A5084028538- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Blood groups and transfusion
- Blood Pressure and Hypertension Studies
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Folate and B Vitamins Research
- Platelet Disorders and Treatments
- Cancer survivorship and care
- Family Support in Illness
- Erythrocyte Function and Pathophysiology
- Atrial Fibrillation Management and Outcomes
- Synthesis and Biological Activity
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolism and Genetic Disorders
University of Malaya
2016-2025
University Malaya Medical Centre
2010-2024
KPJ Ampang Puteri Specialist Hospital
2017
Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of units transfused) in such patients.
Aim: Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in toxicity. We aimed evaluate the impact SNPs within MTX pathway genes on MTX-induced toxicity and plasma levels at 48 h following treatment Asian adults with acute lymphoblastic leukemia or non-Hodgkin lymphoma. Patients & methods: (n = 71) were genotyped for MTHFR C677T, A1298C, SLC19A1 G80A, ABCG2 C421A ABCB1 C3435T using Sequenom MassARRAY® platform. Plasma concentrations measured by fluorescence...
Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes individuals of European ancestry, yet its utility Asian patients remains unresolved.An open-label, non-inferiority, 1:1 trial was conducted at three academic hospitals South East Asia, involving 322 ethnically diverse newly indicated for (NCT00700895). Clinical follow-up 90 days. The primary efficacy measure the number dose titrations within first 2 weeks therapy, with a mean...
Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase expectancy brought about by advances medical care. This study aimed compare QOL, treatment satisfaction, hospitalization bleeding rate patients warfarin versus direct anticoagulants (DOAC). Methods: was a cross-sectional with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) attending cardiology clinic...
INTRODUCTION: The pathogenesis of classical myeloproliferative neoplasm (MPN) driven by JAK2, CALR and MPL gene mutations affects the clinical course survival. This study aimed to determine prevalence driver in MPN patients their association with presentations outcomes. MATERIALS AND METHODS: We conducted a retrospective involving diagnosed from 2002 2019. patient's laboratory information, as well outcomes, were collected reviewed. RESULTS: 267 recruited into study. Majority these Chinese...
This study aims to describe the incidence and risk factors of invasive fungal infection (IFI) among patients with haematological malignancies (HM) in a tertiary hospital from Malaysia. was cross-sectional teaching involving HM patients, admitted for chemotherapy or haematopoietic stem cell transplantation (HSCT). Each admission either HSCT considered as separate event. Patients were followed up development IFI time each discharge death. Outcomes upon recorded. Clinical mycological data...
Acute promyelocytic leukemia with concurrent myeloid sarcoma is a rare clinical event.Herein we describe patient that presented back pain and bilateral leg weakness caused by spinal cord compression due to extramedullary deposition of leukemic cells.Acute was suspected based on immunophenotypic findings malignant cells in bone marrow aspirate.The diagnosis confirmed the presence PML-RARα fusion copies.MRI showed multiple hyperintense changes vertebral bodies, together intraspinal masses...
Poor adherence to tyrosine kinase inhibitors (TKIs) could compromise the control of chronic myeloid leukemia (CML) and contributes poorer survival. Little is known about how medication-related issues affect CML patients' TKI therapy in Malaysia. This qualitative study aimed explore these issues.Individual face-to-face, semistructured interviews were conducted at hematology outpatient clinics two medical centers Malaysia from August 2015 January 2016. patients aged ≥18 years who prescribed a...
Malaria is caused by parasitic protozoans of the genus Plasmodium and one most prevalent infectious diseases in tropical subtropical regions. For this reason, effective practical diagnostic methods are urgently needed to control spread malaria. The aim current study was identify a panel new malarial markers, which could be used diagnose patients infected with various species, including P. knowlesi, vivax falciparum. Sera from malaria-infected were pooled compared sera obtained healthy...
Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape chronic myeloid leukemia (CML). Therefore, availability a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance research this area. We performed an international study including 782 assess validity EORTC QLQ-CML 24 and generate reference values interpretation results future studies. Internal...
Quality of life (QOL) family caregivers cancer patients is usually affected due to increase in caregiver burden. Their QOL has not garnered much attention by many including the health professionals and community. This study aims explore a multi-ethnic country Asia investigate its associate factors.This cross-sectional where who were diagnosed cancers within 12 months recruited. measured using The Caregiver Life Index-Cancer (CQOLC). Psychological distress was Hospital anxiety depressive...
We present a case of beta-propeller protein-associated neurodegeneration, form neurodegeneration with brain iron accumulation.The patient harbored novel mutation in the WDR45 gene.A detailed video and description her clinical condition are provided.Her movement disorder phenomenology was characterized primarily by limb stereotypies gait dyspraxia.The patient's disability advanced time iron-chelating therapy deferiprone initiated, no response terms cognitive function, behavior, speech, or...
Abstract Background The use of warfarin in patients with non-valvular atrial fibrillation (NVAF) can be challenging. In this study, we evaluate the time therapeutic range (TTR), health-related quality life (HRQoL) and treatment satisfaction on long-term for NVAF. HRQoL were compared based TTR. Methods A cross-sectional study was conducted among NVAF who attended anticoagulant clinic a tertiary cardiology referral center Sarawak from 1st June 2018 to 31st May 2019. Patients’ TTR calculated by...
We evaluated the association of two IL10 single nucleotide polymorphisms (SNPs) (rs1800896 and rs1800871) with non-Hodgkin lymphoma (NHL) risk in three major races Malaysian population (Malay, Chinese Indian; 317 cases 330 controls). Our initial screening demonstrated that rs1800871 but not rs1800896 was significantly associated increased NHL Malays (pMalay-Rec = 0.007) only (pChinese-Rec 0.039). Subsequent combined analysis Malay revealed significant all (ALL) subtypes (pMeta-ALL-NHL-Rec...