Nicola Limbucci
A5059043728- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Long-Term Effects of COVID-19
- Aortic Disease and Treatment Approaches
- Spine and Intervertebral Disc Pathology
- Infectious Encephalopathies and Encephalitis
- Musculoskeletal pain and rehabilitation
- Moyamoya disease diagnosis and treatment
- Retinal and Optic Conditions
- Kawasaki Disease and Coronary Complications
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Multiple Sclerosis Research Studies
- Vascular Malformations and Hemangiomas
University of Florence
2017-2025
Azienda Ospedaliero-Universitaria Careggi
2016-2025
NewYork–Presbyterian Hospital
2024-2025
Cornell University
2024-2025
New York Hospital Queens
2024-2025
Presbyterian Hospital
2024-2025
Policlinico Umberto I
2024
Sapienza University of Rome
2024
Brigham and Women's Hospital
2022
Azienda di Rilievo Nazionale ed Alta Specializzazione
2022
To prospectively compare the clinical effectiveness of intraforaminal and intradiscal injections a mixture steroid, local anesthetic, oxygen-ozone (O(2)-O(3)) (chemodiscolysis) versus steroid an anesthetic in management radicular pain related to acute lumbar disk herniation.Medical Ethical Committee approval informed consent were obtained. One hundred fifty-nine patients (86 men, 73 women; age range, 18-71 years) included randomly assigned two groups. Seventy-seven (group A) underwent 82 B)...
OBJECTIVE Flow diversion for posterior circulation aneurysms performed using the Pipeline embolization device (PED) constitutes an increasingly common off-label use otherwise untreatable aneurysms. The safety and efficacy of this treatment modality has not been assessed in a multicenter study. METHODS A retrospective review prospectively maintained databases at 8 academic institutions was years 2009 to 2016 identify patients with treated PED placement. RESULTS total 129 consecutive underwent...
The management of acute ischemic stroke is changing. Over the period 2010-2050, number incident strokes expected to be more than double. Rapid access mechanical thrombectomy for patients with large vessel occlusion critically associated their functional outcome. Moreover, first pass effect had a better clinical outcome, lower mortality, and fewer procedural adverse events. We discuss some advances in regarding organization, diagnosis treatment.
Background Flow-diverter stents (FDS) have become the standard of care for a wide range intracranial aneurysms, but their efficacy/safety in context recurrent/recanalized aneurysms following stent-assisted coiling (SAC) is not well established. We evaluate outcomes FDS retreatment large multicenter cohort. Methods retrospectively analyzed data from 118 patients across 22 institutions who underwent recurrent/persistent after SAC (2008–22). The primary outcome was angiographic occlusion status...
Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed nomogram predicting in patients with large vessel occlusion anterior circulation who received bridging intravenous thrombolysis (training set), validate model by using cohort treated direct (test set). Methods— We conducted study on prospectively collected data from 3714 enrolled IER (Italian Registry...
In patients with acute ischemic stroke treated reperfusion therapy we aimed to evaluate whether pretreatment blood-brain barrier (BBB) leakage is associated subsequent hemorrhagic transformation (HT).We prospectively screened intravenous thrombolysis and/or endovascular treatment. Before treatment, each patient received computed tomography (CT), CT angiography, and perfusion. We assessed BBB within the area using volume transfer constant (Ktrans ) value. Our primary outcome was relevant HT,...
During the coronavirus disease 2019 (COVID-19) pandemic, World Health Organization recommended measures to mitigate outbreak such as social distancing and confinement. Since these have been put in place, anecdotal reports describe a decrease number of endovascular therapy (EVT) treatments for acute ischemic stroke due large vessel occlusion. The purpose our study was determine effect on EVT patients with during COVID-19 In this retrospective, observational study, data were collected from...
<h3>BACKGROUND AND PURPOSE:</h3> Successful vessel recanalization in posterior circulation large-vessel occlusion is considered crucial, though the evidence of clinical usefulness, compared with anterior circulation, not still determined. The aim this study was to evaluate predictors favorable outcome and analyze effect first-pass thrombectomy. <h3>MATERIALS METHODS:</h3> A retrospective, multicenter, observational conducted 10 high-volume stroke centers Europe, including period from January...
Vessel perforation during thrombectomy is a severe complication and hypothesized to be more frequent medium vessel occlusion (MeVO) thrombectomy. The aim of this study was compare the incidence outcome patients with MeVO large (LVO) report on procedural steps that led perforation.
