A5083650444- Vitamin D Research Studies
- Multiple Sclerosis Research Studies
- Vitamin C and Antioxidants Research
- Adrenal Hormones and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Climate Change and Health Impacts
- Systemic Lupus Erythematosus Research
- Respiratory viral infections research
- Acne and Rosacea Treatments and Effects
- Morinda citrifolia extract uses
- Air Quality and Health Impacts
- Delphi Technique in Research
- Microscopic Colitis
- Psoriasis: Treatment and Pathogenesis
- Fatty Acid Research and Health
- Peripheral Neuropathies and Disorders
- Biotin and Related Studies
- Bone fractures and treatments
- Pituitary Gland Disorders and Treatments
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
SickKids Foundation
2010-2021
University of Toronto
2008-2021
Hospital for Sick Children
2010-2021
Public Health Ontario
2018
Murdoch Children's Research Institute
2016
Royal Children's Hospital
2016
UCSF Benioff Children's Hospital
2016
Erasmus University Rotterdam
2016
Erasmus MC
2016
University of Ferrara
2016
Abstract Background Vitamin D insufficiency has been implicated in autoimmunity. ChIP-seq experiments using immune cell lines have shown that vitamin receptor (VDR) binding sites are enriched near regions of the genome associated with autoimmune diseases. We aimed to investigate VDR primary CD4+ cells from healthy volunteers. Methods extracted nine Each sample underwent ChIP-seq. Our results were analyzed relation published and RNA-seq data Genomic HyperBrowser. used MEMEChIP for de novo...
Background: For reasons that remain unclear, three times more women develop multiple sclerosis (MS) than men. This preponderance among is evident only after 12 years of age, implicating pubertal factors in the risk MS. Objective: To investigate influence female puberty on central nervous system (CNS) autoimmunity. Methods: We examined relationship between age menarche MS outcomes 116 children (< 16 old) whom presented with incident ‘acquired demyelinating syndromes’ (ADS) and were...
Background: There is a well-documented increase in the risk of multiple sclerosis (MS) when migrating from region low prevalence to one high prevalence. Objective: We present here an investigation MS and candidate environmental genetic factors among Iranian immigrants British Columbia (BC), Canada. Methods: cases ancestry were ascertained population-based Canadian study. collected blood samples for serological analyses, administered personal history questionnaire cases. Results: The crude...
Pomiferin and osajin are prenylated isoflavones from Osage orange fruit that both have potent antioxidant activity in a variety of assays. Pomiferin, particular, has strong against the superoxide anion photochemiluminescence (PCL) assay system. In vitro, pomiferin, but not osajin, demonstrated selective antiproliferative tumorigenic breast epithelial cell line MCF-7 (IC(50) = 5.2 μM) with limited toxicity toward nontumorigenic cells (MCF-10A). The differential sensitivity normal to action...
Physiological and lifestyle factors put older adults at an increased risk of vitamin D insufficiency resulting negative health outcomes. Here we explore the status in a sample community dwelling diverse ancestry living Greater Toronto area (GTA).Two hundred twenty-four (224) over 60 years age were recruited from Square One Older Adult Centre, Mississauga, Ontario. Circulating 25-hydroxyvitamin (25(OH)D) concentrations measured dried blood spot cards. Dietary supplemental intakes assessed via...
Background: Being obese is associated with both increased risk of developing multiple sclerosis (MS) and greater MS disease activity. Objectives: The objective this study to investigate levels potential pathophysiologic contribution serum adipose-hormones (adipokines) in pediatric-onset MS. Methods: Following a Luminex adipokine screen, adiponectin (APN) its isoforms were quantified by enzyme-linked immunosorbent assay (ELISA) 169 children incident acquired demyelinating syndromes (ADS),...
OBJECTIVE: To determine whether body mass index (BMI) at diagnosis of pediatric-onset multiple sclerosis (MS) predicts disease activity, including annualized relapse rate (ARR) and new MRI lesions. BACKGROUND: Obesity in childhood adolescence has been shown to be a risk factor for developing MS, particularly amongst females. It is not known obesity modifies course established MS. Animal studies suggest an association between inflammation, with leptin promoting pro-inflammatory T cells...
Background: While studying the etiology of multiple sclerosis (MS) in children has several methodological advantages over adults, studies are limited by small sample sizes. Objective: Using a rigorous process, we developed Pediatric MS Tool-Kit, measurement framework that includes minimal set core variables to assess etiological risk factors. Methods: We solicited input from International Study Group select three factors: environmental tobacco smoke (ETS) exposure, sun and vitamin D intake....
Regarding the recent article by Shaygannejad et al. [1], we are writing to express serious concerns about portrayal of intervention and authors' interpretation discussion findings. Of predominate concern is that authors utilized a calcitriol in their study but referred it as “vitamin D”. The erroneous use term D” for several reasons. Firstly, vitamin D biologically inactive form can be synthesized skin when exposed ultraviolet B radiation found foods. In order produce active metabolite,...
Overview Vitamin D has been implicated in risk of autoimmune diseases including multiple sclerosis (MS). Children presenting with initial acquired demyelinating syndromes (ADS) are at high subsequent MS diagnosis and thus, provide an opportunity to explore vitamin as a determinant risk. Objective We sought determine whether serum 25‐hydroxyvitamin [25(OH)D] pediatric ADS presentation is predictive diagnosis. Methods Incident cases were enrolled national prospective study. Serum collected...