A5062423478- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Extracellular vesicles in disease
- Natural Compound Pharmacology Studies
- Epigenetics and DNA Methylation
Aristotle University of Thessaloniki
2018-2020
Abstract Exosome selectivity mechanisms underlying exosome–target cell interactions and the specific traits affecting their capability to communicate still remain unclear. Moreover, capacity of exosomes efficiently deliver molecular cargos intracellularly needs precise investigation towards establishing functional exosome‐based delivery platforms exploitable in clinical practice. The current study focuses on: (a) exosome production from normal MRC‐5 Vero cells growing culture, (b)...
Tumor heterogeneity presents a hindering factor that leads to therapeutic failures and limits the improvement of clinical outcomes within concept precision medicine. This heterogenous characteristic provides epithelial mesenchymal plasticity is considered an advantage for cancer cell metabolism genome function be adjusted microenvironment, also plays role in development drug resistance metastasis. To this respect, identifying druggable molecular targets modulate signaling networks, which...