Luisa Verga
A5061887463- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Nail Diseases and Treatments
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hematopoietic Stem Cell Transplantation
- Cardiac Arrest and Resuscitation
Azienda Ospedaliera San Gerardo
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2025
Istituto Ortopedico Gaetano Pini
2025
University of Milano-Bicocca
2014-2024
Azienda Socio Sanitaria Territoriale Lariana
2020-2021
John Wiley & Sons (United States)
2020
Hudson Institute
2020
North-Western State Medical University named after I.I. Mechnikov
2019
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics HM patients developing COVID-19 and analyzed predictors mortality. The survey was supported by the Scientific Working Group Infection Hematology European Association (EHA). Eligible analysis were adult laboratory-confirmed...
Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management AML patients COVID-19 has not been established. Our multicenter study included 388 adult diagnosed between February 2020 and October 2021. vast majority were receiving or had received treatment in the preceding 3 months. was severe 41.2% critical 21.1% cases. chemotherapeutic schedule modified 174 (44.8%), delayed 68 permanently discontinued 106. After a...
The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. aim present study was to retrospectively analyse the and risk factors for mortality a large series patients who developed infection after an HSCT.This multicenter retrospective promoted by European Hematology Association - Infections Study Working Group, included 326 adult HSCT had between January 2020 March 2022.The median time from diagnosis 268 days (IQR...
BackgroundThe COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, monoclonal antibodies have been effective the general population, their benefits these patients may not be as pronounced.MethodsThe EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers data from malignancy since pandemic's...
Background. To analyze the efficacy of antifungal prophylaxis (AFP) with posaconazole and itraconazole in a real-life setting patients acute myeloid leukemia (AML) during first induction remission. Methods. From January 2010 to June 2011, all newly diagnosed AML were consecutively registered prospectively monitored at 30 Italian hematological centers. Our analysis focused on adult who received intensive chemotherapy mold-active AFP for least 5 days. determine prophylaxis, invasive fungal...
Correct definition of the level risk invasive fungal infections is first step in improving targeting preventive strategies. We investigated potential relationship between pre-hospitalization exposure to sources fungi and development adult patients with newly diagnosed acute myeloid leukemia after their course chemotherapy. From January 2010 April 2012, all consecutive 33 Italian centers were prospectively registered. Upon admission, information about possible pre-chemotherapy factors...
Objectives: To prevent invasive fungal disease (IFD) in adult patients undergoing remission-induction chemotherapy for newly diagnosed acute lymphoblastic leukaemia (ALL). Patients and methods: In a double-blind multicentre Phase 3 study, received prophylactic liposomal amphotericin B (L-AMB) at 5 mg/kg intravenously or placebo twice weekly 2:1 random allocation during treatment. The primary endpoint was the development of proven probable IFD. Secondary endpoints included those focused on...
Invasive fungal infections (IFI) of the Central Nervous System (IFI-CNS) and Paranasal Sinuses (IFI-PS) are rare, life-threatening in haematologic patients, their management remains a challenge despite availability new diagnostic techniques novel antifungal agents. In addition, analyses large cohorts patients focusing on these rare IFI still lacking. Between January 2010 December 2016, 89 consecutive cases Proven (53) or Probable (36) IFI-CNS (71/89) IFI-PS (18/89) were collected 34...
Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent (20)19 disease (COVID-19)-related death. The changing epidemiological therapeutic scenarios suggest that there has been improvement in severity survival COVID-19 during the different waves pandemic general population, but this not investigated yet MM patients. Here we analyzed a large cohort 1221 patients with confirmed SARS-CoV-2...
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven lymphoproliferative disease that usually arises in the context of reduced immunological surveillance. Based on histology, two forms are recognized, namely low-grade and high-grade LYG. Clinically, LYG universally involves lungs and, frequently, also skin, central nervous system, liver, kidneys. Here, we present case 55-year-old woman with difficult-to-diagnose symptomatic lung involvement, who concomitantly was newly...
