A5018221472- Complement system in diseases
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Blood Pressure and Hypertension Studies
- Blood groups and transfusion
- Cardiovascular Health and Disease Prevention
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Neutropenia and Cancer Infections
- Extracellular vesicles in disease
- Sodium Intake and Health
Aristotle University of Thessaloniki
2016-2025
G. Papanikolaou General Hospital
2016-2025
Papageorgiou General Hospital
2015-2025
Hippocration General Hospital
2023-2025
Inserm
2023
Centre de recherche en Epidémiologie et Santé des Populations
2023
Université Paris-Saclay
2023
Centre Hospitalier Sud Francilien
2023
Hospital Universitario Infanta Leonor
2023
Universität Hamburg
2023
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation the alternative pathway complement that treated with eculizumab, a humanized monoclonal antibody against terminal component C5. Eculizumab must be administered intravenously, moreover some patients paroxysmal on eculizumab have symptomatic extravascular hemolysis, indicating an unmet need for additional therapeutic approaches. We report activity two novel small-molecule inhibitors...
There is an unmet need of models for early prediction morbidity and mortality Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes ICU hospitalization death, b) develop artificial neural network (ANN) predicting these c) validate whether are impaired complement phenotype. prospectively recruited consecutive adult patients Caucasian origin, hospitalized due COVID-19. Through targeted next-generation sequencing, we...
The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. aim present study was to retrospectively analyse the and risk factors for mortality a large series patients who developed infection after an HSCT.This multicenter retrospective promoted by European Hematology Association - Infections Study Working Group, included 326 adult HSCT had between January 2020 March 2022.The median time from diagnosis 268 days (IQR...
Abstract Complement inhibition has shown promise in various disorders, including COVID‐19. A prediction tool complement genetic variants is vital. This study aims to identify crucial complement‐related and determine an optimal pattern for accurate disease outcome prediction. Genetic data from 204 COVID‐19 patients hospitalized between April 2020 2021 at three referral centres were analysed using artificial intelligence‐based algorithm predict (ICU vs. non‐ICU admission). recently introduced...
Abstract Background Changes in retinal vessel caliber are crucial for detecting early retinopathy, a significant cause of blindness individuals with Diabetes Mellitus type 2 (T2DM). This study aims to evaluate the changes and identify factors associated these recently diagnosed T2DM patients. Methods The included newly patients (within 6 months diagnosis) who were free antidiabetic treatment (except metformin) matched based on age blood pressure (BP). Data collected somatometric...
Background/Objectives: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis or obstetric complications and the laboratory detection of antiphospholipid antibodies. Although vascular main manifestation disease, other rarer have also been described. Avascular necrosis (AN) considered rare APS. The aim our case series to study patients with APS AN. Methods: A retrospective was performed on 80 diagnosed Results: AN observed in 3 out femoral head all cases....
Although impairment of the micro- and macrocirculation is considered inherent to sustained hypertension, there a substantial lack studies investigating whether an association exists between macrovascular damage, especially in early-stage hypertension. We studied meticulously selected population, free diabetes cardiovascular disease, 223 individuals: 137 never-treated, newly diagnosed patients with recent onset hypertension 86 normotensive individuals. Nonmydriatic retinal photography was...
Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, role complement system, neutrophils, coagulation has not been clarified. In an effort distinguish pathogenesis TA-TMA from GVHD, we evaluated markers activation, neutrophil extracellular trap (NET)...
Abstract Patients with previous CD19-directed chimeric antigen receptor (CAR) T-cell therapy have a prolonged vulnerability to viral infections. Coronavirus disease 2019 (COVID-19) has great impact and previously been shown cause high mortality in this population. Until now, real-world data on the of vaccination treatment patients COVID-19 after CAR are lacking. Therefore, multicenter, retrospective study was conducted from EPICOVIDEHA survey. Sixty-four were identified. The overall caused...