A5087378198- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Diet and metabolism studies
- Traumatic Brain Injury Research
- Neurofibromatosis and Schwannoma Cases
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Fractures and Fixation Techniques
Uppsala University
2016-2025
Uppsala University Hospital
2015-2025
Institute of Neurological Sciences
2014-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2018
CHI St. Vincent
2015
University of Ferrara
2010-2014
Medical Education Institute
2014
Anna University, Chennai
2013-2014
Ospedale Sant'Anna
2014
OBJECTIVE Magnetic resonance imaging tends to underestimate the extent of diffuse low-grade gliomas (DLGGs). With aim studying presence tumor cells outside radiological border, authors developed a method correlating MRI findings with histological data in patients suspected DLGGs whom en bloc resections were performed. METHODS Five DLGG suitable for resection recruited from an ongoing prospective study. Sections entire immunostained antibodies against mutated IDH1 protein (IDH1-R132H). images...
Abstract Background The postoperative course after surgery for primary brain tumours can be difficult to predict. We examined the time of neurological deficits and analysed possible predisposing factors. Method Hundred adults with a radiological suspicion low- or high-grade glioma were prospectively included analysed. Possible predictors deterioration evaluated. Results New neurologic occurred in 37% patients, 4%, there worsening preoperative deficit. In 78%, directly surgery. probable cause...
Since the introduction of molecular definition oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and 1p19q-codeletion, it has become increasingly evident how this glioma entity differs much from other diffuse lower grade gliomas stands out with longer survival often better responsiveness to adjuvant therapy. Therefore, apart using a oligodendroglioma definition, an extended follow-up time is necessary understand nature slow growing, yet malignant condition. The aim study was...
The middle longitudinal fascicle (MdLF) is a long, associative white matter tract connecting the superior temporal gyrus (STG) with parietal and occipital lobe. Previous studies show different cortical terminations, possible segmentation pattern of tract. In this study, we performed post-mortem dissection 12 human hemispheres an in vivo deterministic fiber tracking 24 subjects acquired from Human Connectome Project to establish whether constant organization fibers exists among MdLF...
Expression and release of nociceptin/orphanin FQ (N/OFQ) are elevated in the substantia nigra reticulata 6-hydroxydopamine-hemilesioned rats, suggesting a pathogenic role for N/OFQ Parkinson's disease. In this study, we investigated whether elevation expression rats selectively occurs hypomotility following acute haloperidol administration is accompanied by rise nigral levels. Moreover, to prove link between idiopathic disease humans, measured levels cerebrospinal fluid parkinsonian patients...
Diffuse low-grade gliomas (DLGG) display different preferential locations in eloquent and secondary associative brain areas. The reason for this tendency is still unknown. We hypothesized that the intrinsic architecture water diffusion properties of white matter bundles these regions may facilitate infiltration. Magnetic resonance imaging sixty-seven diffuse patients were normalized to/and segmented MNI space to create three probabilistic infiltration weighted gradient maps according...
Abstract Purpose Adult patients with diffuse lower-grade gliomas (dLGG) show heterogeneous survival outcomes, complicating postoperative treatment planning. Treating all early increases the risk of long-term side effects, while delayed may lead to impaired survival. Refinement prognostic models could optimize timing treatment. Conventional radiological features are in dLGG, but MRI carry more information. This study aimed investigate MRI-based radiomics and compare them clinical models....
Olfaction is in many ways the least understood sensory modality. Its organization and connectivity are still under debate. The aim of this study was to investigate anatomy olfactory system by using a cadaver fiber dissection technique vivo tractography attain deeper understanding subcortical organization. Ten cerebral hemispheres were used for white matter according Klingler's technique. Measurements different cortical structures interhemispheric symmetry compared. Diffusion tensor imaging...
ABSTRACT Intro Seizure incidence in diffuse glioma ranges between 60% and 90%. This study aimed to investigate the association seizures subcortical cortical brain regions, including white matter tracts. Methods Adult patients with at Uppsala University Hospital from 2005 2021 were analysed retrospectively. The relationship tumour location specific voxels preoperative was examined concerning tract involvement. Tumour volumes segmented based on T2‐weighted or FLAIR MRI after spatial...
Abstract Background Visual snow syndrome (VSS) is a neurological condition characterized by flickering dots throughout the entire visual field. Both pathophysiology and possible location of VSS are still under debate. White matter abnormalities were investigated using diffusion tensor imaging (DTI) in patient with VSS. Methods A 28‐year‐old 10 healthy controls DTI. Diffusion parametric maps calculated reconstructed q‐space diffeomorphic reconstruction. pathways dorsal, ventral, integrative...
Abstract Tertiary lymphoid structures (TLS) are ectopic aggregates associated with improved prognosis in numerous tumors. To date, their prognostic value central nervous system cancers and the events underlying formation remain unclear. Here, we find that TLS correlate survival glioblastoma patients. Furthermore, combining spatial transcriptomics of human tissues longitudinal studies murine glioma, establish assembly T cell-rich clusters is a prerequisite for development canonical TLS, show...
The transcavernous approach adds a significant exposure advantage in basilar aneurysm surgery. However, one of its frequently reported side effects is postoperative oculomotor nerve palsy.To present the technique mobilizing throughout intracranial course and to analyze consequences on tension clinical outcome.The mobilized from mesencephalic origin superior orbital fissure. Its degree mobility, related imposed pulling force, was measured 11 cadaveric nerves. Tension mathematically deduced...
<i>Introduction:</i> Globus pallidus internus (GPi) deep brain stimulation (DBS) represents a validated, effective, and safe treatment for patients affected by generalized dystonia resistant to conservative treatment. Segmental multisegmental have more recently been proposed as further indications GPi DBS despite the lack of long-term homogenous follow-up. Here we present an original detailed follow-up (5 years) homogeneous population 11 segmental or dystonia. <i>Materials...