A5069086884- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Migraine and Headache Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Health, Environment, Cognitive Aging
- Neurological disorders and treatments
- Neurological Disorders and Treatments
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Prion Diseases and Protein Misfolding
- Advanced MRI Techniques and Applications
- Statistical Methods in Clinical Trials
- Trigeminal Neuralgia and Treatments
- Amyotrophic Lateral Sclerosis Research
- Health Systems, Economic Evaluations, Quality of Life
Pitié-Salpêtrière Hospital
2018-2024
Assistance Publique – Hôpitaux de Paris
2018-2024
Sorbonne Université
2018-2024
Inserm
2018-2024
Alzheimer Precision Medicine
2018-2024
Centre National de la Recherche Scientifique
2018-2024
GTx (United States)
2024
Centre d'Acquisition et de Traitement des Images
2024
Laboratoire d’Imagerie Biomédicale
2022-2024
Angelini Pharma (Italy)
2024
Abstract Introduction Blood‐based biomarkers of pathophysiological brain amyloid β (Aβ) accumulation, particularly for preclinical target and large‐scale interventions, are warranted to effectively enrich Alzheimer's disease clinical trials management. Methods We investigated whether plasma concentrations the Aβ 1–40 /Aβ 1–42 ratio, assessed using single‐molecule array (Simoa) immunoassay, may predict positron emission tomography status in a longitudinal monocentric cohort (N = 276) older...
The current study aimed at establishing the prevalence of impulse control disorders (ICDs) in patients with Parkinson disease (PD) and their association demographic, drug-related, disease-related characteristics. We performed a single-center cross-sectional 805 PD patients. Impulse were investigated Questionnaire for Impulsive Compulsive Disorders Parkinson's Disease; also comorbid neuropsychiatric complications (dementia, delusions, visual hallucinations) clinical interviews ad hoc...
Abstract Introduction The longitudinal trajectories of functional brain dynamics and the impact genetic risk factors in individuals at for Alzheimer's disease are poorly understood. Methods In a large‐scale monocentric cohort 224 amyloid stratified disease, default mode network (DMN) resting state connectivity (FC) was investigated between two serial time points across 2 years. Results Widespread DMN FC changes were shown frontal posterior areas, as well right hippocampus. There no...