A5100667330- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Acute Myeloid Leukemia Research
- Aquaculture Nutrition and Growth
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Aquaculture disease management and microbiota
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
- Aquatic life and conservation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Protein Hydrolysis and Bioactive Peptides
- Reproductive biology and impacts on aquatic species
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Lysosomal Storage Disorders Research
- Lung Cancer Research Studies
- Infectious Diseases and Mycology
- Frailty in Older Adults
- Phytase and its Applications
- Hematological disorders and diagnostics
- NF-κB Signaling Pathways
Ocean University of China
2010-2025
Institute of Hematology & Blood Diseases Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Anhui Provincial Children's Hospital
2024
Chengdu Center for Disease Control and Prevention
2024
Jilin Agricultural University
2024
Hebei General Hospital
2024
National Clinical Research Center for Digestive Diseases
2022-2023
State Key Laboratory of Oral Diseases
2023
Guiyang Medical University
2023
We examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/Aβ42 reference standards.
Four less well-studied but promising "emerging" cerebrospinal fluid (CSF) biomarkers are elevated in late-onset Alzheimer disease (AD): neurogranin, synaptosomal-associated protein-25 (SNAP-25), visinin-like protein 1 (VILIP-1), and chitinase-3-like (YKL-40).CSF SNAP-25, VILIP-1, YKL-40 were measured families carrying autosomal-dominant AD mutations.The four emerging CSF significantly the mutation carriers (n = 235) versus noncarriers 145). altered very early time course, approximately 15-19...
Candidemia is the most common, serious fungal infection and Candida antifungal resistance a challenge. We report recent surveillance of candidemia in China.The study encompassed 77 Chinese hospitals over 3 years. Identification species was by mass spectrometry DNA sequencing. Antifungal susceptibility determined using Clinical Laboratory Standards Institute broth microdilution method.In total, 4010 isolates were collected from patients. Although C. albicans common species, non-albicans...
This study was conducted to compare the effects of fish meal (FM) replacement by two types soybean meals (SBMs) on activities digestive enzyme, intestinal brush border enzyme and aminotransferases juvenile Japanese seabass (initial weight 8.3 ± 0.2 g). Nine isonitrogenous (crude protein 44%) isoenergetic (20 kJ g−1) experimental diets replacing 0 (the control), 15%, 30%, 45% 60% FM high-protein SBM (HSB) or commercial (CSB) were formulated. The concentrations anti-nutritional factors (ANFs)...
Due to unique metal-support interactions, loaded structures have been widely used in the structural design of hydrogen-extraction reaction (HER) electrocatalysts. However, development catalysts that are both active and stable remains a great challenge. Herein, we successfully anchored Pt nanoparticles on ultrathin nanobelts construct crystalline/amorphous NPs/CNWOx NBs heterostructure, which possesses dual advantages fast electron transfer crystalline materials effective exposure sites...
Acute myeloid leukemia (AML) is a heterogeneous cancer, making outcomes prediction challenging. Several predictive and prognostic models are used but have considerable inaccuracy at individual level. We tried to increase accuracy using multi-omics strategy. interrogated data from 1391 consecutive, newly diagnosed subjects with AML, integrating information on mutation topography, DNA methylation, transcriptomics. developed an unsupervised classification system (UAMOCS) these data. UAMOCS...
Introduction With the introduction of strategy a strong marine power and “dual-carbon” goal, green, low-carbon sustainable development has become an important requirement for growth Ocean Economy. Green finance is financial activity that promotes environmental improvement, climate change response efficient resource utilization. The goal major national proposed by Chinese Government in 2020 to achieve carbon peaking neutrality, which two-stage emission reduction strategic Government. China...
Acute myeloid leukemia (AML) is characterized by the accumulation of cytogenetic and molecular abnormalities. Isocitrate dehydrogenase 1 2 ( IDH1/2 ) mutations occur in 11% to 20% adults with AML. The outcome -mutated AML heterogeneous affected co-mutational patterns. We retrospectively analyzed 118 patients who were retrieved from 1597 newly diagnosed treated intensive chemotherapy. Univariate analysis revealed NPM1 mutation was a favorable factor p = 0.019) for overall survival (OS),...
