A5085944586- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Cell Image Analysis Techniques
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- EEG and Brain-Computer Interfaces
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
Uppsala University Hospital
2016-2021
Shaanxi Normal University
2018
Uppsala University
2016-2018
OBJECTIVE Magnetic resonance imaging tends to underestimate the extent of diffuse low-grade gliomas (DLGGs). With aim studying presence tumor cells outside radiological border, authors developed a method correlating MRI findings with histological data in patients suspected DLGGs whom en bloc resections were performed. METHODS Five DLGG suitable for resection recruited from an ongoing prospective study. Sections entire immunostained antibodies against mutated IDH1 protein (IDH1-R132H). images...
Vascular gene expression patterns in lower-grade gliomas (LGGs; diffuse World Health Organization [WHO] grades II-III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH) mutation status affects vascular phenotype.Gene analyzed using an in-house dataset derived from microdissected total samples human glioma combination with data 289 available the database Cancer Genome Atlas....
Oligodendrogliomas are heterogeneous tumors in terms of imaging appearance, and a deeper understanding the histopathological tumor characteristics correlation to parameters is needed. We used PET-to-MRI-to-histology co-registration with aim studying intra-tumoral 11C-methionine (MET) uptake relation perfusion protein expression histological cell markers corresponding areas. Consecutive sections four covering entire en bloc-removed were immunostained antibodies against IDH1-mutated (tumor...
PROX1 is a transcription factor with an essential role in embryonic development and determination of cell fate. In addition, has been ascribed suppressive as well oncogenic roles several human cancers, including brain tumors. this study we explored the correlation between expression patient survival high-grade astrocytomas. For purpose, analyzed protein tissue microarrays tumor samples stratified by age IDH mutation status. We initially screened 86 unselected astrocytomas, followed 174...
Background: Biological causes of sex disparity seen in the prevalence cancer, including glioblastoma (GBM), remain poorly understood. One considered aspects is involvement chromosomes, especially loss chromosome Y (LOY). Methods: Tumors from 105 isocitrate dehydrogenase (IDH) wild type male GBM patients were tested with droplet digital PCR for copy number changes ten genes on Y. Decreased gene expression, a proxy loss, was then analyzed 225 IDH derived TCGA and overall survival both cohorts...
Ecstatic seizures constitute a rare form of epilepsy, and the semiology is diverse. Previously, brain areas including temporal lobe insula have been identified to be involved in clinical expression. The aim this report review changes ecstatic patient before after operation hypothalamic hamartoma, scrutinize relation gelastic seizures. In case, disappeared surgery hamartoma but reappeared eleven years later. Clinical information was retrospectively obtained from medical records, interviews,...
Ecstatic seizures constitute a rare form of epilepsy, and the semiology is diverse. Previously, brain areas including temporal lobe insula have been identified to be involved in clinical expression. The aim this report review changes ecstatic patient before after operation for hypothalamic hamartoma, scrutinize relation gelastic seizures. In case, disappeared surgery hamartoma but reappeared eleven years later. Clinical information was retrospectively obtained from medical records,...
Abstract BACKGROUND Apart from few exceptions, men are more likely to be diagnosed with cancer during their lifetime, including glioblastoma (GBM), but the gender-related differences in GBM poorly understood. Loss of chromosome Y (LOY) peripheral blood cells is associated physiological ageing, also disorders like cardiovascular disease, Alzheimer’s disease and different types. In this study, we determined deletions on tumor tissue male patients GBM, studied impact LOY survival. MATERIAL AND...