A5002887483- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Iron Metabolism and Disorders
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Pharmacological Effects and Toxicity Studies
- Cell Adhesion Molecules Research
- Prenatal Screening and Diagnostics
- Histiocytic Disorders and Treatments
- Adolescent and Pediatric Healthcare
- Polyomavirus and related diseases
- Renal and related cancers
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
National Taiwan University Hospital
2016-2025
ShanghaiTech University
2025
Zhengzhou University
2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
National Taiwan University
2011-2024
Liaoning Technical University
2023
Yangzhou University
2023
Southwest University
2021-2022
Xidian University
2021
Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce the transfusion burden (the total number of units transfused) in such patients.
To meet the twin carbon goals of “carbon peak” and neutrality”, it is crucial to make scientific predictions about emissions in transportation sector. The following eight factors were chosen as effect indicators: population size, GDP per capita, civil vehicle ownership, passenger freight turnover, urbanization rate, industry structure, emission intensity. Based on pertinent data from 2002 2020, a support vector machine model, improved by genetic algorithm (GA-SVM), was created predict peak...
Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by <sup>18</sup>F-fluorodihydroxyphenylalanine (<sup>18</sup>F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy clinical role of <sup>18</sup>F-FDOPA PET in neuroblastic <b>Methods:</b> From 2008 to 2011, patients with tissue-proven receiving at initial diagnosis or during follow-ups were enrolled. The...
Despite current risk‐directed therapy, approximately 15–20% of pediatric patients with acute lymphoblastic leukemia (ALL) have relapses. Recent genome‐wide analyses identified that an alteration IKZF1 is associated very poor outcomes in B‐cell progenitor ALL. In this study, we determined the prognostic significance deletions childhood This study analyzed 242 ALL Taiwan. We developed a simple yet sensitive multiplex quantitative PCR coupled capillary electrophoresis to accurately determine...
OBJECTIVE—To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients. RESEARCH DESIGN AND METHODS—A total 89 patients were interviewed. Diabetes was previously diagnosed 14 them. In remaining 75 patients, 68 participated an oral test. Potential identified using independent t test, χ2 Fisher’s exact Logistic regression analysis used to select that best predicted tolerance. A two-tailed P value &lt;0.05 considered be...
This study determined the prognostic value of volumetric parameters derived from pretreatment F-FDG and F-DOPA PET/CT neuroblastoma their correlation with clinical histopathologic features.A total 25 children underwent within 4 weeks. The SUVmax primary tumors on PET were recorded as SUVFDG SUVDOPA, respectively. For tumors, 40% was used to generate volume interest. If below 2.5, an SUV threshold 2.5 instead. Metabolic tumor (MTV), lesion glycolysis (TLG), dopaminergic (DTV), activity (TLDA)...
Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive stem cells. We aimed to elucidate the relationships between histological distribution of β-catenin and cell markers with clinical outcomes hepatoblastoma.Immunohistochemistry was applied detect expression 31 hepatoblastoma tumors. analyzed relationship course hepatoblastoma.Thirty-one patients were diagnosed at mean age 2.58 ± 3.78 years, 7 (22.58%) died. A lack anticipated decrease...
A study of newborn screening for severe combined immunodeficiency (SCID) by detecting the T-cell receptor excision circle (TRECs) copy number in dried blood spots (DBSs) collected from newborns 3 days age began 2010 Taiwan, and SCID was subsequently implemented country-wide 2012. total 920,398 were screened during a period 78 months. Of these, 175 (0.02%) requested to undergo an immune function survey, 136 cases (1 6768 newborns) ultimately diagnosed as having T cell lymphopenia. The...
Scope The development of atopic dermatitis (AD) in infants is closely related to the lagging intestinal microbiota, including that inoculated by breast milk bacteria, and immune development. Lactobacillus reuteri Fn041 a secretory immunoglobulin A (sIgA) ‐coated bacterium derived from human milk. Methods Results We intervene with L. maternal offspring BALB/C mice during late gestation lactation after weaning pups, respectively. AD then induced MC903. significantly suppresses symptoms such as...
The incidence and clinical spectrum of severe bacterial infection were studied in 89 patients with thalassemia major that was diagnosed between January 1971 March 2002. There 20 24 episodes infection, resulting an 1.6 infections per 100 patient-years. included liver abscess (6 cases), septicemia soft-tissue (2 osteomyelitis corneal ulcer (1 case), enteritis abscesses the lung, kidney, intra-abdominal region, retropharynx, gums, buttocks case each). leading causal microorganisms gram-negative...
Abstract Background Diabetes mellitus is a major endocrinopathy for patients with thalassemia major. Although diabetes multifactorial, iron loading its primary cause and management poses clinical challenge. Detecting the pre‐diabetes stage critical because can potentially be reversed or prevented. Procedure Patients who received regular blood transfusion therapy from 1994 to 2010 were evaluated incidence of glucose dysregulation. The association between patients' clinical, biochemical, image...
Abstract Purpose: Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in childhood. β-1,4-Galactosyltransferase III (B4GALT3) highly expressed human fetal brain and responsible for the generation of poly-N-acetyllactosamine, which plays critical role progression. We therefore investigated expression B4GALT3 NB. Experimental Design: examined specimens from 101 NB patients by immunohistochemistry analyzed correlation between clinicopathologic factors or survival. The...
Cytomegalovirus (CMV) is a major pathogen causing significant mortality and morbidity in immunocompromised hosts. It important to find risk factors associated with CMV viremia its outcome.We investigated the incidence, time of onset, for viremia, characteristics diseases 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). Between August 2011 March 2014, cases HSCT at National Taiwan University Children's Hospital were reviewed. Viremia was identified by plasma...
// Wan-Ling Ho 1,4,6,7,* , Chih-Hsing Chou 5,* Yung-Ming Jeng 2 Meng-Yao Lu 1 Yung-Li Yang Shiann-Tarng Jou Dong-Tsamn Lin Hsiu-Hao Chang Kai-Hsin Wen-Ming Hsu 3,8 and Min-Chuan Huang 5,8 Department of Pediatrics, National Taiwan University Hospital College Medicine, Taipei, Pathology, 3 Surgery, 4 Graduate Institute Clinical 5 Anatomy Cell Biology, 6 Shin Kong Wu Ho-Su Memorial Hospital, 7 School Fu Jen Catholic University, New Taipei City, 8 Research Center for Developmental Biology...
A unique cluster of childhood leukemia has recently occurred around the city Fallon in Churchill County, Nevada. From 1999 to 2001, 11 cases were diagnosed this county 23,982 people. Exposures related a nearby naval air station such as jet fuel or an infectious agent carried by aviators have been hypothesized potential causes. The possibility that could be attributed chance was also considered. We used data from Surveillance, Epidemiology, and End Results Program (SEER) examine likelihood...