A5008552659- Down syndrome and intellectual disability research
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Attention Deficit Hyperactivity Disorder
- Frailty in Older Adults
- Child Nutrition and Feeding Issues
- Chronic Disease Management Strategies
- Family and Disability Support Research
- Behavioral and Psychological Studies
- Alzheimer's disease research and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Child Development and Digital Technology
- Medical Imaging Techniques and Applications
- Child Therapy and Development
- Pharmaceutical studies and practices
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Diabetes Management and Research
- Obstructive Sleep Apnea Research
- Health Systems, Economic Evaluations, Quality of Life
- Assistive Technology in Communication and Mobility
- Parkinson's Disease Mechanisms and Treatments
- Older Adults Driving Studies
University of Pittsburgh
2016-2025
University of Pittsburgh Medical Center
2012-2024
Children's Hospital of Pittsburgh
1987-2019
Counseling Center
2019
Pittsburg State University
2006-2018
University of Wisconsin–Madison
2017
Merck & Co., Inc., Rahway, NJ, USA (United States)
1995-2012
Western State Hospital
2012
Institute for Neurodegenerative Disorders
2012
University of Pennsylvania
2012
Disruptive behavior is common in children with autism spectrum disorder. Behavioral interventions are used to treat disruptive but have not been evaluated large-scale randomized trials.To evaluate the efficacy of parent training for disorder and behavior.This 24-week trial compared (n = 89) education 91) at 6 centers (Emory University, Indiana Ohio State University Pittsburgh, Rochester, Yale University). We screened 267 children; 180 (aged 3-7 years) behaviors were randomly assigned (86%...
The impact of abnormal feeding behaviors reported for children with autism spectrum disorders (ASDs) on their nutritional status is unknown. We compared nutrient intake from food consumed by and without ASD examined deficiency excess.Prospective 3-day records BMI (2-11 years) participating in the Autism Treatment Network (Arkansas, Cincinnati, Colorado, Pittsburgh, Rochester) were both National Health Nutrition Examination Survey data a matched subset based age, gender, family income,...
This study sought to identify factors that may be associated with delays in autism spectrum disorder (ASD) diagnosis, including birth cohort, sociodemographic characteristics, and clinical features.Participants included 1716 children adolescents ASD enrolled the Autism Speaks Treatment Network (AS-ATN) between years 2008 2011. Data were collected at enrollment using AS-ATN parent- clinician-report forms standardized measures of I.Q., symptoms, adaptive function, psychiatric symptoms.Age...
Down syndrome (DS) is one of the most common causes intellectual disability. Although DS accounts for only 15% all individuals with disabilities, adults account approximately 60% disabilities and Alzheimer's disease. This thought to be because overproduction β-amyloid (Aβ) protein due trisomy Aβ precursor gene on chromosome 21. Pittsburgh compound B (PiB) a noninvasive in vivo positron emission tomography tracer used image amyloid deposition living humans. Studies using PiB have shown an...
<h3>Importance</h3> Atypical antipsychotic medications are indicated for the treatment of irritability and agitation symptoms in children with autism spectrum disorder (ASD). Unfortunately, these associated weight gain metabolic complications that especially troubling long-term use. <h3>Objective</h3> To evaluate efficacy metformin atypical adolescents ASD (defined protocol as<i>DSM-IV</i>diagnosis autistic disorder, Asperger or pervasive developmental not otherwise specified), aged 6 to 17...
We explored patterns of concomitant psychiatric disorders in a large sample treatment-seeking children and adolescents with autism spectrum disorder (ASD). Participants were 658 ASD (age 3–17 years; mean = 7.2 years) one six federally-funded multisite randomized clinical trials (RCT) between 1999 2014. All referred for hyperactivity or irritability. Study designs varied, but all used the Child Adolescent Symptom Inventory Early Childhood to assess Attention Deficit Hyperactivity Disorder...
Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain aggregates in Alzheimer disease.
Abstract INTRODUCTION Almost all individuals with Down syndrome (DS) will develop neuropathological features of Alzheimer's disease (AD). Understanding AD biomarker trajectories is necessary for DS‐specific clinical interventions and interpretation drug‐related changes in the trajectory. METHODS A total 177 adults DS from Biomarker Consortium‐Down Syndrome (ABC‐DS) underwent positron emission tomography (PET) MR imaging. Amyloid‐beta (Aβ) were modeled to provide individual‐level estimates...
Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes brain structure. It unknown if thickness and volumetric can identify AD stages they are similar to other genetic forms of AD. Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, 27 symptomatic). Cortical subcortical volumes compared between groups evaluated as a staging metric using receiver operating characteristic analyses. Thickness patterns those previously reported...
Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 3%–5% of typical school-age children. However, considerably higher rates ADHD (15%–25%) are observed in children with intellectual disability and autism. Studies psychostimulants the latter two populations have found poorer response compared to typically developing In addition, evidence suggests that developmental disabilities experience adverse events. Guanfacine, an α2-adrenergic receptor agonist, has shown some promise as...
Nearly all adults with Down syndrome show neuropathology of Alzheimer's disease, including amyloid-β deposition, by their fifth decade life. In the current study, we examined association between brain assessed via in vivo assessments neocortical Pittsburgh compound B, and scores on an extensive neuropsychological battery measures cognitive functioning 63 (31 male, 32 female) aged 30–53 years who did not exhibit symptoms dementia. Twenty-two were identified as having elevated B retention...