Background The Woven EndoBridge (WEB) device is frequently used for the treatment of intracranial aneurysms. Postoperative management, including use aspirin, varies among clinicians and institutions, but its impact on outcomes WEB has not been thoroughly investigated. Methods This was a retrospective, multicenter study involving 30 academic institutions in North America, South Europe. Data from 1492 patients treated with were included. Patients categorized into two groups based their...
Background Y-stent assisted coiling has been proposed for the treatment of wide-neck bifurcation aneurysms, but there are many technical variations. We report our single-center experience aneurysms with closed cell Enterprise stent in order to evaluate safety and long-term results this technique. The literature on Y-stenting its hemodynamic effects reviewed. Methods Fifty-two consecutive patients underwent two stents. procedure was completed 48 cases (92.3%) failure occurred 4 (7.3%). Cases...
<h3>SUMMARY:</h3> Brain AVMs are a rare cause of cerebral hemorrhage and SAH, their treatment is still debated. The aim this study was to describe novel endovascular approach with transvenous embolization deep hemorrhagic brain AVMs. Five patients (3 females, 2 males; mean age, 33.2 years) underwent AVM at our institution between February April 2012. Clinical angiographic data the end procedure after 6 months reported. All were completely obliterated, no intra- or postprocedural...
Background and purpose Assisted coiling with stents or balloons enables a higher percentage of complete occlusions saccular unruptured intracranial aneurysms to be achieved reasonable complication rate. The aim this study was compare stent-assisted the balloon remodeling technique in terms efficacy, stability, safety for treatment comparable aneurysms. Materials methods 268 patients 286 wide-necked were treated at our institution stent- balloon-assisted retrospectively reviewed. Statistical...
Background and Purpose- The benefit of endovascular therapy in extended time windows has been demonstrated patients with anterior circulation large vessel occlusion ischemic stroke favorable imaging profile. We evaluated whether collaterals thrombus burden influence the associations between revascularization, time-to-treatment, outcome therapy-treated basilar artery occlusion. Methods- retrospectively analyzed clinical data consecutive included multicenter Basilar Artery Treatment Management...
There are limited data concerning procedure-related complications of endovascular thrombectomy for large vessel occlusion strokes.We evaluated the cumulative incidence, clinical relevance in terms increased disability and mortality, risk factors complications.From January 2011 to December 2017, 4799 patients were enrolled by 36 centers Italian Registry Endovascular Stroke Treatment. Data on demographic procedural characteristics, complications, outcome at three months prospectively...
Abstract BACKGROUND While there are reports of acute ischemic stroke (AIS) in coronavirus disease 2019 (COVID-19) patients, the overall incidence AIS and clinical characteristics large vessel occlusion (LVO) remain unclear. OBJECTIVE To attempt to establish COVID-19 patients an international cohort. METHODS A cross-sectional retrospective, multicenter study consecutive admitted with was undertaken from March 1 May 1, 2020 at 12 centers 4 countries. Out those centers, 9 all types strokes data...
The objective of this paper was to explore the utility time maximum concentration (Tmax )-based target mismatch on computed tomography perfusion (CTP) in predicting radiological and clinical outcomes patients with acute ischemic stroke (AIS) anterior circulation large vessel occlusion (LVO) selected for endovascular treatment (EVT).Patients AIS underwent CTP within 24 hours from onset followed by EVT. Critically hypoperfused tissue core volumes were automatically calculated using Tmax...
The purpose of this study was to evaluate the effectiveness mechanical thrombectomy (MT) in patients with isolated M2 occlusion and minor symptoms identify possible baseline predictors clinical outcome.The databases 16 high-volume stroke centers were retrospectively screened for consecutive a National Institutes Health Stroke Scale (NIHSS) score ≤5 who received either early MT (eMT) or best medical management (BMM) possibility rescue (rMT) on neurological worsening. Because our not...
Patients with minor stroke and M2 occlusion undergoing best medical management (BMM) may face early neurological deterioration (END) that can lead to poor long-term outcome. In case of END, rescue mechanical thrombectomy (rMT) seems beneficial. Our study aimed define factors relevant clinical outcome in patients BMM the possibility rMT on find predictors END.Patients a baseline National Institutes Health Stroke Scale (NIHSS) score≤5 received either only or END after were extracted from...