A5056894881- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Psoriasis: Treatment and Pathogenesis
- Air Quality and Health Impacts
- Sleep and related disorders
- Head and Neck Surgical Oncology
- Climate Change and Health Impacts
- Advanced Biosensing Techniques and Applications
- Sleep and Wakefulness Research
- Vitamin D Research Studies
- Ear Surgery and Otitis Media
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Suicide and Self-Harm Studies
- Mental Health and Patient Involvement
- Indoor Air Quality and Microbial Exposure
- Soft tissue tumors and treatment
- Delphi Technique in Research
University of New Brunswick
2018-2025
Government of New Brunswick
2021
McGill University
2010-2018
McGill University Health Centre
2012-2018
Royal Victoria Hospital
2014-2018
Montreal Neurological Institute and Hospital
2011-2014
Imaging Center
2014
Hospital for Sick Children
2009-2014
Royal Victoria Regional Health Centre
2014
Brigham and Women's Hospital
2014
The incidence of acquired demyelination the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It important that physicians recognize features ADS to facilitate care and appreciate future risk multiple sclerosis (MS).To determine incidence, clinical features, familial autoimmune history, acute management Canadian with ADS.Incidence case-specific data were obtained through Pediatric Surveillance Program from April 1, 2004, March 31, 2007. Before study initiation, a survey...
To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases.We addressed kinetics anti-MOG immunoglobulins a prospective comprising 77 pediatric patients. This was supplemented by cross-sectional analyzing 126 patients with acute demyelination and 62 adult multiple sclerosis (MS). MOG-transfected cells were used for detection antibodies flow cytometry.Twenty-five children who immunoglobulin (Ig) positive at disease...
To determine the impact of pediatric-onset multiple sclerosis (MS) on age-expected brain growth.Whole and regional volumes 36 patients with relapsing-remitting MS onset prior to 18 years age were segmented in 185 longitudinal MRI scans (2-11 per participant, 3-month 2-year scan intervals). 25 age- sex-matched healthy normal controls (NC) also acquired at baseline 2 later same scanner as group. A total 874 from 339 participants NIH-funded study development intervals used an growth reference....
Background: Obesity may be a risk factor for developing multiple sclerosis (MS). Objective: We examined if body size influences the of MS in population-based, case control study. Methods: A total 953 cases and 1717 controls from Norway 707 1333 Italy reported their by choosing silhouette 1 to 9 (largest) every fifth year age 5 30 at time The size-related was defined odds ratios (ORs) logistic regression analyses adjusting age, smoking outdoor activity. Results: In large (silhouettes 6–9)...
Objectives: The objective of this paper is to estimate the association between multiple sclerosis (MS) and measures sun exposure in specific age periods Norway Italy. Methods: A total 1660 MS patients 3050 controls from Italy who participated a multinational case-control study (EnvIMS) reported habits during childhood adolescence. Results: significant infrequent summer outdoor activity increased risk was found strongest ages 16 18 years (odds ratio (OR) 1.83, 95% confidence interval (CI)...
Background: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age. Objective: The objective paper is to investigate the association between 3 supplementation through cod liver oil at different postnatal ages and MS risk. Methods: In Norwegian component multinational case-control study Environmental Factors Multiple Sclerosis (EnvIMS), a total 953 patients maximum disease duration 10...
The authors collected demographic, clinical, and neuroimaging data prospectively on 38 children with transverse myelitis. One child died during the illness. female:male ratio was 1.2:1 for under age 10 years 2.6:1 over years. Twenty-eight (74%) reported a prodromal event. Twenty-two patients (58%) had longitudinally extensive myelitis, 9 (24%) focal lesions, 5 (13%) both. Twenty of 33 brain imaging (61%) lesions; 7 fulfilled McDonald criteria dissemination in space. Seven 22 (36%) tested...
Multiple sclerosis (MS) in the pediatric age group is being increasingly recognized. In adults, complex interactions between genetic and environmental factors contribute to risk major component of MS susceptibility localizes histocompatibility (human leukocyte antigen [HLA]). Whether HLA alleles predict at-risk children presenting with acquired demyelinating syndromes (ADS) CNS unknown.HLA-DRB1 were typed using an allele-specific PCR amplification method on samples from 266 ADS enrolled...
For most adults with initial clinical presentation of multiple sclerosis (MS), biological disease was likely initiated many years prior. Pediatric-onset MS provides an opportunity to study early processes.Using antigen microarrays, including CNS-related proteins, lipids, and other autoantigens, we studied immunologic events involved in onset pediatric MS. Serum samples were collected at the time incident acquired CNS demyelinating syndromes (ADS) children who, subsequent prospective...
