A5031005426- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Infection Control and Ventilation
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Viral-associated cancers and disorders
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Parvovirus B19 Infection Studies
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Clostridium difficile and Clostridium perfringens research
- Infectious Encephalopathies and Encephalitis
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
McGill University
2013-2024
McGill University Health Centre
2020-2023
Google (United States)
2022
University of Calgary
2011-2021
Provincial Laboratory of Public Health
2009-2019
Alberta Health
2019
Alberta Health Services
2019
Queen's University
2017
Hospital for Sick Children
2003-2014
Public Health Agency of Canada
2013-2014
BackgroundSevere acute respiratory syndrome (SARS) is a condition of unknown cause that has recently been recognized in patients Asia, North America, and Europe. This report summarizes the initial epidemiologic findings, clinical description, diagnostic findings followed identification SARS Canada.MethodsSARS was first identified Canada early March 2003. We collected epidemiologic, clinical, data from each 10 cases prospectively as they were identified. Specimens all sent to local,...
Significance Lack of human data on influenza virus aerosol shedding fuels debate over the importance airborne transmission. We provide overwhelming evidence that humans generate infectious aerosols and quantitative to improve mathematical models transmission public health interventions. show sneezing is rare not important for—and coughing required for—influenza aerosolization. Our findings, upper lower airway infection are independent fine-particle exhaled reflect in lung, opened a pathway...
Abstract Avian influenza that infects poultry in close proximity to humans is a concern because of its pandemic potential. In 2004, an outbreak highly pathogenic avian H7N3 occurred British Columbia, Canada. Surveillance identified two persons with confirmed infection. Symptoms included conjunctivitis and mild influenzalike illness.
Building ventilation systems must get much better
A woman who recently traveled to Thailand came a local emergency department with fever and papular rash. She was tested for measles, malaria, dengue. Positive finding IgM antibody against dengue failure seroconvert IgG multiple blood samples suggested an alternate flavivirus etiology. Amplification of conserved region the non-structural protein 5 gene genus Flavivirus yielded polymerase chain reaction product matching sequence 99% identity Zika virus. urine sample nasopharygeal swab specimen...
Some infectious diseases, including COVID-19, can undergo airborne transmission. This may happen at close proximity, but as time indoors increases, infections occur in shared room air despite distancing. We propose two indicators of infection risk for this situation, that is, relative parameter (Hr) and (H). They combine the key factors control disease transmission indoors: virus-containing aerosol generation rate, breathing flow masking its quality, ventilation aerosol-removal rates, number...
If some countries lead by example, standards may increasingly become normalized.
In summer 2003, a respiratory outbreak was investigated in British Columbia, during which nucleic acid tests and serology unexpectedly indicated reactivity for severe acute syndrome coronavirus (SARS-CoV).Cases at care facility were epidemiologically characterized sequentially conventional agents of infection, SARS-CoV other human CoVs. Serological cross-reactivity between CoV-OC43 (HCoV-OC43) by peptide spot assay.Ninety-five 142 residents (67%) 53 160 staff members (33%) experienced...
The purpose of this study was to review the experience with herpes simplex encephalitis at Hospital for Sick Children over past 12 years.All patients who were admitted our institution acute between January 1994 and December 2005 enrolled prospectively in an registry. from registry included study; we detailed clinical presentations, laboratory findings, electroencephalographic diagnostic imaging treatments, outcomes all cases.Of 322 cases encephalitis, 5% caused by virus. Initially negative...
Many neurologic manifestations of Epstein-Barr virus (EBV) infection have been documented, including encephalitis, aseptic meningitis, transverse myelitis, and Guillain-Barré syndrome. These can occur alone or coincidentally with the clinical picture infectious mononucleosis. Since 1994, The Hospital for Sick Children has maintained a prospective registry all children admitted acute encephalitis. This report summarizes cases virus-associated encephalitis compiled from 1994 to 2003....
Abstract This is an account that should be heard of important struggle: the struggle a large group experts who came together at beginning COVID-19 pandemic to warn world about risk airborne transmission and consequences ignoring it. We alerted World Health Organization potential significance SARS-CoV-2 urgent need control it, but our concerns were dismissed. Here we describe how this happened consequences. hope by reporting story can raise awareness importance interdisciplinary collaboration...
Human adenoviruses are common pathogens associated with many diseases, including respiratory, gastrointestinal, and ocular infections. Because they now being increasingly recognized as agents of life-threatening disseminated infection in immunocompromised patients, robust sensitive laboratory detection methods needed for their rapid diagnosis. We describe here a PCR assay using single primer pair, targeting region the hexon gene containing hypervariable 7, that can detect all known human...
We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination. He had no prior evidence immune deficiency and history exposure or clinical disease. During hospitalization, primary immunodeficiency characterized by profoundly depressed CD8 cell count dysgammaglobulinemia was demonstrated. A brain biopsy revealed histopathologic features consistent with MIBE, antigens were detected...
The description and evaluation of a PCR-based assay for the detection species identification eight known human herpesviruses are presented. Two primer pairs targeting well-conserved regions genome allowed amplification DNAs all at high level sensitivity (10 to 100 copies most viruses). Identification virus was achieved through restriction enzyme digestion with Bam HI Bst UI, which yielded fragment sizes that were characteristic each herpesvirus. Furthermore, it demonstrated this panel...