The high fatality of patients with blast phase (BP) chronic myeloid leukemia (CML) necessitates identification high-risk (HR) to prevent onset BP. Here, we investigated the risk BP based on additional chromosomal abnormality (ACA) profiles in a cohort 2326 CML treated tyrosine kinase inhibitors (TKIs). We examined time intervals from initial diagnosis ACA emergence (interval 1), 2), and survival after 3). Based associated each ACA, were stratified into intermediate-1, intermediate-2, HR...
Abstract Background Prickle planar cell polarity protein 1 (PRICKLE1), a core component of the non-canonical Wnt/planar (PCP) pathway, was recently reported to be upregulated and correlated with poor prognosis in solid cancers. However, effect PRICKLE1 on acute myeloid leukemia (AML) remains unknown. This study aims characterize prognostic significance expression patients AML. Methods RNA-seq performed compare mRNA profiles AML healthy controls. qRT-PCR western blotting were used analyze...
There is an urgent need for cost-effective, easy-to-measure biomarkers to identify subjects who will develop Alzheimer's disease (AD), especially at the pre-symptomatic stage. This stage can be determined in autosomal dominant AD (ADAD) which offers opportunity observe dynamic biomarker changes during life-course of stages. study aimed investigate serum different stages and potential novel protein presymptomatic AD. In first stage, 32 individuals [20 mutation carriers including 10 with AD,...
Abstract Introduction As the role of biomarkers is increasing in Alzheimer's disease (AD) clinical trials, it critical to use a comprehensive temporal biomarker profile that reflects both baseline and longitudinal assessments establish more precise association between change cognition. Because age onset dementia symptoms highly predictable, there are relatively few age‐related comorbidities, Dominantly Inherited Alzheimer Network autosomal dominant AD population affords unique opportunity...
Abstract Introduction While the Dominantly Inherited Alzheimer Network Trials Unit (DIAN‐TU) was ongoing, external data suggested higher doses were needed to achieve targeted effects; therefore, of gantenerumab increased 5‐fold, and solanezumab 4‐fold. We evaluated what extent mid‐trial dose increases produced a dose‐dependent treatment effect. Methods Using generalized linear mixed effects (LME) models, we estimated annual low‐ high‐dose in clinical, cognitive, biomarker outcomes. Results...
In acute myeloid leukemia (AML), further investigation is warranted to integrate measurable residual disease (MRD) with genetic characteristics for formulating a dynamic prognostic system predicting response and selecting appropriate postremission therapeutic strategies.
Key Clinical Message This report describes a case of diffuse large B‐cell lymphoma with MYD88 L265P and KM2DT mutation decompensated alcohol‐related liver cirrhosis. And the treatment is successful in this patient, who had multiple complications poor prognostic factors. Abstract The showed complete response no after four courses combination chemotherapy. Lymphoma one most common malignant tumors, but cases DLBCL cirrhosis are much rarer especially we reviewed relevant mechanisms. Although...
Summary The prognostic factors to stratify acute myeloid leukaemia (AML) with double‐mutated CCAAT/enhancer‐binding protein alpha ( CEBPA dm) into different risk groups remains be determined. In this retrospective study, we evaluated 171 consecutive patients newly diagnosed AML dm by a Cox proportional hazards regression model. univariate analyses, colony stimulating factor 3 receptor CSF3R ) and Wilms tumour 1 WT1 mutations were associated poor relapse‐free survival (RFS). induction...
To partially or entirely replace the use of live foods for mandarin fish (Siniperca chuatsi ♀× Siniperca scherzeri♂) with frozen artificial feeds, a detailed understanding their digestive physiology and influence these replacements is needed. The experiment was conducted in recirculation system 10 weeks. At termination feeding trial, protease activity alimentary tract aspartate aminotransferase (AST) livers fed feed were significantly higher than those feeds. Fish had highest AST alanine...
Dietary histidine requirements for large yellow croaker (initial average weight, 6.0 ± 0.10 g) were quantified by feeding isonitrogenous (crude protein 44%) and isocaloric (20 KJ/g) amino acid test diets with graded levels of [0.45% (D1), 0.66% (D2), 0.78% (D3), 0.98% (D4), 1.24% (D5) 1.40% (D6) dry diet]. Each diet was randomly assigned to triplicate floating sea cages (1.0 × 1.0 1.5 m), 60 fish/cage. At the end 51 day experiment, final weight (FW) gain (WG) showed a positive correlation...