A5063004210- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Genomics and Phylogenetic Studies
- Complement system in diseases
- Bacterial biofilms and quorum sensing
- Cardiac Imaging and Diagnostics
- Plant Stress Responses and Tolerance
- Enterobacteriaceae and Cronobacter Research
- Cardiovascular Disease and Adiposity
- Antibiotic Use and Resistance
- HIV Research and Treatment
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Vaccine Coverage and Hesitancy
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Blood groups and transfusion
- Dialysis and Renal Disease Management
- Natural product bioactivities and synthesis
- Artificial Intelligence in Healthcare
- MicroRNA in disease regulation
International Hellenic University
2024-2025
Aristotle University of Thessaloniki
2015-2024
Forthnet (Greece)
2017-2022
There is an unmet need of models for early prediction morbidity and mortality Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes ICU hospitalization death, b) develop artificial neural network (ANN) predicting these c) validate whether are impaired complement phenotype. prospectively recruited consecutive adult patients Caucasian origin, hospitalized due COVID-19. Through targeted next-generation sequencing, we...
Carnosic acid (CA) is a phenolic diterpene with anti-tumour, anti-diabetic, antibacterial and neuroprotective properties that produced by number of species from several genera the Lamiaceae family, including Salvia fruticosa (Cretan sage) Rosmarinus officinalis (Rosemary). To elucidate CA biosynthesis, glandular trichome transcriptome data S. were mined for terpene synthase genes. Two putative genes, namely SfCPS SfKSL, showing similarities to copalyl diphosphate kaurene synthase-like...
Our study aims to develop a data-driven framework utilizing heterogenous electronic medical and clinical records advanced Machine Learning (ML) approaches for: ( i ) the identification of critical risk factors affecting complexity Coronary Artery Disease (CAD), as assessed via SYNTAX score; ii development ML prediction models for accurate estimation expected score. We propose two-part modeling technique separating process into two distinct phases: (a) binary classification task predicting,...
MicroRNAs (miRNAs) create systems networks and gene-expression circuits through molecular signaling cell interactions that contribute to health imbalance the emergence of cardiovascular disorders (CVDs). Because clinical phenotypes CVD patients present a diversity in their pathophysiology heterogeneity at level, it is essential establish genomic signatures delineate multifactorial correlations, unveil variability seen therapeutic intervention outcomes. The clinically validated miRNA...
Abstract The spread of NDM-1-harboring Klebsiella pneumoniae is a worldwide concern. In this study the whole-genome sequence (WGS) carbapenem- and colistin-resistant K. 838Gr strain presented. This was isolated from urine sample patient in Intensive Care Unit (ICU) at Volos Hospital, Greece. initial assembly produced 224 contigs with combined genome size 5,561,803 bp GC content 57.21%. carried IncR, IncFIA, IncC, repB (R1701) replicons. Multilocus typing (MLST) analysis revealed that isolate...
Abstract The emergence of carbapenemase-producing Klebsiella pneumoniae poses a significant global health threat, particularly in hospital settings. This study reports on the first detection pandrug-resistant (PDR) high-risk ST15 K . strain co-producing NDM-1 and VIM-1 Greece. isolate was recovered from blood culture male patient admitted to Intensive Care Unit (ICU) Volos Hospital July 2024. Next generation Sequencing (NGS) confirmed presence bla genes. Other beta-lactamase type (CTX-M-15)...
Objectives Αn HIV-1 outbreak was identified among people who inject drugs (PWID) in Thessaloniki, Greece, during 2019–2021. We aimed to investigate the characteristics of this by means molecular epidemiology. Methods analysed 57 sequences from PWID sampled Thessaloniki 2019–2023. Phylogenetic trees were inferred using all subtype A since 1999 Greece and reference (n=4824). Phylodynamic analysis performed Bayesian birth-death skyline serial model. Results Most study belonged sub-subtypes A6...
Abstract Introduction Recurrent pregnancy loss (RPL) is a multifactorial disorder. The aim of this study was the detection various genetic polymorphisms and their correlation to RPL, in Greek women. Methods impact 12 thrombophilic evaluated, among 48 women with history vs 27 healthy parous Multiplex PCR situ hybridization on nitrocellulose films were performed, investigate previously reported as risk factors for RPL. Results Heterozygous FV Leiden, homozygous PAI‐1 4G/4G, heterozygous MTHFR...
Abstract Exosome selectivity mechanisms underlying exosome–target cell interactions and the specific traits affecting their capability to communicate still remain unclear. Moreover, capacity of exosomes efficiently deliver molecular cargos intracellularly needs precise investigation towards establishing functional exosome‐based delivery platforms exploitable in clinical practice. The current study focuses on: (a) exosome production from normal MRC‐5 Vero cells growing culture, (b)...
Abstract Background Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, important role of RANKL/OPG/RANK signaling axis physiology is well established. The aim this study was evaluate levels receptor activator nuclear factor kappa-B ligand (RANKL), (RANK) plasma osteoprotegerin (OPG) levels, T1D youngsters investigate factors that could influence OPG / RANK RANKL such as 25-hydroxy vitamin D [25(OH) D],...
To compare serum humanin concentrations in pregnant women with and without pre-eclampsia (PE).A case-control study where (PE group, n = 37; control 34) studied through history parameters (gynecological, obstetrical, personal, family), physical sonographic examination [body mass index (BMI), blood pressure obstetrical ultrasound], biochemical/hormonal assays [creatinine, urea, glutamic oxaloacetic transaminase (SGOT), pyruvic (SGPT), uric acid, platelets, urinary protein, humanin].There was...
Abstract Background To assess the level of knowledge and trust in policy decisions taken regarding coronavirus disease (COVID-19) pandemic among Epirus Health Study (EHS) participants. Methods The EHS is an ongoing deeply-phenotyped prospective cohort study that has recruited 667 participants northwest Greece until August 31st, 2020. Level on (SARS-CoV-2) transmission COVID-19 severity was labeled as poor, moderate or good. Variables assessing beliefs towards were summarized overall by sex,...