A5045007831- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Epilepsy research and treatment
- Neurological disorders and treatments
- Brain Metastases and Treatment
- Anatomy and Medical Technology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- MRI in cancer diagnosis
- Neurobiology of Language and Bilingualism
- Brain Tumor Detection and Classification
- Musculoskeletal pain and rehabilitation
- Dental Radiography and Imaging
- Anesthesia and Pain Management
- Transcranial Magnetic Stimulation Studies
- Advanced Electron Microscopy Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Nanoplatforms for cancer theranostics
- Spinal Fractures and Fixation Techniques
Karolinska University Hospital
2018-2025
Karolinska Institutet
2018-2025
Rigshospitalet
2018-2025
Brainlab (Germany)
2024
Copenhagen University Hospital
2018
National University Hospital of Iceland
2006
Since the introduction of molecular definition oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and 1p19q-codeletion, it has become increasingly evident how this glioma entity differs much from other diffuse lower grade gliomas stands out with longer survival often better responsiveness to adjuvant therapy. Therefore, apart using a oligodendroglioma definition, an extended follow-up time is necessary understand nature slow growing, yet malignant condition. The aim study was...
Abstract Purpose Adult patients with diffuse lower-grade gliomas (dLGG) show heterogeneous survival outcomes, complicating postoperative treatment planning. Treating all early increases the risk of long-term side effects, while delayed may lead to impaired survival. Refinement prognostic models could optimize timing treatment. Conventional radiological features are in dLGG, but MRI carry more information. This study aimed investigate MRI-based radiomics and compare them clinical models....
Knowledge about the long-term outcome of high-level language ability in awake surgery patients with low-grade gliomas or cavernomas eloquent regions is limited, particularly regarding subtle changes abilities. The study group consisted 27 LGG cavernoma which involved left hemisphere. A comprehensive assessment battery was used to target overall as well sub skills. Assessments were made preoperatively and at 3 12 months postoperatively. results showed that had not decreased significantly...
Glioma is the most common intra-axial tumor, and its location relative to critical areas of brain important for treatment decision-making. Studies often report tumor based on anatomical taxonomy alone since estimation eloquent regions requires considerable knowledge functional neuroanatomy is, some degree, a subjective measure. An unbiased reproducible method determine eloquence desirable, both clinical use research purposes.To voxel-based assessing distribution proximity in diffuse...
Abstract Background Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy selected “high-risk” patients. Still, there are number controversies related to DLGG management. The objective this multicenter population-based cohort study was explore potential variations diagnostic work-up between treating centers 2 Scandinavian countries with similar public health care...
Laser interstitial thermal therapy (LITT) is a stereotactic neurosurgical procedure used to treat neoplastic and epileptogenic lesions in the brain. A variety of advanced technological instruments such as frameless navigation systems, robotics, intraoperative MRI are often described this context, although surgical can also be performed using standard setup diagnostic suite.We report on our experience technique Leksell frame suite perform LITT.LITT safely suite, making available even...
Abstract BACKGROUND AND IMPORTANCE Stereotactic brain biopsy (SB) is an important part of the neurosurgical armamentarium, with possibility achieving histopathological diagnosis in otherwise inaccessible lesions brain. Nevertheless, procedure not without risk morbidity, which especially true for eloquent parts brain, where even a minor adverse event can result significant deficits. Navigated transcranial magnetic stimulation (nTMS) widely used to chart areas, successfully guiding maximal...
Intraoperative MRI (iMRI) has emerged as a useful tool in glioma surgery to safely improve the extent of resection. However, iMRI requires dedicated operating room (OR) with an integrated scanner solely for this purpose. Due physical or economical restraints, may not be feasible all centers. The aim study was investigate feasibility using non-dedicated at radiology department and describe workflow special focus on time expenditure surgical implications.
<title>Abstract</title> Objective The precision of neuronavigation systems relies on the correct registration patient’s position in space and aligning it with radiological 3D imaging data. Registration is usually performed by acquisition anatomical landmarks or surface matching based facial features. Another possibility automatic image using intraoperative imaging. This could provide better accuracy especially rotated prone positions where other methods may be difficult to perform. aim this...
Objective: The precision of neuronavigation systems relies on the correct registration patient’s position in space and aligning it with radiological 3D imaging data. Registration is usually performed by acquisition anatomical landmarks or surface matching based facial features. Another possibility automatic image using intraoperative imaging. This could provide better accuracy, especially rotated prone positions where other methods may be difficult to perform. aim this study was validate...
Abstract Emerging research suggests that failure to target glioma stem cells (GSCs) rather than the inability remove tumors through surgery, radiation, or chemotherapy, explains poor survival of GBM patients. In this study, a luminescent conjugated oligothiophene (LCO), named GlioStem (p-HTMI), is used for non-invasive and non-amplified real-time detection GSCs in live human GBM-tissue. More 90 patient samples were stained, quantified, analyzed by fluorescent microscopy presence...