A5004471376- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Obsessive-Compulsive Spectrum Disorders
- Behavioral and Psychological Studies
- Child and Adolescent Psychosocial and Emotional Development
- Bullying, Victimization, and Aggression
- Sexuality, Behavior, and Technology
- Virology and Viral Diseases
- Eating Disorders and Behaviors
- Cognitive Abilities and Testing
- Plant Virus Research Studies
- Attention Deficit Hyperactivity Disorder
- Early Childhood Education and Development
South London and Maudsley NHS Foundation Trust
2019-2023
Maudsley Hospital
2022
King's College London
2009-2015
Medical Research Council
2013
King's College - North Carolina
2009-2013
Yale University
2012-2013
Child Development Center
2011
Birkbeck, University of London
2009
Most evidence to date highlights the importance of genetic influences on liability autism and related traits. However, most these findings are derived from clinically ascertained samples, possibly missing individuals with subtler manifestations, obtained estimates may not be representative population.To establish relative contributions environmental factors in spectrum disorder (ASD) a broader phenotype large population-based twin sample ascertain genetic/environmental relationship between...
Disruptive behavior is common in children with autism spectrum disorder. Behavioral interventions are used to treat disruptive but have not been evaluated large-scale randomized trials.To evaluate the efficacy of parent training for disorder and behavior.This 24-week trial compared (n = 89) education 91) at 6 centers (Emory University, Indiana Ohio State University Pittsburgh, Rochester, Yale University). We screened 267 children; 180 (aged 3-7 years) behaviors were randomly assigned (86%...
<h3>Context</h3>Genetic factors play an important role in the etiology of both autism spectrum disorders and autistic traits. However, little is known about etiologic consistency traits across levels severity.<h3>Objective</h3>To compare typical variation with extreme scoring groups (including top 1%) that mimicked prevalence diagnosed largest twin study to date.<h3>Design</h3>Twin using phenotypic analysis genetic model-fitting total sample (top 5%, 2.5%, 1%).<h3>Setting</h3>A nationally...
The current study examined the self-reported prevalence and nature of cyberbullying victimization among second, third, fourth grade students (N=372) explored associated features home school life. Of children in sample, 27 percent had been victims cyberbullying, 18 aggressors, 15 both cyberbullies victims. Boys were significantly more likely to carry out than girls. Cyberbullying exposure (as a bully victim) was with low levels satisfaction (bullies odds ratio [OR]: 2.45; OR: 2.10; p<0.05)...
Background Although many children with autism spectrum disorders ( ASD s) experience difficulties anxiety, the manifestation of these remains unresolved. The current study assessed anxiety in a large population‐based twin sample, aged 10–15 years. Phenotypic analyses were used to explore symptoms s, their unaffected co‐twins and control sample. Methods Participants included 146 families from Twins Early Development Study TEDS ) where one or both had suspected . Eighty also included. Revised...
Background The behavioural symptoms of autism spectrum disorder ( ASD ) are thought to reflect underlying cognitive deficits/differences. findings in the literature somewhat mixed regarding features . This study attempted address this issue by investigating a range deficits and prevalence multiple atypicalities large population‐based sample comprising children with , their unaffected co‐twins, typically developing comparison children. Methods Participants included families from Twins Early...
Objective Children with autism spectrum disorders often experience severe anxiety and depression, yet the explanation for this association remains unclear. The authors examined longitudinal relationship between autistic-like internalizing traits across middle to late childhood in a population-representative twin sample. Method Participants were approximately 6,000 pairs born England Wales from 1994 1996. Parental reports of analyzed at ages 7 8 (timepoint 1) again age 12 2). direction...
ObjectiveDisorders on the autism spectrum, as well autistic traits in general population, have been found to be both highly stable across age and heritable at individual ages. However, little is known about overlap genetic environmental influences contribution of such trait stability itself. The present study investigated these questions a population sample twins.MethodMore than 6,000 twin pairs were rated an established scale by their parents 8, 9, 12 years teachers 9 age. Data analyzed...
Anxiety-related behaviors (ARBs) are commonly observed during typical development, yet few studies have investigated their etiology in middle childhood. This study aimed to examine both the phenotypic and genetic differentiation of ARB subtypes within general population at age 7 9. It constituted a follow-up an earlier ARBs preschool children.We structure large population-based twin sample, comprising 7,834 pairs 3,644 Quantitative modeling techniques were then used determine relative...
Background Increasing numbers of people are being referred for the assessment autism spectrum disorder ( ASD ). The NICE UK ) and American Academy Pediatrics recommend gathering a developmental history using tool that operationalises ICD / DSM criteria. However, best‐established diagnostic interview instruments time consuming, costly rarely used outside national specialist centres. What is needed brief, cost‐effective measure validated in community settings. We tested Development Well‐Being...
The majority of young autistic children display impairing emotional and behavioural difficulties that contribute to family stress. There is some evidence parenting interventions are effective for reducing in children, with less assessing change difficulties. Previous trials have tended use unblinded parent-report measures as primary outcomes many do not employ an active control, limiting the conclusions can be drawn.
ObjectiveMost young autistic children display emotional and behavioral problems (EBPs). There is evidence that parenting interventions (BPIs) reduce these. The COVID-19 pandemic associated lockdowns can be seen as a natural experiment to test the longer-term effect of BPIs under conditions increased uncertainty.MethodOpportunistic follow-up (n = 49) pilot randomized controlled trial (RCT) cohort 62 aged 6-11 years; originally 12-week group BPI [Predictive Parenting; n 31] or an attention...
Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate sensitivity Children's Yale-Brown Obsessive Compulsive Scale modified for disorder detect change treatment. Study 1 included 52 subjects assigned placebo and 49 under double-blind conditions. In 2, received only 75 plus parent training. The...