/- 9.9 years) were enrolled during period September 1998 January 2001 in randomized, double-blind, placebo-controlled 26-week trial, at mean 128 97 days (range, 3-375 days) after stroke, if they fulfilled DSM-IV criteria major depressive episode (N = 76) or minor disorder 47). primary variable change...
We sought to determine whether Swedish patients with multiple sclerosis (MS) and without oligoclonal bands (OCBs) in the CSF constitute distinct subpopulations, clinically immunogenetically. Our findings indicate that OCB-negative MS shares same clinical features as OCB-positive regarding female predominance, age at onset, proportion of primary progressive cases, rate MRI positivity, disease severity. HLA-DRB1 genotyping results suggest, however, are immunogenetically distinct.
Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating the symptom of fatigue. The need explore this association highlighted. aim study was investigate occurrence heat sensitivity and its relations disease course, disability, common MS-related symptoms ongoing immunosuppressive treatments among 65 years age or younger MS. A cross-sectional designed survey undertaken. questionnaire sent MS-patients an...
In Multiple Sclerosis (MS) the relationship between disease process in normal-appearing white matter (NAWM) and development of lesions is not well understood. this study we used single voxel proton 'Quantitative Magnetic Resonance Spectroscopy' (qMRS) to characterize NAWM thalamus both atypical 'Clinically Definite MS' (CDMS) patients, MRIneg (N = 15) with very few (two or fewer lesions), typical CDMS MRIpos 20) lesions, comparison healthy control subjects 20). addition, metabolite...
Sex ratio in multiple sclerosis has been reported from several geographical areas. The disease is more common women. In Europe the female-to-male varies 1.1 to 3.4. A recent study Canada a significant increase, with time, over last 100 years.The aim of this was analyse any change sex Swedish population.Data MS Register and data National Statistics Office were used estimate by year birth onset.In analysis there 8834 patients (6271 women 2563 men) born between 1931 1985. mean women-to-men...
Introduction: Magnetic Resonance Imaging is a sensitive technique for detecting white matter (WM) MS lesions, but the relation with clinical disability low. Because of this, changes in both 'normal appearing matter' (NAWM) and 'diffusely abnormal (DAWM) have been interest recent years. MR techniques, including quantitative magnetic resonance imaging (qMRI) spectroscopy (qMRS), developed order to detect quantify such changes. In this study, qMRI qMRS were used investigate NAWM DAWM typical...
Objectives Off-label use of rituximab to treat MS patients in Sweden is high, and the need for long-term safety data may not be met. Our objectives were assess rate prescription with multiple sclerosis and, addition, evaluate a single centre sclerosis. Material Methods Review Swedish register was performed study number treated during last 6 years. Investigation also included retrospective review medical files search possible side effects/adverse events all adult at Uppsala University...
The ability to perform effortful tasks is a topic that has received considerable interest in the research of higher functions human brain. Neuroimaging studies show anterior insular and cingulate cortices are involved multitude cognitive require mental effort. In this study, we investigated brain responses effort using with task-difficulty modulations functional magnetic resonance imaging (fMRI). We hypothesized performance involves modulation activation cortices, correlates individual...
Introduction Previous studies have suggested cerebrospinal fluid (CSF) levels of neurofilament light (NFL) and total tau are elevated in Huntington's disease (HD) may be used as markers stage. Biomarkers needed due to the slow progression limitations clinical assessment. This study aims validate role NFL biomarkers HD. Methods CSF was obtained from a cohort HD patients premanifest HD-mutation carriers. Unified Disease Rating Scale (UHDRS) testing performed on all subjects at time sampling....