A5019412968- Metabolism and Genetic Disorders
- Hemoglobinopathies and Related Disorders
- Mitochondrial Function and Pathology
- Iron Metabolism and Disorders
- Neural and Behavioral Psychology Studies
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neurobiology of Language and Bilingualism
- Selenium in Biological Systems
- Cerebral Palsy and Movement Disorders
- Hemispheric Asymmetry in Neuroscience
- Dementia and Cognitive Impairment Research
- Spatial Neglect and Hemispheric Dysfunction
- Folate and B Vitamins Research
- Functional Brain Connectivity Studies
- Prenatal Screening and Diagnostics
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
Washington University in St. Louis
2013-2024
University of Washington
2009-2015
St. Louis Children's Hospital
2004-2007
Mallinckrodt (United States)
2002-2003
University of South Carolina
2002
University of Colorado Boulder
2000
University of California, San Diego
1976-1997
John Brown University
1996
Southmead Hospital
1980-1986
Duke University
1984
Abstract The present study examined neuropsychological (NP) functioning and associated medical, neurological, brain magnetic resonance imaging (MRI), psychiatric findings in 389 nondemented males infected with Human Immunodeficiency Virus-Type 1 (HIV-1), 111 uninfected controls. Using a comprehensive NP test battery, we found increased rates of impairment at each successive stage HIV infection. HIV-related was generally mild, especially the medically asymptomatic infection, most often...
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and associated recurrence of an infarct (stroke or silent infarct). We tested hypothesis that incidence would be lower among who underwent regular blood-transfusion therapy than those received standard care.In this randomized, single-blind clinical trial, we randomly assigned to receive blood transfusions (transfusion group) care (observation group). Participants were between 5 15 years age, no...
<b><i>Objective:</i></b> To determine neural correlates of recovery from aphasia after left frontal injury. <b><i>Methods:</i></b> The authors studied the verbal performance patients with infarcts centered in inferior gyrus (IFG), using a battery attention-demanding lexical tasks that normally activate IFG and simpler reading task does not recruit IFG. used positron emission tomography (PET) functional MRI (fMRI) to record activity same group during word-stem completion, one tasks. identify...
Abstract A range of neuropsychological deficits have been identified in individuals with obstructive sleep apnea syndrome (OSAS) and related to disruptions function the frontal cortex brain. We hypothesized that impairments use strategic, frontally-mediated processes facilitate learning memory would be associated long-term episodic verbal material (i.e., word lists). evaluated 28 adults OSAS 24 controls (ranging from 60 years age) using California Verbal Learning Test. General executive...
Abstract Analysis of cross-sectional data from the normative sample Wechsler Memory Scale - Third Edition (WMS-III) revealed different patterns age-related differences in memory span measures depending on type item, processing demands, and age older adult group. Regression that slope for Spatial Span raw scores was significantly more negative than Digit scores. There no significant difference, however, either between slopes forward backward or Span. Letter-Number Sequencing showed a...
Background: Silent cerebral infarct (SCI) is the most common cause of serious neurological disease in sickle cell anemia (SCA), affecting approximately 22% children. The goal this trial to determine whether blood transfusion therapy will reduce further morbidity children with SCI, and if so, magnitude benefit. Procedure: Cerebral Infarct Transfusion (SIT) Trial includes 29 clinical sites 3 subsites, a Clinical Coordinating Center, Statistical Data test following hypothesis: prophylactic SCI...
Children with sickle cell anemia have a higher-than-expected prevalence of poor educational attainment. We test two key hypotheses about attainment among students anemia, as measured by grade retention and use special education services: (1) lower household per capita income is associated attainment; (2) the presence silent cerebral infarct conducted multicenter, cross-sectional study cases from 22 U.S. sites included in Silent Infarct Transfusion Trial. During screening, parents completed...
Approximately 23 700 US children undergo invasive mechanical ventilation for acute respiratory failure annually, with unknown long-term effects on neurocognitive function.To evaluate outcomes of who survive pediatric intensive care unit (PICU) hospitalization compared their biological siblings.Prospective sibling-matched cohort study conducted at 31 PICUs and associated neuropsychology testing centers. Patients were 8 years or younger a Pediatric Cerebral Performance Category score 1...
Abstract Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen conjunction with Alzheimer’s disease (ADNC). LATE-NC typically begins the amygdala spreads to hippocampus neocortex. Whether it contributes hippocampal atrophy Down syndrome (DS) remains unexplored. We analyzed volumes neuropathological burden 12 DS cases 54 non-DS AD related neurodegenerative pathologies (ADRNP) using 7 Tesla (7T) postmortem ex vivo MRI....
Abstract Findings from previous research suggest that inhibitory control improves during early childhood and declines late adulthood. Very few researchers, however, have examined life-span changes in this ability single studies. Within context, we investigated 1 type of control-the to inhibit a prepotent response generate an incompatible response-in individuals ranging 6 82 years age. Examination raw reaction time data revealed significantly larger effect for children older adults than young...
Age-related declines in executive abilities have been widely reported and are thought to result from neuropathological changes the prefrontal cortex. Some investigators suggested that age-related cognition may be of slowed information processing speed rather than specific cognitive abilities. We examined relationships among age, abilities, psychomotor 40 older adults 46 young adults. Both verbal nonverbal tasks were administered measured 2 aspects ability: set formation shifting. Executive...