Abstract Background Fungal infections are still a relevant challenge for clinicians involved in the cure of patients with cancer. We retrospectively reviewed charts hospitalized haematological malignancies (HMs), which documented fungaemia was diagnosed between January 2011 and December 2015 at 28 adult 6 paediatric Italian Hematology Departments. Methods During study period, we recorded 215 fungal bloodstream (BSI). Microbiological analyses that BSI due to moulds 17 (8%) yeasts 198 (92%),...
Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated targeted drugs laboratory-confirmed COVID-19 diagnosed between February 2020 January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than...
Large B-cell lymphoma (LBCL) carrying MYC rearrangement, alone or together with BCL2 and/or BCL6 translocations, have shown a poor prognosis when treated rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in the HIV population. Scanty data are available on prevalence prognostic impact of rearrangements HIV-associated LBCL. We conducted retrospective study to evaluate clinical effect rearrangement evaluated characteristics, treatment received, outcome LBCL...
Background: Greater Trochanteric Pain Syndrome (GTPS) is a frequent clinical condition characterized by acute or chronic pain in the lateral region of hip. This primarily due to gluteus minimus and medius tendinopathy. Swine-derived type I collagen has shown positive effect on tenocytes through vitro studies tendinopathies studies. pilot study aims evaluate effects swine-derived injections pain, hip function, strength GTPS patients. Methods: The group was treated with three ultrasound-guided...
Invasive fungal infections (IFIs) are considered a major problem among patients undergoing acute leukaemia (AL) induction treatment. PROphylaxis of Fungal invasive Infections in Leukaemia-Caspofungin (PROFIL-C) is multicentre study aiming to assess the comparative yield using caspofungin versus standard policy (SP) regimens and overall impact IFI routine clinical care conditions. All AL receiving prophylaxis according local SP were prospectively included by Northern Italy Leukaemia Group...
Abstract: This study was performed to evaluate the incidence, risk factors, and outcome of cytomegalovirus (CMV) infection in autologous stem cell transplantation (ASCT), with aim performing preemptive therapy patients antigenemia. Starting from 2001, 171 consecutive ASCTs were 136 patients; 102 these seropositive for CMV at onset hematological disease. In all patients, a pp65 antigenemia assay determined weekly, starting day when absolute neutrophil count went above 500/μL, until 60 after...
ObjectivesTo investigate the incidence, treatment and outcome of breakthrough invasive fungal infections (IFIs) in adult acute myeloid leukaemia (AML) patients after posaconazole prophylaxis.
Candidaemia is an important infectious complication for haematological malignancy patients. Antifungal prophylaxis reduces the incidence of candidaemia but may be associated with breakthrough candidaemia.To analyse Candida species' distribution and relative antifungal susceptibility profiles episodes in relation to use among Italian SEIFEM haematology centres.This multicentre retrospective observational study included 133 single-species patients whom testing results blood isolates were...
Summary We describe the opportunistic infections occurring in 362 patients with lymphoproliferative disorders treated ibrutinib and idelalisib clinical practice. Overall, 108 of (29·8%) developed infections, for a total 152 events. Clinically defined (CDI) were 49·3% (75/152) microbiologically (MDI) 50·7% (77/152). Among 250 ibrutinib, 28·8% (72/250) experienced one or more 104 episodes. MDI 49% (51/104). Bacterial 66·7% (34/51), viral 19·6% (10/51) invasive fungal diseases (IFD) 13·7%...
Patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPN) typically incur high rates of infections and both drugs comorbidities may modulate infection risk.The present study aims to assess the effect immunosuppressive agents on clinical outcomes MPN patients affected by coronavirus disease 2019 (COVID-19).This is an observational study.We specifically searched analyzed collected EPICOVIDEHA online registry, which includes individuals hematological malignancies diagnosed...