A5019221316- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Biochemical and Molecular Research
- Lymphoma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- Cytomegalovirus and herpesvirus research
- Bone and Joint Diseases
- Adrenal and Paraganglionic Tumors
Düsseldorf University Hospital
2014-2024
Heinrich Heine University Düsseldorf
2015-2024
Städtisches Klinikum Solingen
2022-2023
Istanbul Bilim University
2012
Justus-Liebig-Universität Gießen
2012
Bezmiâlem Vakıf Üniversitesi
2012
To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) to identify predictors response survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, 28), or myeloproliferative syndrome (n 2). All received a median number 4 courses Aza (range, 14) DLI were administered 105 (68%; DLI, 2; range, 1...
Despite recent advances in adapting the intensity of treatment for older patients with ALL, current protocols are associated high rates early deaths, treatment-related toxicity, and dismal prognosis. We evaluated inotuzumab ozogamicin dexamethasone (Dex) as induction therapy ALL within German Multicenter Study Group Adult (GMALL).
Objectives: To prevent invasive fungal disease (IFD) in adult patients undergoing remission-induction chemotherapy for newly diagnosed acute lymphoblastic leukaemia (ALL). Patients and methods: In a double-blind multicentre Phase 3 study, received prophylactic liposomal amphotericin B (L-AMB) at 5 mg/kg intravenously or placebo twice weekly 2:1 random allocation during treatment. The primary endpoint was the development of proven probable IFD. Secondary endpoints included those focused on...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for patients with advanced myelodysplastic syndrome (MDS) and secondary acute myelogenous leukemia (sAML), but in absence of prospective trials impact pretransplant cytoreduction controversially discussed. We retrospectively analyzed outcome 165 MDS excess blasts (n = 126, 76%) sAML 39, 24%) according to a strategy. Sixty-seven (41%) were directly transplanted (upfront group), whereas 98 (59%) had...
Abstract In contrast to B-cell precursor acute lymphoblastic leukemia (ALL), molecular subgroups are less well defined in T-lineage ALL. Comprehensive studies on T-ALL have been predominantly performed pediatric ALL patients. Currently, characteristics rarely considered for risk stratification. Herein, we present a homogenously treated cohort of 230 adult patients characterized transcriptome, and partly DNA methylation gene mutation level correlation with clinical outcome. We identified nine...
For patients with relapsed or refractory multiple myeloma (MM) treated a prior high-dose therapy (HDT) followed by autologous peripheral blood stem cell transplantation (PBSCT), the reapplication of HDT is widely used salvage strategy. In this retrospective study, we report on 55 who were at our institution. The conditioning regimen consisted melphalan 200 mg/m2 (27%), 140 and busulfan 12 mg/kg body weight (40%), bortezomib 1.3 (33%). Treatment-related mortality was 5% response rates as...
Abstract Objective Patients with acute myeloid leukemia ( AML ) carrying FLT 3‐ ITD mutations +) who relapse after allogeneic transplantation (allo‐ SCT have a very dismal prognosis the currently available treatment options. Methods We treated eight patients + had relapsed in median 91 d (range, 28–249) following allo‐ combination of multikinase inhibitor sorafenib and DNA methyltransferase azacitidine (Aza). Results received five cycles Aza 2–9) daily dosage 750 mg (range 400–800) for 129...
Overexpression of the Wilms' tumor 1 (WT1) gene is informative in many patients with acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS) measurable peripheral blood (PB). Despite these advantages, WT1 has not broadly been established as a marker for minimal residual disease (MRD) monitoring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) due to limited patient numbers, differing sample sources, nonstandardized in-house methods. To estimate value an MRD...
Patients suffering from high-risk myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) secondary to MDS (sAML) are characterized by poor response conventional cytotoxic chemotherapy. The purpose of our prospective single-center study was examine the safety and efficacy an allogeneic hematopoietic stem cell transplantation (HSCT) following a sequential conditioning regimen as first-line therapy for previously untreated patients with sAML. Between November 2003 June 2010, 30 (20...
Recurrence of cytomegalovirus reactivation remains a major cause morbidity and mortality following allogeneic hematopoietic stem cell transplantation. Monitoring cytomegalovirus-specific cellular immunity using standardized assay might improve the risk stratification patients. A prospective multicenter study was conducted in 175 intermediate- high-risk transplant recipients under preemptive antiviral therapy. Cytomegalovirus-specific measured IFN-γ ELISpot (T-Track® CMV). Primary aim to...
Highlights•A multifactorial influence determines the level and kinetics of torque teno (TT) viral load.•Numerous new influencing factors were identified.•Significant differences only visible after day 50 allogeneic hematopoietic stem cell transplantation.•Clinically relevant events showed no significant impact on TT load.•An early prognostic statement regarding further clinical outcome is limited.ABSTRACTTorque virus (TTV) a nonenveloped, single-stranded, circular DNA family Anelloviridae....
In immunocompromised patients a colonisation with fungi carries the risk to develop serious invasive fungal infection. An early detection is therefore important, but not optimal hitherto. Fortunately, molecular genetic methods have increased sensitivity of and limited time, until results are available. However, their success depends on an efficient extraction genomic DNA from cell in given diagnostic specimen. To improve routine preparation method for yeasts moulds, impact bead beating...
We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant manifestation and risk insufficiency.
Nd:YAG laser-induced thermo therapy (LITT) of rat brains is associated with blood-brain barrier (BBB) permeability changes. We address the question whether LITT-induced locoregional disruption BBB could possibly allow a passage chemotherapeutic agents into brain tissue to treat malignant glioma.CD Fischer rats were subject LITT left forebrain. Disruption was analyzed using Evans blue and immunohistochemistry (IH). Animals perfused paclitaxel, high-pressure liquid chromatography (HPLC)...
Serious clinical complications (SCC; CTCAE grade ≥ 3) occur frequently in patients treated for hematological malignancies. Early diagnosis and treatment of SCC are essential to improve outcomes. Here we report a deep learning model-derived SCC-Score detect predict from time-series data recorded continuously by medical wearable. In this single-arm, single-center, observational cohort study, vital signs physical activity were with wearable 31,234 h 79 (54 Inpatient Cohort (IC)/25 Outpatient...