A5102783938- Advanced MRI Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Advanced NMR Techniques and Applications
- Iron Metabolism and Disorders
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Electron Spin Resonance Studies
- Systemic Sclerosis and Related Diseases
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- NMR spectroscopy and applications
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Ultrasound and Hyperthermia Applications
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Electromagnetic Fields and Biological Effects
- Trace Elements in Health
- Hepatitis C virus research
- Muscle activation and electromyography studies
- Electrical and Bioimpedance Tomography
Regione Toscana
2013-2022
Fondazione Toscana Gabriele Monasterio
2013-2022
National Research Council
2006-2022
University of Florence
2013-2020
Ospedale di Livorno
2020
Terra
2020
Istituto di Fisiologia Clinica
2005-2014
National Academies of Sciences, Engineering, and Medicine
2013
University of Pisa
2008
Czech Academy of Sciences, Institute of Physiology
2006-2007
Abstract Purpose To assess the tissue iron concentration of left ventricle (LV) using a multislice, multiecho T2* MR technique and segmental analysis. Materials Methods MRI was performed in 53 thalassemia major patients. Three short‐axis views LV were obtained analyzed with custom‐written software. The myocardium automatically segmented into 12 segments. value on each segment as well global calculated. Cine dynamic images also to evaluate biventricular function parameters by quantitative...
Abstract Purpose To assess the transferability of magnetic resonance imaging (MRI) multislice multiecho T2* technique for global and segmental measurement iron overload in thalassemia patients. Materials Methods Multiecho sequences were installed on six MRI scanners. Five healthy subjects ( n = 30) scanned at each site; five major (TM) patients reference site rescanned locally 25) within 1 month. images analyzed using previously validated software. Results values showed intersite...
Cardiovascular magnetic resonance (CMR) has dramatically changed the clinical practice in thalassemia major (TM), lowering cardiac complications. We prospectively reassessed predictive value of CMR parameters for heart failure (HF) and arrhythmias TM.We considered 481 white TM patients (29.48 ± 8.93 years, 263 females) enrolled Myocardial Iron Overload Thalassemia (MIOT) network. liver iron overload were measured by T2* multiecho technique. Atrial dimensions biventricular function quantified...
Abstract A segmental, multislice, multi‐echo T 2 * MRI approach could be useful in heart iron‐overloaded patients to account for heterogeneous iron distribution, demonstrated by histological studies. However, segmental assessment can affected the presence of geometrical and susceptibility artefacts, which act on different segments ways. The aim this study was assess value distribution left ventricle develop a correction procedure compensate artefactual variations analysis. performed four...
Mild-to-moderate hypertension is often associated with insulin resistance and visceral adiposity. Whether these metabolic abnormalities have an independent impact on regional cardiac function not known. The goal of this study was to investigate the effects increased blood pressure, resistance, ectopic fat accumulation changes in peak systolic circumferential strain. Thirty-five male subjects (age: 47+/-1 years; body mass index: 28.4+/-0.6 kg m(-2); mean+/-SEM) included 13 normal pressure...
Abstract: Objectives: Oral deferiprone (L1) appears to be promising in the treatment of β ‐thalassemia major (TM) patients. T2* magnetic resonance imaging (MRI) with a single measurement mid‐ventricular septum was validated as quantitative evaluation myocardial iron overload. Previous studies suggested marked heterogeneity distribution myocardium. We set up multislice multiecho MRI for detection this heterogeneity. The aim our study investigate differences between L1 vs. subcutaneous...
Diabet. Med. 29, 622–627 (2012) Abstract Objective Previous studies have highlighted the associations between abdominal, cardiac or total fat accumulation and cardiovascular disease. The aim of this study was to investigate impact different ectopic depots on measurements metabolic dysfunction disease risk. Methods Using magnetic resonance imaging in 113 subjects, we measured abdominal (visceral subcutaneous) (epicardial extra‐pericardial) examined their association with overall (BMI) obesity...
Abstract Purpose To evaluate the effectiveness of single ROI approach for detection hepatic iron burden in thalassemia major (TM) patients respect to a whole liver measurement. Materials and Methods Five transverse slices were acquired by T2* gradient‐echo sequence 101 TM 20 healthy subjects. The value was calculated region interest (ROI) defined medium‐hepatic slice. Moreover, extracted on each eight ROIs functionally independent segments. mean calculated. Results For patients, values over...
Systemic sclerosis (SSc) may induce cardiac fibrosis and systo-diastolic dysfunction. Cardiovascular magnetic resonance (CMR) can detect replacement myocardial with late gadolinium enhancement (LGE) interstitial T1 mapping techniques. The aim of the study was to subclinical involvement CMR in paucisymptomatic SSc patients no previous history disease, comparing it skeletal muscle remodelling.Thirty consecutive (mean age: 51 ± 12 years, all women) 10 healthy controls 48 15 underwent clinical,...
Cardiac rhythm disturbances constitute the most frequent cardiovascular cause of death in SSc. However, electrocardiographic findings are not a part risk stratification We aimed to translate 24 h Holter into tangible prediction score using magnetic resonance.
<b><i>Objective:</i></b> To verify incidence rates and their temporal trend in a homogeneous, ethnically, genetically distinct population of central Sardinia (the Nuoro province). <b><i>Background:</i></b> Intensive epidemiologic studies carried out since the 1970s have suggested that prevalence MS are much higher this Mediterranean island compared with those found on mainland Italy. <b><i>Methods:</i></b> The study area had approximately 274,000 people 1991 census. authors adopted complete...
Abstract This study aimed to determine the feasibility, reproducibility, and reliability of multiecho T * 2 Magnetic resonance imaging technique at 3 for myocardial liver iron burden quantification relationship between values 1.5 T. Thirty‐eight transfusion‐dependent patients 20 healthy subjects were studied. Cardiac segmental global calculated after developing a correction map compensate artifactual variations. The hepatic value was determined over region interest. intraoperator...
Human neuropathological studies indicate that the pontine nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's disease. This line of evidence alongside experimental data suggests LC functional/structural decay may represent a critical factor for disease pathophysiological clinical progression. In present prospective study, we used Magnetic Resonance Imaging (MRI) with LC-sensitive sequence (LC-MRI) to investigate vivo involvement progression, whether...
Increased glucose utilization and regional differences in contractile function are well-known alterations of the failing heart play an important pathophysiological role. We tested whether, similar to functional derangement, changes uptake develop following a pattern. Heart failure was induced 13 chronically instrumented minipigs by pacing left ventricular (LV) free wall at 180 beats/min for 3 wk. Regional stress were assessed magnetic resonance imaging, whereas flow measured positron...
Abstract The present study investigated myocardial T2* heterogeneity in thalassaemia major (TM) patients by cardiac magnetic resonance (CMR), to determine whether is related inhomogeneous iron overload distribution. A total of 230 TM consecutively referred our laboratory were studied retrospectively. Three short‐axis views (basal, medium and apical) the left ventricle (LV) obtained multislice multiecho CMR. segmental distribution was mapped on a 16‐segment LV model. level distribution,...