Florence Lai
A5067830866- Down syndrome and intellectual disability research
- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Alzheimer's disease research and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Advanced MRI Techniques and Applications
- Respiratory viral infections research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Blood transfusion and management
- Genetics and Neurodevelopmental Disorders
- Coronary Interventions and Diagnostics
- Traumatic Brain Injury Research
- Cardiac Structural Anomalies and Repair
- Health, Environment, Cognitive Aging
National Institute for Health Research
2016-2025
University of Leicester
2016-2025
Harvard University
1982-2025
Massachusetts General Hospital
1999-2025
Glenfield Hospital
2016-2025
NIHR Leicester Cardiovascular Biomedical Research Unit
2016-2024
Mass General Brigham
2024
Syngenta (United Kingdom)
2018-2024
Harvard University Press
2024
NIHR Leicester Biomedical Research Centre
2017-2022
Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes not been evaluated comprehensively, because available studies have involved limited scope sample sizes. This study sought construct score for estimate its as screening tool primary prevention. Using meta-analytic approach combine large-scale, genome-wide, targeted genetic association data, we developed new (metaGRS) consisting 1.7...
Previous workers have attempted to predict the cumulative number of cases Coronavirus Disease 2019 (COVID-19) in China.1Fu X. Ying Q. Zeng T. Long Wang Y. Simulating and forecasting confirmed SARS-CoV-2 China by Boltzmann function-based regression analyses.J Infect. 2020; (pii: S0163-4453(20)30098-0)https://doi.org/10.1016/j.jinf.2020.02.019Abstract Full Text PDF PubMed Scopus (24) Google Scholar However, since then, epidemic has rapidly evolved into a pandemic affecting multiple countries...
Nonadherence to antihypertensive treatment is a critical contributor suboptimal blood pressure control. There are limited and heterogeneous data on the risk factors for nonadherence because few studies used objective-direct diagnostic methods. We high-performance liquid chromatography-tandem mass spectrometry of urine serum detect explored its association with main demographic- therapy-related in 1348 patients hypertension from 2 European countries. The rates were 41.6% 31.5% UK Czech...
We hypothesized that screening for nonadherence to antihypertensive treatment using liquid chromatography-tandem mass spectrometry-based biochemical analysis of urine/serum has therapeutic applications in nonadherent hypertensive patients. A retrospective patients attending specialist tertiary care centers was conducted 2 European countries (United Kingdom and Czech Republic). Nonadherence diagnosed urine Kingdom) or serum (Czech These results were subsequently discussed with each patient,...
Abstract The foremost impediment to progress in the understanding and treatment of dementia adults with intellectual disability is lack standardized criteria diagnostic procedures. Standardized for diagnosis individuals are proposed, their application discussed. In addition, procedures determining v/hether or not
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology cognitive abilities with advancing age, indicative individual variation resilience pathology. Here, we generated comprehensive neuropathological, molecular,...
Adult height is associated with risk of several diseases, but the breadth such associations and whether these are primary or due to confounding unclear. We examined association adult 50 diseases spanning multiple body systems using both epidemiological genetic approaches, latter identify un-confounded possible underlying mechanisms. for (using logistic regression adjusted potential confounders) genetically determined a two-sample Mendelian randomisation approach height-associated variants as...
Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain aggregates in Alzheimer disease.
While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due weak category justifications based on structural similarity only. Metabolomics provides a route robust categories via evidence of shared molecular effects across source and target substances. To gain international acceptance, this approach must demonstrate high reliability, best-practice guidance required. The MetAbolomics ring Trial for CHemical groupING (MATCHING), comprising...
Prior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti-amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored adults with late-onset Alzheimer's disease. This overlooks Down syndrome (DS), who often experience dementia at a younger age and different diagnostic assessment outcomes. exclusion may deny DS access to potential disease-modifying treatments. To address this issue, an...
Abstract Background We assessed the prevalence and pregnancy outcomes of pre‐existing diabetes mellitus (pre‐ DM ) gestational ( GDM in Alberta, C anada, 2005–11. Methods 327 198 singleton 5552 twin pregnancies resulting live births or stillbirths were included. The odds ratios adverse evaluated comparing pre‐ with no diabetes, controlling for maternal characteristics. Results Diabetes complicated 6.3% pregnancies, 88% being . In associated increased risks pre‐eclampsia (adjusted ratio [ aOR...
To investigate brain β-amyloid binding in subjects with Down syndrome (DS) using [(18)F]florbetaben PET imaging.Thirty-nine DS (46.3 ± 4.7 years) were assessed imaging. Three blinded independent readers the scans to provide a visual analysis. The primary quantitative imaging outcome was standardized uptake value ratio (SUVR) obtained for 6 regions. Cognitive status evaluated Dementia Screening Questionnaire Individuals Intellectual Disabilities (DSQIID).[(18)F]Florbetaben correlated age (p <...
Neonatal Vitamin K prophylaxis is an effective intervention for reducing vitamin deficiency bleeding. A recently published report of parental refusal prompted investigation the prevalence and characteristics this group, exploration whether these same parents were likely to subsequently refuse immunization their children.We conducted a retrospective population-based cohort study all infants born in Alberta between 2006 2012 by using linkage administrative health data. Risk factors determined...
Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology by their 5th decade. Compared the general population, traditional vascular risks in adults DS are rare, allowing examination of cerebrovascular this population and insight into its role AD without confound risk factors. We examined vivo magnetic resonance imaging (MRI)-based biomarkers DS, determined cross-sectional relationship age, beta-amyloid pathology, mild cognitive impairment or clinical diagnostic status.
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins decade or more prior onset clinical dementia in people DS. It is not clear if plasma biomarkers are correlated early cognitive and functional impairments DS, these could be used track the stages DS inform inclusion criteria for treatment trials. METHODS This large cross‐sectional cohort study investigated associations between amyloid beta (Aβ)42/40, total tau,...
<b><i>Background:</i></b> Alzheimer disease (AD) neuropathology is present in Down syndrome (DS) after age 35, but dementia onset varies from ages 40 to 70 years. Because of small sample sizes and nonuniform determination dementia, previous studies produced differing results on the influence <i>APOE</i> subtypes AD DS. <b><i>Objective:</i></b> To determine genotype gender development adults with DS ascertain similarities general population. <b><i>Methods:</i></b> A total 100 (ages 35 79...
Triplication of chromosome 21 in Down syndrome (DS) results overexpression the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein appears intraneuronal neurofibrillary tangles (NFTs). We have previously shown significantly more DYRK1A-positive NFTs DS brains than sporadic Alzheimer disease (AD) brains. This study demonstrates a dosage-proportional increase level cytoplasm cell nucleus, enhanced...