A5065005582- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Bone and Joint Diseases
- Peroxisome Proliferator-Activated Receptors
- Folate and B Vitamins Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Acute Ischemic Stroke Management
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Immunodeficiency and Autoimmune Disorders
- Blood properties and coagulation
- Trace Elements in Health
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Cancer, Lipids, and Metabolism
University of Nigeria
2010-2024
University of Nigeria Teaching Hospital
2011-2023
University of Florida
2020
Guy's and St Thomas' NHS Foundation Trust
2006-2008
Weatherford College
2008
St Thomas' Hospital
1999-2007
University of London
2005-2007
Stepping Hill Hospital
2007
Guy's Hospital
2006
Lambeth Hospital
2003-2005
Summary Deferasirox is a once‐daily, oral iron chelator developed for treating transfusional overload. Preclinical studies indicated that the kidney was potential target organ of toxicity. As patients with sickle cell disease often have abnormal baseline renal function, primary objective this randomised, open‐label, phase II trial to evaluate safety and tolerability deferasirox in comparison deferoxamine population. Assessment efficacy, as measured by change liver concentration (LIC) using...
Summary Serum bilirubin levels and predisposition to gallstones in sickle cell disease (SCD) are influenced by genetic variation the hepatic uridine diphosphate (UDP)‐glucuronosyltransferase ( UGT1A1 ) gene, but association is not consistent. This study investigated whether gene encoding haem oxygenase HMOX1 ), a rate‐limiting enzyme upstream of UGT1A catabolic pathway, α ‐thalassaemia could explain some inconsistent effects. The [TA] n [GT] promoter polymorphisms globin genotypes were...
Abstract: Background : The severity of sickle cell disease (SCD) increases with leukocyte count. biological basis could be that adherence to vascular endothelium mediated by adhesion molecules (AMs) facilitates vaso‐occlusion, the basic pathological process in SCD. Objective To find out if there is a relationship between expression AMs leukocytes and clinical manifestations Methods Flow cytometry was used study AM 100 patients homozygous (HbSS) 34 genotype HbAA controls. effect hydroxyurea...
Abstract. Serum concentrations of seven acute‐phase reactants: albumin, transferrin (Tf), alpha‐1‐antitrypsin (AIAT), caeruloplasmin (Cp), α 2‐macroglobulin ( 2‐MG), haptoglobin (hp) and C‐reactive protein (CRP) were determined in 73 subjects with varying severities homozygous sickle cell (HbSS) disease. Fifty healthy comparable sex, age socio‐economic class distributions as the HbSS served controls. Albumin 2‐MG all subject groups. Tf hp levels significantly reduced groups relative to...
Priapism is a common complication of sickle cell disease (SCD) that could lead to erectile dysfunction and psychosocial problems. Treatment established fulminant priapism usually not satisfactory. It therefore important prevent this SCD. The alpha-adrenergic agonist etilefrine (50-100 mg/d) produced good clinical response in 13 18 (72%) adults who have recurrent priapism; 17 had SCD one trait. After follow-up 1-48 months, none the people on developed hypertension or sexual dysfunction....
Hyperhaemolysis syndrome (HS), a in which there is destruction of both donor and recipient red cells after transfusion, well recognised patients with sickle cell disease beta-thalassaemia. It has also been reported patient myelofibrosis. In acute forms HS, evidence antibody-mediated haemolysis lacking, it proposed that the transfused patient's own blood were destroyed by hyperactive macrophages. Continuation transfusion may be lethal as this can further exacerbate haemolysis. We report two...
Okpala I, Ibegbulam O, Duru A, Ocheni S, Emodi Ikefuna Umar G, Asinobi Madu Okoye Nwagha T, Oguonu U, Uamai Agwu Nonyelu C, Anike Agu K, Anigbo Chukwura Ugwu Herrada S. Pilot study of omega-3 fatty acid supplements in sickle cell disease. APMIS 2011; 119: 442–8. In a previous retrospective study, it was observed that the greater amounts acids eicosapentaenoic (EPA) and docosahexaenoic (DHA) blood, lesser number complications disease (SCD) higher steady state haemoglobin level. SCD causes...
Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion, and ischemia. HIV-1 infection was previously shown to be suppressed in SCD PBMCs. Here, we report that suppression attributed the increased expression of iron, hypoxia, interferon-induced innate antiviral factors. Inhibition upregulated genes,
Background: Stroke is a life-changing, debilitating complication of sickle cell disease (SCD). Previous studies had recorded high stroke prevalence amongst this group patients. Nigeria has large population people affected by condition and study aims to assess the in population.Methodology: data from 14 physicians working 11 tertiary health centres across country was collated doctors using registers patient case notes. This then used obtain overall adult children.Results: The patients...
Objective To obtain multicentre data on the prevalence of normal, high or conditional (intermediate) blood velocity in cerebral arteries among children with sickle cell disease (SCD) Nigeria. Design A prospective observational study five tertiary healthcare institutions. By transcranial Doppler (TCD) ultrasonography, artery peak systolic (PSV) was determined 193 SCD and time averaged mean maximum (TAMMV) a different cohort 115 children. This design to make findings relevant hospitals TCD...
The aim of this study was to find out if the number crises and complications sickle cell anaemia (SCA) relate complement function, or levels circulating immune complexes (CIC), factor B (Bf), C3 C4. In 73 steady-state HbSS patients 50 HbAA control subjects, we determined haemolytic activity alternative pathway (AP50), classical (CH50); serum concentrations Bf, C3, C4 CIC. By clinical examination each patient review medical records, SCA which had occurred mean per year over a minimum period 3...
The severity of Sickle Cell Anaemia (SCA) in terms frequency painful Vaso-Occlusive Crises (VOC) may be affected by clinical and haematological parameters amongst others. Elucidation these factors a given disease prevalent environment is necessary for prompt effective management patients with frequent VOC.This study aimed at determining the laboratory predictors VOC among SCA Enugu, Southeastern Nigeria.It was cross-sectional 100 consecutive receiving care University Nigeria Teaching...