A5081303009- Dementia and Cognitive Impairment Research
- Down syndrome and intellectual disability research
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Metabolomics and Mass Spectrometry Studies
- Functional Brain Connectivity Studies
- Chronic Disease Management Strategies
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Spatial Neglect and Hemispheric Dysfunction
- Diet and metabolism studies
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Cardiovascular Health and Risk Factors
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Gut microbiota and health
- Neurological Disorders and Treatments
University of California, Irvine
2016-2025
University of California System
2024
Northwestern University
1998-2023
Centre National de la Recherche Scientifique
2019
Assistance Publique – Hôpitaux de Paris
2019
Pitié-Salpêtrière Hospital
2019
Sorbonne Université
2019
Inserm
2019
Alzheimer Precision Medicine
2019
Irvine University
2019
Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Methods Blood obtained at one time-point patients with AD (n = 57) or frontotemporal dementia (FTD) 16), two time-points others 24) when cognitively normal 1 10 years later diagnosed enriched neural sources by immunoabsorption. AD-pathogenic exosomal proteins enzyme-linked immunosorbent assays. Results Mean levels...
Neuropsychological Assessment, 4th Edition edited by Muriel D. Lezak, Diane B. Howieson, and David W. Loring, 1016 pp., New York, NY, Oxford University Press, 2004, $89.50 Nearly a decade has passed since the publication of Lezak's third edition Assessment . In this time, field neuropsychology grown at tremendous pace. An explosion in use new research technologies such as fMRI greatly advanced our understanding brain-behavior relationships. addition, there been proliferation assessment...
Abstract BACKGROUND: The authors conducted a randomized clinical trial examining the effects of modafinil in reducing persistent fatigue patients after treatment for cancer and performed secondary analyses to assess effect on cognitive function. METHODS: Breast who reported score ≥2 Brief Fatigue Inventory were enrolled study. In phase 1 (P1), received 200 mg open‐label once daily 4 weeks. 2 (P2), with positive response P1 either an additional weeks or placebo. Tests memory attention...
ABSTRACT We examined the frequency of Parkinson disease with mild cognitive impairment (PD‐MCI) and its subtypes accuracy 3 scales for detecting PD‐MCI using new criteria proposed by Movement Disorders Society. Nondemented patients Parkinson's completed a clinical visit screening tests followed 1 to weeks later neuropsychological testing. Of 139 patients, 46 met Level 2 Task Force when impaired performance was based on comparisons normative scores. Forty‐two (93%) had multi‐domain MCI. At...
The overall aim of this study was to examine the relationship between subjective memory complaints and objective cognitive performance in perimenopausal women. specific aims were determine (1) if problems relate on tests, (2) other domains function, (3) noncognitive factors, such as depression, anxiety, sleep quality.Seventy-five women completed a comprehensive neuropsychological battery, which included measures attention, working memory, verbal fluency, visuospatial skill, fine motor...
To determine whether concussed students experience greater academic dysfunction than who sustain other injuries.We conducted a prospective cohort study from September 2013 through January 2015 involving high school and college visited 3 emergency departments in the Rochester, New York, area. Using telephone surveys, we compared self-reported between 70 with concussions comparison group of 108 extremity injuries at 1 week month after injury.At injury, scores were approximately 16 points...
We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer's disease (LOAD). A ten panel, predicted phenoconversion and provided 90% sensitivity 85% specificity differentiating an at-risk group from those that would remain cognitively intact. Despite these encouraging results, low positive predictive values limit the clinical usefulness of this panel as a screening tool subjects aged 70-80 years or younger. In report we re-examine our metabolomic data, analyzing...
Objectives To examine the cognitive and neural effects of vision‐based speed‐of‐processing ( VSOP ) training in older adults with amnestic mild impairment aMCI contrast those an active control (mental leisure activities MLA )). Design Randomized single‐blind controlled pilot trial. Setting Academic medical center. Participants Individuals (N = 21). Intervention Six‐week computerized training. Measurements Multiple processing measures, instrumental daily living IADL s), two resting state...
Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain aggregates in Alzheimer disease.
Abstract The cognitive deterioration of politicians is a critical emerging issue. As professions including law and medicine develop implement assessments, their insights may inform the proper strategy within politics. aging, lifetime-appointed judiciary raises legal administrative questions such while testing older physicians experiencing decline provides real-life examples implementation. In politics, assessment must contend with field’s unique challenges, also taking context-dependent...
Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes brain structure. It unknown if thickness and volumetric can identify AD stages they are similar to other genetic forms of AD. Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, 27 symptomatic). Cortical subcortical volumes compared between groups evaluated as a staging metric using receiver operating characteristic analyses. Thickness patterns those previously reported...
<b><i>Background:</i></b> AD causes visuospatial disorientation that is associated with posterior cortical atrophy and impaired visual motion processing. <b><i>Objective:</i></b> The authors characterized memory capacity processing in young normal (YN) older (ON) adult subjects patients mild cognitive impairment (MCI) to see if deficits these realms occur as isolated impairments. <b><i>Methods:</i></b> Each participant underwent neuropsychological testing gave push-button responses indicate...
Behavioral markers measured through neuropsychological testing in mild cognitive impairment (MCI) were analyzed and combined multivariate ways to predict conversion Alzheimer's disease (AD) a longitudinal study of 43 MCI patients. The test measures taken at baseline evaluation first reduced underlying components (principal component analysis, PCA), then the scores used discriminant analysis classify individuals as likely convert or not. When empirically weighted combined, episodic memory,...
Abstract Introduction The longitudinal trajectories of functional brain dynamics and the impact genetic risk factors in individuals at for Alzheimer's disease are poorly understood. Methods In a large‐scale monocentric cohort 224 amyloid stratified disease, default mode network (DMN) resting state connectivity (FC) was investigated between two serial time points across 2 years. Results Widespread DMN FC changes were shown frontal posterior areas, as well right hippocampus. There no...
Recent reports implicate gut microbiome dysbiosis in the onset and progression of Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit microbial perspective. Here, we evaluate longitudinal microbiomes metabolomes from a popular transgenic mouse for familial AD (5xfAD). Cecal fecal samples 5xfAD wild-type B6J (WT) mice 4 to 18 months age were subjected shotgun Illumina sequencing. Metabolomics was performed on plasma feces subset same animals. Significant...