Several recent studies have found a higher risk of multiple sclerosis (MS) among people with low level education. This has been suggested to reflect an effect smoking and lower vitamin D status in the social class associated levels education.The objective this paper is investigate association between education MS adjusting for known factors smoking, infectious mononucleosis, indicators body size.Within case-control study on Environmental Factors In (EnvIMS), 953 patients 1717 healthy...
Background: Seasonal fluctuations in solar radiation and vitamin D levels could modulate the immune response against Epstein-Barr virus (EBV) infection influence subsequent risk of multiple sclerosis (MS). Methods: Altogether 1660 MS patients 3050 controls from Norway Italy participating multinational case-control study Environmental Factors In Multiple Sclerosis (EnvIMS) reported season past infectious mononucleosis (IM). Results: IM was generally more frequently ( p=0.002), but associated...
Background: Risk factors for aquaporin-4 (AQP4+) antibody neuromyelitis optica spectrum disorder (NMOSD) are not well-established. Objective: To investigate demographic and environmental associated with NMOSD using a validated questionnaire case–control design. Methods: We enrolled patients AQP4 + through six Canadian Multiple Sclerosis Clinics. Participants completed the Environmental Factors in Study (EnvIMS) questionnaire. Their responses were compared to those of 956 unaffected controls...
Abstract Objectives Children with medical complexity (CMC) are a population in need of policy and practice reform within the Canadian healthcare system. They generally characterized as sharing four predominant characteristics: (1) one or more complex chronic condition(s), (2) functional limitations, (3) high health resources use, (4) family-identified needs. There is currently no standard method to identify CMC Canada. The aim this research was establish clear select best way population....
Background: Results from previous studies on a possible interaction between smoking and Epstein–Barr virus (EBV) in the risk of multiple sclerosis (MS) are conflicting. Objectives: To examine infectious mononucleosis (IM) MS. Methods: Within case–control study Environmental Factors In Multiple Sclerosis (EnvIMS), 1904 MS patients 3694 population-based frequency-matched healthy controls Norway, Italy, Sweden reported prior exposure to history IM. We examined two exposures additive...
Multiple sclerosis (MS) is a chronic disease of the central nervous system, often resulting in significant neurological disability. The causes MS are not known; however, incidence increasing, thereby suggesting that changes lifestyle and/or environmental factors may be responsible. On this background, Environmental Risk Factors Study or EnvIMS study was designed to further explore etiology MS. design and methodology described, providing details enable investigators (i) use our experiences...
To describe the neonatal symptoms, developmental problems and chronic multisystem medical morbidities of congenital myotonic dystrophy (CDM) patients registered in United States National Registry Myotonic Dystrophy - a disease-specific, self-report program maintained since 2002. Comparisons with Canadian Paediatric Surveillance Program for CDM are highlighted.Genetically confirmed cases demonstrating symptoms first four weeks life described. Patients (or their caregivers) physicians...
Lower levels of sun exposure in childhood have been suggested to be associated with increased risk multiple sclerosis (MS). In this paper we extend previous work, using two novel analytical strategies.Data collected the Environmental factors MS (EnvIMS) study, a case-control study cases and population-based controls from Canada, Italy Norway, were used. Participants reported on behaviours for 5-year age intervals birth; focused first three (≤15 years). We compared life course epidemiology...
Chronic benzodiazepine receptor agonist (BZRA) use among older adults is a public health concern given cognitive and physical risks. One in four New Brunswick, Canada, long-term user of BZRAs. Previous studies using direct-to-patient approach as the primary intervention target have shown promise reducing BZRA use. The Your Answers When Needing Sleep Brunswick (YAWNS NB) study aims to reduce BZRAs increase behavioural therapy for insomnia (CBTi), which recommended first line treatment.The...
Decreasing research funding is in conflict with the increasing need to conduct large studies examine rare risk factors and interactions between factors. As a result, investigators are searching for strategies stretch funds design that will maximize investments already made. Multiple sclerosis (MS) generally accepted as multifactorial disease, assessment of desire assess within particular sub-groups requires number participants. Harmonization methodology may help address this problem....
Importance Direct-to-patient interventions enabling transitions from long-term benzodiazepine receptor agonist (BZRA) use to cognitive behavioral therapy for insomnia (CBTI) by older adults has the potential reduce BZRA and related harms while improving sleep outcomes without requiring prearranged clinician involvement. Objective To compare 2 direct-to-patient behavior change with treatment as usual (TAU) on use, sleep, other health outcomes, uptake of CBTI techniques. Design, Setting,...
A paralisia de Bell é uma facial unilateral início súbito e causa desconhecida. Pode afetar a salivação, o paladar lacrimejamento dependendo do topografia acometimento nervo facial, os pacientes podem referir hipersensibilidade auditiva. Nos com Bell, reflexo estapediano está ausente. OBJETIVO: O objetivo desta investigação foi verificar se apresentam hiperacusia. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram examinados 18 aleatórios apresentando periférica Bell. Foi...