A5086368765- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Complement system in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Platelet Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Erythropoietin and Anemia Treatment
- Pregnancy and preeclampsia studies
- Multiple Myeloma Research and Treatments
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Gastrointestinal disorders and treatments
- Hepatitis B Virus Studies
- Trace Elements in Health
- Neonatal Health and Biochemistry
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Hemophilia Treatment and Research
- Protein Degradation and Inhibitors
University Hospital of Larissa
2025
Hippocration General Hospital
2015-2025
Aristotle University of Thessaloniki
2015-2025
Ippokrateio General Hospital of Thessaloniki
2014-2024
Senologic Hellenic Society
2014
Hellenic Society for the Study of Bone Metabolism
2013
UK Thalassaemia Society
2008
Papageorgiou General Hospital
2003
Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of units transfused) in such patients.
Sickle Cell Disease (SCD) is a monogenic disease caused by nucleotide mutation in the β-globin gene. Current gene therapy studies are mainly focused on lentivirus vector-mediated addition or CRISPR/Cas9-mediated fetal globin reactivation, leaving root cause unfixed. We developed vectorized prime editing system that can directly repair SCD hematopoietic stem cells (HSCs) vivo mouse model (CD46/Townes mice). Our approach involved single intravenous injection of non-integrating,...
Gestational diabetes mellitus (GDM) is a common metabolic disorder that often develops during pregnancy, characterized by glucose intolerance and insulin resistance (IR). To ensure the well-being of both mother fetus, body undergoes multiple immunological changes result in peripheral IR and, under certain hereditary or acquired abnormalities, GDM predisposed women. The adverse short- long-term effects impact fetus. Nutrition seems to play an important role prevent improve its evolution. An...
Summary This study examined mortality rates among 2475 patients with thalassaemia and sickle cell disease (SCD) per year over 12 years in Greece, recording 335 deaths (27.92/year), an overall rate of 1.13% year. The primary aim was to identify causes death, comorbidities, treatment efficacy iron overload prevalence. Of the deaths, 239 were attributed 96 SCD. For patients, cardiac failure, hepatocellular carcinoma sepsis leading no neoplasms observed β+/β+ genotypes. In SCD, sepsis, liver...
Individuals with β-thalassemia or sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% (HbF) appear to be symptom free. Here, we used a nonintegrating HDAd5/35++ vector expressing highly efficient accurate version an adenine base editor (ABE8e) install, in vivo, -113 A>G HPFH mutation the γ-globin promoters healthy CD46/β-YAC mice carrying human β-globin locus. Our vivo hematopoietic stem (HSC) editing/selection strategy involves only s.c. i.v. injections...
Abstract Our aim was to assess liver iron content, in thalassaemic patients, by using three different MR protocols and compare their data. Ninety‐four patients (44 M 50 F, mean age 25.82 ± 8.3 yrs), were enrolled the study. In each patient, measurements of content performed, with use a single imager, equipped 1.5 Tesla magnet. Liver R2* measured on gradient‐echo sequence. Calculation MR‐HIC values based an algorithm muscle (L/M) ratios five axial sequences. Finally, determination R2 employed...
The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through development safe efficient platforms. In this study, an innovative (international patent-pending) methodology was developed, combining IVT-mRNAs with transduction domain (PTD) technology, as platform. Based PTD which enables various cargoes intracellularly, conjugation a...
Introduction Bystander hemolysis occurs when antigen-negative red blood cells (RBCs) are lysed by the complement system. Many clinical entities including passenger lymphocyte syndrome, hyperhemolysis following transfusion, and paroxysmal nocturnal hemoglobinuria complicated bystander hemolysis.
Delayed hemolytic transfusion reaction (DHTR) is a life-threatening complication in patients with sickle cell disease, characterized by difficulties diagnosis and management. Certain reports have suggested successful salvage treatment the terminal complement inhibitor, eculizumab. We here report evidence of activation inhibition one dose eculizumab an adult disease patient presenting DHTR hyperhemolysis. A 21-year old female [Hb S (HBB: c.20A>T)/β-thalassemia (β-thal)] presented at our Adult...
The assessment of health-related quality life (HRQoL) in thalassemia offers a holistic approach to the disease and facilitates better communication between physicians patients. This study aimed evaluate HRQoL transfusion-dependent (TDT) patients Greece. was multicentric, cross-sectional conducted 2017 involving 283 adult TDT All participants completed set two QoL questionnaires, generic SF-36v2 disease-specific TranQol. Demographic clinical characteristics were used predefine patient...
Background/Objectives: B-thalassemia is a genetic disorder that leads to reduced or absent β-globin chains, often resulting in endocrine abnormalities due iron overload, chronic anemia, and hypoxia. This study investigates the prevalence risk factors for glucose metabolism disturbances transfusion-dependent β-thalassemia (TDT) patients, focusing on pancreatic overload its association with other biomarkers. Methods: We studied two groups of TDT patients (2018–2022) at Hippokration General...
Background: In this prospective study, the prognostic role of ADAMTS13 activity and von Willebrand (VWF) antigen (VWF: Ag) levels in ischemic stroke outcomes was investigated. Methods: Patients diagnosed with acute were prospectively enrolled while samples for VWF: Ag level measurements collected upon their admission to our unit. The National Institutes Health Stroke Scale (NIHSS) score estimated at discharge. modified Rankin scale neurologic disability (Rankin) based on patient's history...