A5077729374- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Bone and Joint Diseases
- Erythrocyte Function and Pathophysiology
- Folate and B Vitamins Research
- Blood disorders and treatments
- Erythropoietin and Anemia Treatment
- Pharmacological Effects and Toxicity Studies
- MRI in cancer diagnosis
- Cell Adhesion Molecules Research
- Trace Elements in Health
- Prenatal Screening and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Acute Ischemic Stroke Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Algebraic Geometry and Number Theory
- Heme Oxygenase-1 and Carbon Monoxide
- Cellular Mechanics and Interactions
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
University of Southern California
2016-2025
Children's Hospital of Los Angeles
2016-2025
Children's Center
2015-2024
Keck Hospital of USC
2011-2023
Southern California University for Professional Studies
1992-2023
Florey Institute of Neuroscience and Mental Health
2016-2020
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2016-2020
Although sickle cell disease (SCD) is marked by high utilization of medical resources, the full cost care for patients with SCD, including not directly related to unknown. The purpose this study was estimate total a population children and adults SCD. We used data from individuals diagnosed SCD enrolled in Florida Medicaid program during 2001-2005 total, SCD-related, non-SCD-related per patient-month based on patient age at time health use. Across 4,294 samples, costs generally rose age,...
Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of units transfused) in such patients.
Summary Deferasirox is a once‐daily, oral iron chelator developed for treating transfusional overload. Preclinical studies indicated that the kidney was potential target organ of toxicity. As patients with sickle cell disease often have abnormal baseline renal function, primary objective this randomised, open‐label, phase II trial to evaluate safety and tolerability deferasirox in comparison deferoxamine population. Assessment efficacy, as measured by change liver concentration (LIC) using...
Background— Transfusional therapy for thalassemia major and sickle cell disease can lead to iron deposition damage the heart, liver, endocrine organs. Iron causes MRI parameters T1, T2, T2* shorten in these organs, which creates a potential mechanism quantification. However, because of danger variability cardiac biopsy, tissue validation estimates by has not been performed. In this study, we demonstrate that produces similar changes heart liver using gerbil iron-overload model. Methods...
EIGHT years ago Strauss et al. reported unique structural abnormalities in the granulocytes of a boy who had recurrent bacterial infections since birth.1 The nuclei were bilobed, and ultrastructural studies specific-granule membranes appeared as elongated vesicular sacs. After ingestion Staphylococcus aureus by cells, impaired phagolysosome fusion was noted; this accompanied mild impairment bactericidal activities. Since initial study patient has continued to have deep-seated skin abscesses,...
Pancreatic iron overload and diabetes mellitus (DM) are common in thalassemia major patients. However, the relationship between stores glucose disturbances is not well defined. We used a frequently sampled oral tolerance test (OGTT), coupled with mathematical modeling, magnetic resonance imaging (MRI) to examine impact of pancreatic, cardiac, hepatic on regulation 59 patients major. According OGTT results, 11 had DM, 12 impaired (IGT), 8 isolated fasting (IFG), 28 normal (NGT). Patients DM...
Hypogonadism is the most common morbidity in patients with transfusion-dependent anemias such as thalassemia major. We used magnetic resonance imaging (MRI) to measure pituitary R2 (iron) and volume determine at what age these develop iron overload loss. recruited 56 (47 major, five chronically transfused intermedia four Blackfan-Diamond syndrome) have MRIs volume. was defined clinically based on timing of secondary sexual characteristics or need for sex hormone replacement therapy. Patients...
Prevention and management of end-organ disease represent major challenges facing providers children adults with sickle cell (SCD). Uncertainty variability in the screening, diagnosis, cardiopulmonary renal complications SCD lead to varying outcomes for affected individuals.
Background Transfusions are the primary therapy for thalassemia but have significant cumulative risks. In 2004, C enters D isease ontrol and P revention ( CDC ) established a national blood safety monitoring program thalassemia. This report summarizes population their previous nonimmune immune transfusion complications. Study Design Methods The T halassemia B lood S afety N etwork is consortium of centers longitudinally following patients. Enrollment occurred from 2004 through 2012....
We examined whether and how an HIV prevention diffusion-based intervention spread throughout participants' online social networks changes in network ties were associated with increased testing behaviors.We randomly assigned 112 primarily racial/ethnic minority men who have sex (MSM) to receive peer-delivered (intervention) or general health (control) information over 12 weeks through closed Facebook groups. recorded public friend at baseline (September 2010) follow-up (February 2011),...
Abstract Purpose To optimize R2*(1/T2*) measurements for cardiac iron detection in sickle cell and thalassemia patients. Materials Methods We studied 31 patients with transfusion‐dependent disease 48 major; myocardial R2* was assessed a single midpapillary slice using gated gradient‐echo pulse sequence. Pixel‐wise maps were coregistered among the to determine systematic spatial fluctuations R2*. The contributions of minimum TE, echo spacing, signal‐decay model, region‐of‐interest (ROI)...